The final checkpoint. Cancer as an adaptive evolutionary mechanism

Petkova, Rumena; Chakarov, Stoyan

doi:10.1080/13102818.2016.1152163

Cited by 7 publications

(10 citation statements)

References 51 publications

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“…However, when said proto-oncogenes undergo alterations, they become oncogenes, and among other things, they "trigger" cell multiplication in an uncontrolled manner. 19 Fortunately, as there are proto-oncogenes, there are others that control, regulate, and even oppose their activity. They are known as suppressor genes or anti-oncogenes.…”

Section: Development Evolved By and Against Cancermentioning

confidence: 99%

The ecological and evolutionary meaning of cancer

Creek¹,

Sánchez²,

Esteris³

2018

MOJAP

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Cancer is a serious health problem worldwide. The introduction of an ecological and evolutionary perspective of malignant neoplasms is aimed at a more systemic and objective approach to the nature of this heterogeneous group of diseases. With the aim of an approach to the most generalized ideas existing at present on the ecologicalevolutionary perspective of cancer, the present systematic review was carried out. Cancer is a universal phenomenon that affects all forms of multicellular organisms. The risk of developing malignant tumors is closely related to the patterns of life histories traced by the evolutionary process according to the adaptive need of organisms to the different ecological niches they occupy. There is an association between the evolutionary development of protective mechanisms against malignant tumors and the evolutionary cost of these in terms of reproductive success. Reproductive success seems to depend on body size, the distribution of energy towards basic processes and the basal risk of cancer. Natural selection favors effective mechanisms that protect against cancer as long as they allow an optimization of other traits that determine adaptive success. The conclusions derived from these ecological and evolutionary principles should serve to better characterize the factors that depend both on the biological and environmental factors that influence the risk of carcinogenesis. More than 90% of the increase in basal risk of cancer, even in natural species, is due to human activity, and therefore, can be modified.

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Section: Development Evolved By and Against Cancermentioning

confidence: 99%

The ecological and evolutionary meaning of cancer

Creek¹,

Sánchez²,

Esteris³

2018

MOJAP

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“…Physiologically, DNA quality is checked and verified by a complex set of rules and restrictions during cell division. 1 The control mechanism in the body can malfunction, forming cancer cells. 2 Cancer constitutes a large number of diseases that are characterized by abnormal cell development, which divide uncontrollably and can infiltrate and destroy normal body tissues.…”

Section: Introductionmentioning

confidence: 99%

A high glucose concentration is well tolerated by colorectal adenocarcinoma and melanoma cells but toxic to normal human gingival fibroblast: Results of an in vitro investigation

2020

Makara J Health Res

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“…This, nevertheless, is valid only within certain limits, as it is presently believed that there are natural mechanisms that prevent both 'ultimate resistance to mutation' and 'ultimate propensity for mutation' in order to keep the evolution going [44,45].…”

Section: Individual Capacity For Dna Repairmentioning

confidence: 99%

Some problems and errors in cytogenetic biodosimetry

Mosse

Kilchevsky

Nikolova

et al. 2016

Biotechnology & Biotechnological Equipment

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Human radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2-3 standard deviations). Thus, the same dose of radiation may result in different levels of genotoxic damage (commonly measured as chromosome aberration rates) in different individuals. There is significant genetic component in individual radiosensitivity. It is related to carriership of variant alleles of various single-nucleotide polymorphisms (most of these in genes coding for proteins functioning in DNA damage identification and repair); carriership of a different number of alleles producing cumulative effects; amplification of gene copies coding for proteins responsible for radioresistance, mobile genetic elements and others. Among the other factors influencing individual radioresistance are: the radioadaptive response; the bystander effect; the levels of endogenous substances with radioprotective and antimutagenic properties and environmental factors such as lifestyle and diet, physical activity, psychoemotional state, hormonal state, certain drugs, infections and others. These factors may have radioprotective or sensibilizing effects. Apparently, there are too many factors that may significantly modulate the biological effects of ionizing radiation. Thus, conventional methodologies for biodosimetry (specifically, cytogenetic methods) may produce significant errors if personal traits that may affect radioresistance are not accounted for.

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The final checkpoint. Cancer as an adaptive evolutionary mechanism

Cited by 7 publications

References 51 publications

The ecological and evolutionary meaning of cancer

The ecological and evolutionary meaning of cancer

A high glucose concentration is well tolerated by colorectal adenocarcinoma and melanoma cells but toxic to normal human gingival fibroblast: Results of an in vitro investigation

Some problems and errors in cytogenetic biodosimetry

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