The fifth myron karon memorial lecture; The cure of cancer by chemotherapy ‐ reflections on how it happened

Cg, Zubrod

doi:10.1002/mpo.2950080202

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…The effect of cytotoxic chemotherapy on intestinal absorption has been infrequently studied, despite the common use of drugs in combinations (Zubrod, 1980) and a low therapeutic ratio, which make any interaction potentially serious (Prescott, 1980). Methotrexate is one of the few cytotoxic drugs studied.…”

Section: Discussionmentioning

confidence: 99%

The effect of food and concurrent chemotherapy on the bioavailability of oral etoposide

Harvey¹,

Slevin²,

Joel³

et al. 1985

Br J Cancer

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Summary There is no information on the effect of food or concurrent drug administration on the bioavailability of oral etoposide, despite the fact that treatment is frequently administered over several days and most often in combination with other cytotoxic agents. The influence of these factors has been studied in 11 Etoposide was introduced into clinical trials in the early 1970s (Issell, 1982) and is established in the treatment of several malignancies, including small cell lung cancer, germ cell tumours and lymphomas (Arnold, 1979; Issell & Crooke, 1979;Vogelzang et al., 1982).The demonstration of schedule dependency in both experimental systems (Dombernowsky & Nissen, 1973;Rozencweig et al., 1977;D'Incalci & Garattini, 1982) and possibly also in man (Cavalli et al., 1978;Pedersen & Hansen, 1983) has led to most schedules of therapy being given over several (usually 3-5) days (Arnold, 1979;Nissen et al., 1980;Issell, 1982).The bioavailability of the oral etoposide capsule has been shown to be approximately 50% but with large variation between patients Harvey et al., 1984a). Despite the widespread use of oral etoposide over 3-5 days and its predominant use as part of combination chemotherapy regimens (Arnold, 1979;Comis, 1982;Rivera et al., 1982;Williams & Einhorn, 1982), there are no data concerning the influence of food or other chemotherapy on etoposide bioavailability.The intestinal absorption of some drugs has been shown to be affected by both food (Melander, 1978;McLean et al., 1978;Pinkerton et al., 1980) and chemotherapy (Pinkerton et al., 1982). The effect of food and concomitant oral and intravenous chemotherapy on the bioavailability of etoposide has therefore been studied. Materials and methods PatientsEleven patients receiving chemotherapy for extensive small cell lung carcinoma were studied. All were ambulant (performance score > 60% Karnofsky et al., 1948) with normal bone marrow, hepatic and renal function. No patients had disturbance of the gastrointestinal tract. Eight patients receiving primary chemotherapy were studied on 3 separate occasions to assess the effect of food and concomitant oral chemotherapy on etoposide bioavailability (Study 1). Six patients (3 of whom had previously been part of the above study) were receiving therapy for relapsed extensive SCLC and were studied on 3 successive days to assess the effect of intravenous and oral chemotherapy on etoposide bioavailability (Study 2).

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Section: Discussionmentioning

confidence: 99%

The effect of food and concurrent chemotherapy on the bioavailability of oral etoposide

Harvey¹,

Slevin²,

Joel³

et al. 1985

Br J Cancer

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“…By integrating laboratories within patient care areas opportunities for success were maximized 2. Thus, starting in 1955, the effects of novel chemotherapy agents such as methotrexate, supportive care measures including infection prophylaxis and platelet transfusions to prevent life‐threatening hemorrhages, and multi‐agent chemotherapy (vincristine and prednisone) and the psychological effects of cancer (including allowing older children enrolled in cancer research studies to be included in research‐related decisions) were investigated 23.…”

Section: From Madness To Methodsmentioning

confidence: 99%

The successful integration of research and care: How pediatric oncology became the subspecialty in which research defines the standard of care

Unguru

2011

Pediatric Blood & Cancer

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Pediatric oncology successfully embodies the integration of patient care with medical research. Several factors may explain this phenomenon. Specifically, the study of childhood leukemia provided scientists with principles by which they could approach other forms of cancer. Multicenter, cooperative group RCTs resulted in meaningful advances. Parents' often desperate hope for a cure, combined with clinician-investigators efforts to continually improve upon treatments resulted in important improvements in children's lives. Finally, the seemingly tolerant regulatory oversight of human subjects research in the early years of childhood cancer research paradoxically helped link research with care, thus solidifying this bond for years to come.

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Comparative nephrotoxicity of carboplatin and cisplatin in combination with tobramycin

Bregman

Williams

1986

Cancer Chemother. Pharmacol.

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The nephrotoxic potentials of cisplatin and carboplatin, alone and in combination with the aminoglycoside antibiotic tobramycin, were compared in male rats. Sixty (60) male Sprague-Dawley rats were divided into six groups of ten rats each and received the following treatments: Group I, saline; group II, cisplatin (5 mg/kg); group III, cisplatin (5 mg/kg) + tobramycin (50 mg/kg); group IV, carboplatin alone (50 mg/kg); group V, carboplatin (50 mg/kg) + tobramycin (50 mg/kg); and group VI, tobramycin alone (50 mg/kg). Carboplatin and cisplatin were each administered as a single i.v. injection on day 1. Tobramycin was administered i.-m. once daily on days 1-5. All rats were euthanatized on day 6. Smaller body weight gains occurred in groups II-V than in saline controls. Serum urea nitrogen (BUN) levels recorded on day 6 were elevated in group III. BUN values of all other groups were normal. Histopathologic examination of kidneys revealed acute tubular injury in rats treated with cisplatin, whether alone or in combination with tobramycin, and in carboplatin/tobramycin-treated rats. Carboplatin and tobramycin, when administered separately, were not nephrotoxic. The combination of cisplatin and tobramycin proved to be the most nephrotoxic treatment.

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The fifth myron karon memorial lecture; The cure of cancer by chemotherapy ‐ reflections on how it happened

Cited by 4 publications

References 8 publications

The effect of food and concurrent chemotherapy on the bioavailability of oral etoposide

The effect of food and concurrent chemotherapy on the bioavailability of oral etoposide

The successful integration of research and care: How pediatric oncology became the subspecialty in which research defines the standard of care

Comparative nephrotoxicity of carboplatin and cisplatin in combination with tobramycin

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