The feasibility of replacing antibiotics by quaternary ammonium compounds in topical antimicrobial acne therapy

Gloor, M.; Schorch, B.; Hoeffler, U.

doi:10.1007/bf00407886

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…Thus, any new agent seeking to treat acne by reducing the P. acnes burden should not be cross-resistant to erythromycin, clindamycin, or tetracycline, the most commonly used antibiotics for acne treatment. Quaternary ammonium compounds showed the in vitro MICs comparable to relevant antibiotics used in acne treatment, suggesting the possibility of replacing antibiotics in the antimicrobial therapy of acne by quaternary ammonium compounds (18). Nanomaterials have unique structural properties, such as a large surface-area-to-mass ratio and high affinity of binding to surfaces.…”

mentioning

confidence: 93%

In Vitro Antibacterial Activity of NB-003 against Propionibacterium acnes

Pannu

McCarthy

Martin

et al. 2011

Antimicrob Agents Chemother

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NB-003 and NB-003 gel formulations are oil-in-water nanoemulsions designed for use in bacterial infections. In vitro susceptibility of Propionibacterium acnes to NB-003 formulations and comparator drugs was evaluated. Both NB-003 formulations were bactericidal against all P. acnes isolates, including those that were erythromycin, clindamycin, and/or tetracycline resistant. In the absence of sebum, the MIC 90 s/minimum bactericidal concentrations (MBC 90 s) for NB-003, NB-003 gel, salicylic acid (SA), and benzoyl peroxide (BPO) were 0.5/2.0, 1.0/2.0, 1,000/2,000, and 50/200 g/ml, respectively. In the presence of 50% sebum, the MIC 90 s/MBC 90 s of NB003 and BPOs increased to 128/1,024 and 400/1,600 g/ml, respectively. The MIC 90 s/MBC 90 s of SA were not significantly impacted by the presence of sebum. A reduction in the MBC 90 s for NB-003 and BPO was observed when 2% SA or 0.5% BPO was integrated into the formulation, resulting in MIC 90 s/MBC 90 s of 128/256 g/ml for NB003 and 214/428 g/ml for BPO. The addition of EDTA enhanced the in vitro efficacy of 0.5% NB-003 in the presence or absence of 25% sebum. The addition of 5 mM EDTA to each well of the microtiter plate resulted in a >16-and >256-fold decrease in MIC 90 and MBC 90 , yielding a more potent MIC 90 /MBC 90 of <1/<1 g/ml. The kinetics of bactericidal activity of NB-003 against P. acnes were compared to those of a commercially available product of BPO. Electron micrographs of P. acnes treated with NB-003 showed complete disruption of bacteria. Assessment of spontaneous resistance of P. acnes revealed no stably resistant mutant strains.

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confidence: 93%

In Vitro Antibacterial Activity of NB-003 against Propionibacterium acnes

Pannu

McCarthy

Martin

et al. 2011

Antimicrob Agents Chemother

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“…It is also a cationic microbicide and exhibits a wide range of antimicrobial properties against bacteria, fungi, and viruses. It has been used as a bactericidal since 1935 [44], as a preservative for ophthalmic solutions since 1979 [45], and is widely used in the textile industry as an insecticide or antimicrobial [46,47]. It is extremely effective against the most important viruses: the common flu, measles, rabies, herpes simplex, yellow fever, Venezuelan equine encephalitis, Japanese encephalitis B, adenovirus type 7, and meningitis [48].…”

Section: And Fragmentsmentioning

confidence: 99%

Hydrophilic Antimicrobial Coatings for Medical Leathers from Silica-Dendritic Polymer-Silver Nanoparticle Composite Xerogels

et al. 2022

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Hybrid organic-inorganic (dendritic polymer-silica) xerogels containing silver nanoparticles (Ag Nps) were developed as antibacterial leather coatings. The preparation method is environmentally friendly and is based on two biomimetic reactions. Silica gelation and spontaneous Ag Nps formation were both mediated by hyperbranched poly (ethylene imine) (PEI) scaffolds of variable Mw (2000–750,000). The formation of precursor hydrogels was monitored by dynamic light scattering (DLS). The chemical composition of the xerogels was assessed by infrared spectroscopy (IR) and energy-dispersive X-ray spectroscopy (EDS), while the uniformity of the coatings was established by scanning electron microscopy (SEM). The release properties of coated leather samples and their overall behavior in water in comparison to untreated analogs were investigated by Ultraviolet-Visible (UV-Vis) spectroscopy. Antibacterial activity was tested against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and antibiofilm properties against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Acinetobacter baumannii, and Enterococcus faecalis, while the SARS-CoV-2 clinical isolate was employed for the first estimation of their antiviral potential. Toxicity was evaluated using the Jurkat E6.1 cell line. Finally, water-contact angle measurements were implemented to determine the enhancement of the leather surface hydrophilicity caused by these composite layers. The final advanced products are intended for use in medical applications.

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“…It is also a cationic microbicide and exhibits a wide range of antimicrobial properties against bacteria, fungi, and viruses. It has been used as a bactericidal since 1935 [37], as a preservative for ophthalmic solutions since 1979 [38], and is widely used in the textile industry as an insecticide or antimicrobial [39][40]. It is extremely effective against the most important viruses: common flu, measles, rabies, herpes simplex, yellow fever, Venezuelan equine encephalitis, Japanese encephalitis B, adenovirus type 7, and meningitis [41].…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic Antimicrobial Coatings for Medical Leathers from Silica-Dendritic Polymer-Silver Nanoparticle Composite Xerogels

Arkas¹,

Kythreoti²,

Favvas³

et al. 2022

Preprint

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Hybrid organic-inorganic (dendritic polymer-silica) xerogels containing silver nanoparticles (Ag-Nps) were developed as antibacterial leather coatings. The preparation method is environmentally friendly, based on two biomimetic reactions. Silica gelation and spontaneous (Ag-Np) formation were both mediated by hyperbranched poly (ethylene imine) (PEI) scaffolds of variable Mw (2000-750000). The formation of precursor hydrogels was monitored by dynamic light scattering (DLS). The chemical composition of the xerogels was assessed by Infra-Red Spectroscopy (IR) and Energy-dispersive X-ray spectroscopy (EDS) while the uniformity of the coatings was established by scanning electron microscopy (SEM). Release properties of coated leather samples and overall behaviour in water in comparison to untreated analogs were investigated by UV-Vis spectroscopy. Antibacterial activity was tested towards Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and antibiofilm properties against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Acinetobacter baumannii, Enterococcus faecalis while SARS-Cov-2 clinical isolate was employed for the first estimation of their antiviral potential. Toxicity was evaluated using the Jurkat E6.1-cell line. Finally, water contact angle measurements were implemented to determine the enhancement of the leather surface hydrophilicity caused by these composite layers. The final advanced products are intended for use in medical applications.

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The feasibility of replacing antibiotics by quaternary ammonium compounds in topical antimicrobial acne therapy

Cited by 7 publications

References 7 publications

In Vitro Antibacterial Activity of NB-003 against Propionibacterium acnes

In Vitro Antibacterial Activity of NB-003 against Propionibacterium acnes

Hydrophilic Antimicrobial Coatings for Medical Leathers from Silica-Dendritic Polymer-Silver Nanoparticle Composite Xerogels

Hydrophilic Antimicrobial Coatings for Medical Leathers from Silica-Dendritic Polymer-Silver Nanoparticle Composite Xerogels

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