The features of the crystal structure of the layered series hydrates of uridine-5′-monophosphate salts (UMPNa_x·yH₂O)

Abstract

There are five novel hydrates of uridine-5′-monophosphate salts (UMPNax·yH2O, x = 0–2). The novel crystals present a typical layered sandwich packing architecture that the UMP molecular layers alternate with water molecular layers.

Structural aspects of dehydration and rehydration in the adenosine 5′-diphosphate (ADP)–potassium–water system

“…Recently a paper was published on a series of hydrated uridine 5′-phosphates, Na x (UMP)•yH 2 O. 28 Some aspects of dynamics and transfer of solvent and sodium cations in solvent-nucleotide systems (disodium salts of adenine, guanosine, cytosine and uridine 5′phosphates, Na 2 (AMP) 35 have been studied. Therefore, attempts to perform post-crystallization dehydration, which enable obtaining new, including anhydrous, crystalline forms of nucleotides or their salts, may turn out to be extremely interesting.…”

“…Recently a paper was published on a series of hydrated uridine 5′-phosphates, Na x (UMP)· y H 2 O. 28 Some aspects of dynamics and transfer of solvent and sodium cations in solvent–nucleotide systems (disodium salts of adenine, guanosine, cytosine and uridine 5′-phosphates, Na 2 (AMP)·12H 2 O, 29 Na 2 (ATP)·2H 2 O and Na 2 (ATP)·3H 2 O, 30 Na 2 (GMP)·7H 2 O, 31 Na 2 (GMP)·4H 2 O, 32 Na 2 (CMP)·9.25H 2 O, Na 2 (CMP)·8.125H 2 O and Na 2 (CMP)·6.5H 2 O, 33 Na 2 (UMP)·7H 2 O, 31 and adenosine 3′:5′-cyclic phosphate sodium salts, Na(cAMP)·CH 3 OH·3H 2 O and Na(cAMP)·5H 2 O, 34 Na(cAMP)·4H 2 O and Na(cAMP)·2H 2 O) 35 have been studied. Therefore, attempts to perform post-crystallization dehydration, which enable obtaining new, including anhydrous, crystalline forms of nucleotides or their salts, may turn out to be extremely interesting.…”