The Fibrinolytic Activity of a Novel Protease Derived from a Tempeh Producing Fungus,Fusariumsp. BLB

Fibrinolytic Enzymes from Medicinal Mushrooms

“…BLB. The hydrolytic activity of FP toward synthetic peptide subtracts is higher than that of proteases from Bacillus subtilis natto, Aspergillus oryzae, Streptomyces griseus and commercial plasmin (Sugimoto et al, 2007). This development of FP from Fusarium sp.…”

“…The sources of these bioactive compounds include fruiting body, mycelia, cultivation broth, submerged cultivation mycelia and fermentation derivatives (Cheung, 1996;Fiore & Kakkar, 2003;Kwok et al, 2005;Sugimoto et al, 2007;Wang et al, 1995;Wong et al, 2011;Wu et al, 2010, Yamamoto et al, 2005Yoon et al, 2003). This chapter focuses on the fibrinolytic enzymes derived from medicinal mushrooms.…”

“…Most fermented foods are derived from raw materials such as beans, grains, fish, meat, vegetables, and dairy products. Fermentation is carried out by edible bacteria or fungi (Kim et al, 1996;Sugimoto et al, 2007;Sumi et al, 1987;Sumi et al, 1995;Wong & Mine, 2004). For example, the Bacillus genus contains microbial species that usually are used for fermentation during fermented-foods production.…”

“…In the last decade, technology for mushroom submerged path culture has been established in the laboratory and at an industrial level. Mushrooms (fungi) may generate a new generation (Sugimoto et al, 2007) * N means undetermined Table 1. Fibrinolytic enzymes derived from mushrooms when a fresh environment and nutrients are provided.…”

“…BLB (FP), and identified the N-terminal amino acid (Ueda et al, 2007). Sugimoto et al (2007) cloned an FP gene encoding a novel protease derived from Fusarium sp. BLB.…”