The Features of the Course of Pregnancy, Delivery, Postpartum Period and State of New-Borns in Women With Genital HPV Infection

Abstract

Objective : to define the features of the course of pregnancy, delivery, postpartum period and state of newborns in female patients with genital HPV infection, depending on its form and viral load; to assess the factors of the course of gestation and delivery in the vertical transmission of neonatal persistence of HPV infection. Material and methods. The study involved 132 pregnant women with genital HPV infection, their babies immediately after birth (n = 107) and at the age of 6 months (n = 106). The comparison group included pregnant patients, women in delivery and postpartum period who were under supervision and who gave childbirth in Gomel region over 2011-2012 (30087 pregnancies, 33477 births). Results. Pregnancy in women with HPV infection is frequently complicated by the threat of miscarriage (p = 0.0016). The clinical manifestations of HPV infection showed no effect on the gestation. Patients with high HPV load (5 lg GE per 100,000 cells) had birth canal injuries (p = 0.029) 3 times more often. Pregnancy complicated by gestosis and anemia, as well as vaginal childbirth were risk factors for perinatal transmission of HPV. The course of pregnancy and delivery were not determining factors in the persistence of HPV in the baby`s upper airways. Conclusion. We have defined the features of the course of pregnancy and delivery in women with genital HPV infection (the threat of miscarriage, birth canal injury with high viral load of HPV), the factors of perinatal transmission (gestosis and anemia during pregnancy, vaginal delivery).