The Fibula in Congenital Pseudoarthrosis of the Tibia: The EPOS Multicenter Study

Congenital Pseudarthrosis of the Tibia: Combined Pharmacologic and Surgical Treatment Using Biphosphonate Intravenous Infusion and Bone Morphogenic Protein with Periosteal and Cancellous Autogenous Bone Grafting, Tibio-Fibular Cross Union, Intramedullary

“…The EPOS study [26,39] reported a healing rate of 61% (19 of 31 patients). Seven of the 19 healed patients required additional procedures, such as grafting, plating, or IM rodding.…”

Periosteal Grafting for Congenital Pseudarthrosis of the Tibia: A Preliminary Report

“…The natural history of CPT is recalcitrant nonunion, progressive LLD and deformity, and recurrent refracture even after initial union [4,5,20,25,28,31]. The primary objective of treatment for CPT is to obtain union.…”

Reconstructive surgery of the human tibia by use of external ring fixator and the Ilizarov method

“…Hence, the fact that all segments were intraoperatively axially aligned, did not prevent malaligment. Fibular pathology occurs in about 60% of CPT cases (Keret et al 2000). The fibula was hypotrophic or even aplastic in all our cases, but one, which may be the main reason for the appearance of recurrent deformity in the late follow-up cases.…”

“…Our study of 7 patients in Paper 5 includes a small number, but with exception of the CPT papers based on the multicenter study organized by the European Paediatric Orthopaedic Society (EPOS), only a few cases are also involved in other studies (Inan et al 2006, Ohnishi et al 2005. However, the EPOS study has resulted in several publications dealing with the CPT diagnosis , Keret et al 2000, including reports of the results in patients operated with the Ilizarov bone transport method .…”