The Fibroblast Growth Factor Family An Overview

Baird, Andrew; Klagsbrun, Michael

doi:10.1111/j.1749-6632.1991.tb49010.x

Cited by 103 publications

(79 citation statements)

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“…Acidic and basic FGF (aFGF and bFGF) are the prototype members of a heparin-binding family of growth factors which at present consists of nine distinct proteins (Miyamoto et al, 1993; suggested nomenclature FGF-1 to FGF-9, Baird and Klagsbrun, 1991). FGF has been shown to induce a wide range of responses in various cell and tissue types, including cell proliferation, differentiation, extracellular matrix deposition, and cell migration (Burgess and Maciag, 1989;Klagsbrun, 1989;Rifkin and Moscatelli, 1989;McAvoy and Chamberlain, 1990).…”

Section: Introductionmentioning

confidence: 99%

Spatio‐temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis

Iongh

McAvoy

1993

Developmental Dynamics

111

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As part of an investigation into the role FGF in lens development, we have studied the distribution of both aFGF and bFGF during eye morphogenesis from embryonic days 10 to 18 (E10–E18) in the rat. For aFGF, reactivity was found only in ectoderm at E10, prior to contact between the optic vesicle and presumptive lens ectoderm. During lens placode formation (E11) there was a transient, diffuse reactivity for aFGF in anterior optic vesicle cells directly apposed to the labelled ectoderm of the lens placode. At E12 the diffuse reactivity of the lens placode had changed to a discrete localisation along the basolateral surfaces of differentiating cells in the lens pit. Similar reactivity was associated with neuroblasts along the inner margin of the optic cup. At the early lens vesicle stage (E13) the baso‐lateral aFGF‐like reactivity associated with elongating lens cells was more intense and extensive. From the late lens vesicle stage (E14) to E18, reactivity in the lens was increasingly restricted to the equatorial regions which incorporate the germinative and transitional zones. From E16 to E18, aFGF‐like reactivity in the retina was predominantly localised in the peripheral regions corresponding to the developing ciliary body and iris and in the central retina associated with ganglion cell axons. For bFGF, weak reactivity was detectable as early as E13 in the developing lens capsule and increased in intensity during lens development with the posterior capsule reacting more intensely than the anterior capsule. Retinal bFGF‐like reactivity was first detected at E14, associated with differentiating ganglion cells in the central retina. From E16 to E18 the retinal ganglion cells showed increasing reactivity and the pattern of reactivity followed the centro‐peripheral pattern of retinal development. Thus reactivity for aFGF is first detected in presumptive lens ectoderm and subsequently in optic vesicle cells which are closely associated with lens ectoderm. This raises the possibility that aFGF may be involved in inductive interactions between presumptive lens ectoderm and optic vesicle. Furthermore the localisation patterns established for both aFGF and bFGF during lens and retina morphogenesis suggest an important role for FGF in regulating their morphogenesis and growth. © 1993 Wiley‐Liss, Inc.

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Section: Introductionmentioning

confidence: 99%

Spatio‐temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis

Iongh

McAvoy

1993

Developmental Dynamics

111

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“…The target cells of FGFs are also diverse and include cells derived from all germ layers. FGFs can act as mitogens, repressors of differentiation, or as angiogenic and neurotrophic factors, depending on the form of FGF applied and on the recipient cell type (Mason, 1994;Baird and Klagsbrun, 1991).…”

Section: Introductionmentioning

confidence: 99%

Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning

Szebenyi

Savage

Olwin

et al. 1995

Developmental Dynamics

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Members of the fibroblast growth factor (FGF) family of growth factors are key regulators of limb skeletal patterning and growth. Abnormal expression of FGFs or mutations in their receptors (fgfrs) result in skeletal disorders. Here we show that changes in the expression of f&s are intrinsic properties of differentiating cartilage. In mesenchymal micromass cultures differentiating into cartilage, as in ovo, fgfr 1 mRNA was found predominantly in undifferentiated, proliferating mesenchyme, f& 2 in precartilage cell aggregates, and fgfi-3 in differentiating cartilage nodules. Thus, our data suggest that switches in the expression of fgfr 1, 2, and 3 mRNAs are associated with phases of cartilage patterning both in vitro and in ovo, and mark distinct stages in the development of the limb skeleton. o 1995 Wiley-Lisa, Inc.

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“…Fibroblast growth factors (FGFs) comprise a family of nine related polypeptides with broad mitogenic and cell survival activities (1)(2)(3). FGF-1 (acidic FGF) and FGF-2 (basic FGF), the first family members to be identified, purified, and sequenced, are widely expressed and are potent mitogens for a variety of cell types (4,5).…”

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Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

Smallwood

Muñoz-Sanjuán

Tong

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

363

306

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Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30%o identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 (basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.Fibroblast growth factors (FGFs) comprise a family of nine related polypeptides with broad mitogenic and cell survival activities (1-3). FGF-1 (acidic FGF) and FGF-2 (basic FGF), the first family members to be identified, purified, and sequenced, are widely expressed and are potent mitogens for a variety of cell types (4, 5). The gene encoding FGF-3 is a common target for activation by the mouse mammary tumor virus (6), and the genes encoding FGF-4, have transforming activity when introduced into NIH 3T3 cells (7-9). FGF-7, FGF-8, and FGF-9 are mitogens for keratinocytes, mammary carcinoma cells, and astrocytes, respectively (10-12). Recent experiments indicate that several FGFs have bioactivities that were not evident during their initial identification. For example, FGF-2 can induce ventral mesoderm in Xenopus embryos (13,14), FGF-4 is involved in growth and patterning of the chicken limb bud (15), FGF-5 controls hair follicle cycling in the mouse (16), and FGF-8 can cause duplications of the embryonic chicken midbrain (17).The nine known FGFs are between 155 and 268 amino acid residues in length and share a conserved central region of -140 amino acids. This region forms a compact (3-barrel with 3-fold symmetry that is nearly identical in structure to the folded core of interleukins-la and -13 (18-21). FGF-1 and FGF-2 also resemble interleukin-1,B in lacking a classical signal sequence. Current data indicate that FGF-1 and FGF-2 are released from cells by a route that is distinct from the endoplasmic reticulum-Golgi secretory pathway (22, 23).FGF signaling is generally assumed to occur by activation of transmembrane tyrosine kinase receptors. Four FGF receptor (FGFR) genes have been identified thus far (24), and activating or inactivating receptor mutations have been described for a subset of these genes in both mice and humans. In the mouse, disruption of the FGFR1 or FGFR2 genes leads to early embryonic lethality (25,26), and disruption of FGFR3 leads to bone overgrowth (27,28). In humans, point mutations in FGFR1, FGFR2, and FGFR3 have been found in a variety of skeletal disorders (reviewed in ref. 29).In this paper we report the identification and characterization of four new mem...

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The Fibroblast Growth Factor Family An Overview

Cited by 103 publications

References 0 publications

Spatio‐temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis

Spatio‐temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis

Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

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