The fetal fibronectin test: 25 years after its development, what is the evidence regarding its clinical utility? A systematic review and meta-analysis

Faron, Gilles; Balepa, L.; Parra, José Z.; Fils, Jean‐François; Gucciardo, Léonardo

doi:10.1080/14767058.2018.1491031

Cited by 15 publications

(13 citation statements)

References 402 publications

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“…For high-risk asymptomatic pregnant women, and especially for women with multiple pregnancies, the predictive value of the test was also too low for clinical practice. 17 Another review and meta-analysis did suggest that although management based on fFN results may reduce PTB, the evidence was found to be of low quality. 18 A prospective observational cohort study with 9410 nulliparous women of singleton pregnancies shows that quantitative vaginal fFN and serial transvaginal ultrasound cervical length had limited predictive value for PTB.…”

Section: Introductionmentioning

confidence: 99%

“…A systematic review and meta‐analysis found that fFN should not be used as a screening test for asymptomatic pregnant women. For high‐risk asymptomatic pregnant women, and especially for women with multiple pregnancies, the predictive value of the test was also too low for clinical practice 17 . Another review and meta‐analysis did suggest that although management based on fFN results may reduce PTB, the evidence was found to be of low quality 18 .…”

Section: Introductionmentioning

confidence: 99%

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Use of complete blood count for predicting preterm birth in asymptomatic pregnant women: A propensity score‐matched analysis

Zhu

Zhuo

et al. 2020

Clinical Laboratory Analysis

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Background Accurate prediction of preterm birth (PTB) is still difficult, mostly because of the multifactorial etiology of PTB. Previous studies have been mostly focused on the prediction of PTB in symptomatic women or those presenting with threatened preterm labor. We aimed to study whether complete blood count (CBC) parameters at 20‐30 weeks of pregnancy can predict asymptomatic PTB. Methods In this retrospective case‐control study, the preterm and term delivery groups were matched by propensity score‐matched (PSM) analysis. Baseline data and the CBC parameters examined at 20‐30 weeks of gestation were recorded. Results The combined marker of neutrophil‐to‐lymphocyte ratio (NLR), hemoglobin (HGB), and platelet distribution width (PDW) accurately predicts PTB at a cutoff value of 0.25, with sensitivity and specificity of 88.6% and 40.5% and negative and positive predictive value of 97.9% and 10.2%, respectively. Conclusion The combined marker of CBC parameters can supplement other markers to predict PTB about 10 weeks in advance. This combined marker had a very high negative predictive value for PTB. Therefore, in subjects with normal combined marker value, further screening tests for PTB may be eliminated unless clinical suspicion is high.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of complete blood count for predicting preterm birth in asymptomatic pregnant women: A propensity score‐matched analysis

Zhu

Zhuo

et al. 2020

Clinical Laboratory Analysis

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“…[300] MMPs -1, -2, -8, -9, -12 [125] Elastin-derived matrikine, VG-6 (VGVAPG), AG-9 (AGVPGLGVG) [125,241,301,302] Elastin receptor complex (ERC) [300] Fibrillin [298] ADAMTS -10, -6 [303] Integrins αVβ3, αVβ6, α5β1 [304,305] Fibronectins [29,[306][307][308][309] Yes MMPs -2, -3, -7, -10, -11 [297] Fibronectin fragments (FNFr) [310], anastellin [311], fibstatin [312] Integrins α5β1 [313], α9β1, α4β1, αv-integrins [309,314,315], growth factors and syndecans [316] Fibronectin ED-A [29] Integrins α9β1, α4β1, α5β1, αv-integrins [29,308,317] Marks tumor stroma [29,[306][307][308]315,[317][318][319][320] Fibronectin ED-B [29] Integrins α9β1, α4β1, α5β1, αv-integrins [29,308,317] Marks tumor stroma [29,[306][307][308]…”

Section: Elastic Fibrilsmentioning

confidence: 99%

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

Niland

Eble

2020

IJMS

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The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication between the various cellular and non-cellular components of the TME. The cells of the TME modify their surrounding cancer-characteristic ECM. This in turn provides feedback to them via cellular receptors, thereby regulating, together with cytokines and exosomes, differentiation processes as well as tumor progression and spread. Matrix remodeling is accomplished by altering the repertoire of ECM components and by biophysical changes in stiffness and tension caused by ECM-crosslinking and ECM-degrading enzymes, in particular matrix metalloproteinases (MMPs). These can degrade ECM barriers or, by partial proteolysis, release soluble ECM fragments called matrikines, which influence cells inside and outside the TME. This review examines the changes in the ECM of the TME and the interaction between cells and the ECM, with a particular focus on MMPs.

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“…The other method to improve the accuracy of threatened SPTL diagnosis in symptomatic women was measurement of fetal fibronectin (fFN). Systematic reviews and meta-analyses [8,9] found that fFN should not be used as a screening test, and its predictive value was also too low for clinical practice for high-risk pregnancies. These studies do not support routine application of these tests in the clinic of pregnancies at risk of SPTL [7][8][9].…”

Section: The Efficacy and Efficiency Of Uterocervical Angle Measuremementioning

confidence: 99%

The Efficacy and Efficiency of Uterocervical Angle Measurements to Predict Preterm Labor in Idiopathic Polyhydramnios Patients: A Prospective Cohort Study

Yenigül

Ercan

2020

Z Geburtshilfe Neonatol

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Introduction Uterocervical angle measurements in pregnant women with idiopathic polyhydramnios were appraised for their predictive value for spontaneous preterm labor. Material and Methods In this prospective study, we included nulliparous and multiparous pregnant women diagnosed with idiopathic polyhydramnios at 24?28 weeks at our polyclinic; the uterocervical angle and cervical length were measured by transvaginal ultrasound at the time of diagnosis. Routine pregnancy follow-up was done by our team and gestational age at delivery and maternal-fetal outcomes were noted. Results In total, 24 patients delivered before 37 weeks and 36 patients delivered at 37 weeks or later. Preterm labor subjects had larger UCA values (126.7?12.9? vs. 100.8?16.2?) and term labor patients had larger cervical length values (34.3?4.5 mm vs. 40.6?5.2 mm). In women with idiopathic polyhydramnios, the area under the curve for the uterocervical angle was 0.885 (p<0.001) and it was 0.823 for the cervical length (p<0.001). Discussion The uterocervical angle, a sagittal transvaginal cervical image measurement, is a practical method that successfully predicts spontaneous preterm labor risk in singleton pregnancies with idiopathic polyhydramnios. In addition, the uterocervical angle displayed greater sensitivity, but lower specificity, compared with cervical length measures.

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The fetal fibronectin test: 25 years after its development, what is the evidence regarding its clinical utility? A systematic review and meta-analysis

Cited by 15 publications

References 402 publications

Use of complete blood count for predicting preterm birth in asymptomatic pregnant women: A propensity score‐matched analysis

Use of complete blood count for predicting preterm birth in asymptomatic pregnant women: A propensity score‐matched analysis

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

The Efficacy and Efficiency of Uterocervical Angle Measurements to Predict Preterm Labor in Idiopathic Polyhydramnios Patients: A Prospective Cohort Study

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