“…In fact, the variable expression of fibrinolysis system components in a given cancer may affect the prognosis. For instance, patients with greater expression of u-PA on breast cancer cells have shorter survival and increased chance of relapse (Bell, 1996).In renal cell carcinoma, it has been demonstrated that expression of plasminogen inhibitor-1 is an independent poor prognostic factor as it promotes tumor angiogenesis and metastasis (Choi et al,2011;Zubcaet al,2010). Therefore, changes in hematologic parameters are not only paraneoplstic features of RCC but also of prognostic value.…”