The fibrinolytic enzyme system in normal menstruation and excessive uterine bleeding and the effect of tranexamic acid

Dockeray, C. J.; Sheppard, B. L.; Daly, L.; Bonnar, J.

doi:10.1016/0028-2243(87)90156-0

Cited by 67 publications

(42 citation statements)

References 25 publications

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“…Furthermore, both plasminogen activator and plasmin levels were higher in the menstrual blood of patients with excessive uterine bleeding than in the menstrual blood of women with normal menstrual loss [17]. Thus, human menstrual blood loses thrombin generating activities and exhausts fibrinolytic proteins.…”

Section: Discussionmentioning

confidence: 91%

The role of blood in early endometrial–peritoneal interactions in a syngeneic mouse model of endometriosis

Kobayashi

Murakami

Yamamoto

et al. 2010

Reprod Medicine & Biology

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Purpose The aim of this study was to clarify the role of blood in the early stage of development of endometriotic lesions by developing a syngeneic transplantation model using immunocompetent mice. Methods Endometriotic lesions were induced in C57BL/6 mice by an intraperitoneal injection of endometrial fragments plus saline or endometrial fragments plus blood. Some endometrial fragments plus blood were injected with heparin, hirudin or tissue plasminogen activator (tPA). Endometriotic lesions on days 1, 3 and 5 were evaluated by gross and microscopic findings. Results The areas of endometriotic lesions in the blood group (6.4 ± 1.7 mm 2 ) were significantly larger than those in the saline group (0.5 ± 0.3 mm 2 ). The areas of endometriotic lesions were significantly reduced by the addition of heparin, hirudin or tPA. On day 1, endometriotic lesions in the blood group were observed on the peritoneum in five of the six mice. Endometriotic lesions on days 3 and 5 were significantly larger than those on day 1. On day 5, endometriotic lesions appeared cystic in all the mice. Conclusions Blood accelerates the early stage of development of endometriotic lesions when endometrial fragments plus blood are injected. Blood property might be involved in early endometrial-peritoneal interactions.

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Section: Discussionmentioning

confidence: 91%

The role of blood in early endometrial–peritoneal interactions in a syngeneic mouse model of endometriosis

Kobayashi

Murakami

Yamamoto

et al. 2010

Reprod Medicine & Biology

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“…In three studies, tranexamic acid was used to prevent bleeding: in one study after laser cervical conisation during pregnancy [16] and in two studies to prevent PPH in women with Factor XI (FXI) deficiency [21,22]. Four studies used tranexamic acid for antepartum bleeding [14,15,17,20].…”

Section: Observational Studiesmentioning

confidence: 98%

“…The fifth study by Békássy et al [16] reported the administration of tranexamic acid as prophylaxis for bleeding in pregnant women undergoing cervical conisation. Two studies [22,18] used tranexamic acid prophylactically in pregnant patients with FXI deficiency. Dosage and duration of administration of tranexamic acid ranged from 1 to 4 g and duration of treatment from 1 day to 12 weeks.…”

Section: Observational Studiesmentioning

confidence: 99%

Antifibrinolytic therapy with tranexamic acid in pregnancy and postpartum

Peitsidis¹,

Kadir²

2011

Expert Opinion on Pharmacotherapy

113

111

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The clinical studies suggest that tranexamic acid reduces the amount of blood loss after delivery during cesarean sections and vaginal deliveries, and reduces the requirement for blood transfusion. Tranexamic acid seems to be safe and effective in the prevention and management of bleeding during pregnancy. Further investigation and larger clinical trials with better design and methodological quality are required to confirm these findings.

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“…Tranexamic acid Increased uterine fibrinolytic activity is found in women with menorrhagia compared to those with normal menstrual loss; this increased fibrinolysis is most likely due to high levels of endometrium-derived plasmin and plasminogen activators [163,164]. Tranexamic acid is an antifibrinolytic agent that reversibly blocks lysine-binding sites on plasminogen and prevents fibrin degradation [165].…”

Section: Medical Treatment Of Menorrhagiamentioning

confidence: 99%

The obstetric and gynaecological management of women with inherited bleeding disorders – review with guidelines produced by a taskforce of UK Haemophilia Centre Doctors’ Organization

et al. 2006

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Summary. The gynaecological and obstetric management of women with inherited coagulation disorders requires close collaboration between obstetrician/ gynaecologists and haematologists. Ideally these women should be managed in a joint disciplinary clinic where expertise and facilities are available to provide comprehensive assessment of the bleeding disorder and a combined plan of management. The haematologist should arrange and interpret laboratory tests and make provision for appropriate replacement therapy. These guidelines have been provided for healthcare professionals for information and guidance and it is also intended that they are readily available for women with bleeding disorders.

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The fibrinolytic enzyme system in normal menstruation and excessive uterine bleeding and the effect of tranexamic acid

Cited by 67 publications

References 25 publications

The role of blood in early endometrial–peritoneal interactions in a syngeneic mouse model of endometriosis

The role of blood in early endometrial–peritoneal interactions in a syngeneic mouse model of endometriosis

Antifibrinolytic therapy with tranexamic acid in pregnancy and postpartum

The obstetric and gynaecological management of women with inherited bleeding disorders – review with guidelines produced by a taskforce of UK Haemophilia Centre Doctors’ Organization

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