The feasibility of switching from <scp>IVF</scp> to <scp>IVM</scp> combined with all‐blastocyst‐culture and transfer for patients with ovarian hyperstimulation syndrome tendency

Zhao, Fanxuan; Lu, Xiaosheng; Gong, Chaochao; Hao, Xi Shan; Liu, Xiaoming; Zhao, Junzhao

doi:10.1002/ijgo.14160

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…We scheduled oocyte retrieval 16-18h later using a transvaginal ultrasound-guided puncture of the follicles. subsequently, the follicles are performed procedures as mentioned before (17). Intracytoplasmic sperm injection (ICSI) has been advocated as the preferred method for metaphase II stage oocytes fertilization(4).…”

Section: Ivf/m Cyclementioning

confidence: 99%

“…We suspected that IVF/M got less available blastocysts and high-quality blastocysts which eventually affect the cumulative birth rate. The future pro le for embryologists was to devote to the cultivation of blastocysts in IVF/M which was coincides with the conception of blastocyst-transferred in ART (17,22,27).…”

Section: General Characteristics Of Patients Are Displayed In Tablementioning

confidence: 99%

“…The last situation we want is canceling the cycle. Research results have also demonstrated that timely switching IVF to IVM is an option to reduce the canceled cycle in PCOS patients meeting unexpected poor ovarian stimulation (16,17).Thus IVF/M in prolonged protocol would be a popular option due to the frequent and widespread use of IVF in prolonged protocol. To explore the feasibility of IVF/M, we analyzed the results of 6-year of data from 444 PCOS patients prospectively recorded UPOR who underwent either IVM/F or IVF with prolonged protocol from a single center.…”

Section: Introductionmentioning

confidence: 99%

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The Feasibility of Switching IVF to IVM in PCOS Patients with Unexpected Poor Ovarian Response Who Underwent Prolonged Protocol

Wu,

Su,

et al. 2024

Preprint

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Background With the expanding utilization of prolonged protocol, switching from in vitro fertilization to in vitro maturation (IVF/M) was a choice to prevent ovarian hyperstimulation syndrome and to avoid cycle cancellation. Our aim was to explore the feasibility of IVF/M in polycystic ovarian syndrome (PCOS) patients with unexpected poor ovarian response (UPOR) underwent prolonged protocol by comparing with IVF. Methods A retrospective analysis was performed on PCOS patients who were treated with prolonged protocol from June 2016 to December 2022. A total of 444 patients were diagnosed with unexpected poor ovarian response during ovarian stimulation. 156 patients performed IVF/M and 288 patients were treated with IVF. Laboratorial and clinical outcomes were analyzed and compared in two Groups. Results The Positive β-hCG rate (57.9%), clinical pregnancy rate (52.6%), live birth rate (38.9%) in fresh embryo transfer and cumulative live birth rate (35.3%) in IVF/M Group were lower than those in IVF Group (76.1%,66.8%,53.3%, 67.7%, respectively;all P < 0.05). The number of oocytes retrieved, mature oocytes, 2 pronuclear zygotes, embryos on day3, available blastocysts and high-quality blastocysts in IVF/M Group were less than those in IVF Group (P < 0.001). IVF/M Group gained no case of ovarian hyperstimulation syndrome (OHSS) while 59 (20.5%) patients cancelled fresh embryo transfer for OHSS and 23 (8.0%) of them were moderate to severe OHSS in IVF Group (P < 0.05). The pregnancy and neonatal complications were comparable between two groups. No dominant risk factor was found for non-live birth in fresh embryo transfer cycle. The only independent risk factor for non-live birth in cumulative cycles was IVF/M protocol. (4.58, 95%CI:2.94–7.13, P < 0.001). Conclusion IVF/M was a complement feasible choice for PCOS with UPOR who underwent prolonged protocol. Though with a lower live birth rate compared with IVF, almost one third couples still could achieve live birth and avoid neither cycle cancellation nor OHSS.

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Section: Ivf/m Cyclementioning

confidence: 99%

Section: General Characteristics Of Patients Are Displayed In Tablementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Feasibility of Switching IVF to IVM in PCOS Patients with Unexpected Poor Ovarian Response Who Underwent Prolonged Protocol

Wu,

Su,

et al. 2024

Preprint

Self Cite

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“…Since then, more than 5000 live human births have occurred as a result of oocyte IVM [ 9 ]. In human ARTs, IVM is currently used in specific circumstances in which it is proposed in order to avoid side effects of gonadotropin administration, such as in patients at risk of ovarian hyperstimulation syndrome [ 10 , 11 ], or those requiring rapid fertility preservation strategies before undergoing chemo or radio therapy for estrogen-sensitive cancer [ 12 , 13 , 14 ]. Moreover, IVM allows for the minimization of COH adverse side effects in patients with polycystic ovarian syndrome and reduces the gonadotropin use and costs associated with drug use and patient monitoring [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating and Modelling an Engineered Millifluidic In Vitro Oocyte Maturation System Reproducing the Physiological Ovary Environment in the Sheep Model

Mastrorocco

Cacopardo²,

Temerario³

et al. 2022

Cells

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In conventional assisted reproductive technologies (ARTs), oocytes are in vitro cultured in static conditions. Instead, dynamic systems could better mimic the physiological in vivo environment. In this study, a millifluidic in vitro oocyte maturation (mIVM) system, in a transparent bioreactor integrated with 3D printed supports, was investigated and modeled thanks to computational fluid dynamic (CFD) and oxygen convection-reaction-diffusion (CRD) models. Cumulus-oocyte complexes (COCs) from slaughtered lambs were cultured for 24 h under static (controls) or dynamic IVM in absence (native) or presence of 3D-printed devices with different shapes and assembly modes, with/without alginate filling. Nuclear chromatin configuration, mitochondria distribution patterns, and activity of in vitro matured oocytes were assessed. The native dynamic mIVM significantly reduced the maturation rate compared to the static group (p < 0.001) and metaphase II (MII) oocytes showed impaired mitochondria distribution (p < 0.05) and activity (p < 0.001). When COCs were included in a combination of concave+ring support, particularly with alginate filling, oocyte maturation and mitochondria pattern were preserved, and bioenergetic/oxidative status was improved (p < 0.05) compared to controls. Results were supported by computational models demonstrating that, in mIVM in biocompatible inserts, COCs were protected from shear stresses while ensuring physiological oxygen diffusion replicating the one occurring in vivo from capillaries.

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Road to in vitro maturation (IVM), from basic science to an informed clinical practice

Makieva,

Fraire-Zamora,

Ammar

et al. 2024

Human Reproduction

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The feasibility of switching from IVF to IVM combined with all‐blastocyst‐culture and transfer for patients with ovarian hyperstimulation syndrome tendency

Cited by 4 publications

References 14 publications

The Feasibility of Switching IVF to IVM in PCOS Patients with Unexpected Poor Ovarian Response Who Underwent Prolonged Protocol

The Feasibility of Switching IVF to IVM in PCOS Patients with Unexpected Poor Ovarian Response Who Underwent Prolonged Protocol

Investigating and Modelling an Engineered Millifluidic In Vitro Oocyte Maturation System Reproducing the Physiological Ovary Environment in the Sheep Model

Road to in vitro maturation (IVM), from basic science to an informed clinical practice

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