The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies

Mack, Ryan; Zhang, Lei; Sj, Peter Breslin; Zhang, Jiwang

doi:10.1007/s12015-021-10230-x

Cited by 10 publications

(15 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Murine studies have provided considerable insight into the changes in hematopoiesis during development and aging [ 13 , 40 , 41 ]. The proposed layered organization of the hematopoietic system sees overlapping waves of HPCs and HSCs tailored to meet the specific needs of the embryo and its development into adulthood [ 2 , 7 , 12 , 13 ].…”

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 99%

“…The first wave of primitive hematopoiesis originates in the murine yolk sac from about E7 (7 days post coitus; dpc), thus giving rise to nucleated erythroid cells, macrophages and megakaryocytes [ 42 , 43 , 44 , 45 , 46 ]. This is followed by a second wave of yolk sac hematopoiesis, termed pro-definitive or transient definitive hematopoiesis [ 2 , 7 , 13 ]. This coincides with the emergence of multipotent erythro-myeloid progenitors (EMP) from hemogenic endothelium (HE) at approximately E8–8.5 [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 99%

“…This coincides with the emergence of multipotent erythro-myeloid progenitors (EMP) from hemogenic endothelium (HE) at approximately E8–8.5 [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. Between E9.5–10.5, these EMPs seed the fetal liver, where they generate myeloid cells, including erythroid cells, macrophages and granulocytes, and potentially low numbers of innate immune cells [ 2 , 7 , 13 , 40 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 99%

“…Human development and aging are associated with significant changes in functional hematopoietic cell outputs from specific anatomical regions and hematopoietic tissues [ 1 , 2 , 3 , 4 ]. Importantly, a detailed knowledge of these changes under steady-state and perturbed conditions is critical to understanding hematological disorders and diseases that originate during embryonic, fetal and post-natal life [ 5 , 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…From this and other research, the concept of a layered hematopoietic system has emerged [ 2 , 12 , 13 ], with successive, but distinct, waves of hematopoietic stem cell (HSC)-independent hematopoietic progenitor cells (HPCs) originating from the yolk sac and embryo proper prior to the generation of definitive HSCs principally, although not exclusively, from the embryonic para-aortic splanchnopleural/aorta-gonad-mesonephros (P-Sp/AGM) region. Selective HPCs and HSCs then seed the fetal liver, where they mature and expand before HSCs colonize the fetal bone marrow, with bone marrow becoming the main source of HSCs after birth [ 1 , 2 , 3 , 7 ]. Nevertheless, significant challenges still exist in studying HSCs and lineage-restricted HPCs during human embryonic and fetal development and on aging.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging

Watt

Hua

Roberts

2022

IJMS

View full text Add to dashboard Cite

The past five decades have seen significant progress in our understanding of human hematopoiesis. This has in part been due to the unprecedented development of advanced technologies, which have allowed the identification and characterization of rare subsets of human hematopoietic stem and progenitor cells and their lineage trajectories from embryonic through to adult life. Additionally, surrogate in vitro and in vivo models, although not fully recapitulating human hematopoiesis, have spurred on these scientific advances. These approaches have heightened our knowledge of hematological disorders and diseases and have led to their improved diagnosis and therapies. Here, we review human hematopoiesis at each end of the age spectrum, during embryonic and fetal development and on aging, providing exemplars of recent progress in deciphering the increasingly complex cellular and molecular hematopoietic landscapes in health and disease. This review concludes by highlighting links between chronic inflammation and metabolic and epigenetic changes associated with aging and in the development of clonal hematopoiesis.

show abstract

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 99%

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 99%

Section: The Concept Of a Layered Hematopoietic Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging

Watt

Hua

Roberts

2022

IJMS

View full text Add to dashboard Cite

show abstract

The fetal programming effect of maternal immune activation (MIA) on the offspring’s immune system

Hofsink,

Groenink,

Plösch

2024

Semin Immunopathol

View full text Add to dashboard Cite

The first 1000 days of life is a critical period of development in which adverse circumstances can have long-term consequences for the child’s health. Maternal immune activation is associated with increased risk of neurodevelopmental disorders in the child. Aberrant immune responses have been reported in individuals with neurodevelopmental disorders. Moreover, lasting effects of maternal immune activation on the offspring’s immune system have been reported. Taken together, this indicates that the effect of maternal immune activation is not limited to the central nervous system. Here, we explore the impact of maternal immune activation on the immune system of the offspring. We first describe the development of the immune system and provide an overview of reported alterations in the cytokine profiles, immune cell profiles, immune cell function, and immune induction in pre-clinical models. Additionally, we highlight recent research on the impact of maternal COVID-19 exposure on the neonatal immune system and the potential health consequences for the child. Our review shows that maternal immune activation alters the offspring’s immune system under certain conditions, but the reported effects are conflicting and inconsistent. In general, epigenetic modifications are considered the mechanism for fetal programming. The available data was insufficient to identify specific pathways that may contribute to immune programming. As a consequence of the COVID-19 pandemic, more research now focuses on the possible health effects of maternal immune activation on the offspring. Future research addressing the offspring’s immune response to maternal immune activation can elucidate specific pathways that contribute to fetal immune programming and the long-term health effects for the offspring.

show abstract

Dynamics of human hematopoietic stem and progenitor cell differentiation to the erythroid lineage

Schippel

Sharma

2023

Experimental Hematology

View full text Add to dashboard Cite

The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies

Cited by 10 publications

References 217 publications

Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging

Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging

The fetal programming effect of maternal immune activation (MIA) on the offspring’s immune system

Dynamics of human hematopoietic stem and progenitor cell differentiation to the erythroid lineage

Contact Info

Product

Resources

About