“…The movement of these particles causes changes in optical power and speckle pattern blurring, which can be used to estimate blood flow through speckle contrast 𝐾 𝑠 . The relationship between contrast and flow depends on the scattering framework, particle motion, and the presence of static scattering with the relationship of 1/𝐾 𝑠 2 = BFI [19][20][21][22][23][24][25][26][27][28][29], where BFI is the blood flow index, which can be described as an estimation of perfusion, according to the speckle contrast optical spectroscopy theory. This method is easy to use and allows for real-time data processing, which is why it is widely used in many SCOS applications.…”
Section: Fiber-based Speckle Contrast Optical Spectroscopy Setup and ...mentioning
confidence: 99%
“…We used fiber camera-based speckle contrast optical spectroscopy (SCOS) [19][20][21][22][23][24][25][26][27][28][29] to measure blood flow in deep tissue. The standard technology for this is continuous wave diffuse correlation spectroscopy (DCS), which has limitations in terms of cost, speed, and the number of detectors that can be used.…”
Neurocritical care focuses on monitoring cerebral blood flow (CBF) to prevent secondary brain injuries before damage becomes irreversible. Thus, there is a critical unmet need for continuous neuromonitoring methods to quantify CBF within the vulnerable cortex continuously and non-invasively. Animal models and imaging biomarkers can provide valuable insights into the mechanisms and kinetics of head injury, as well as insights for potential treatment strategies. For this purpose, we implemented an optical technique for continuous monitoring of blood flow changes after a closed head injury in a mouse model, which is based on laser speckle contrast imaging and a fiber camera-based approach. Our results indicate a significant decrease (~10%, p-value < 0.05) in blood flow within 30 min of a closed head injury. Furthermore, the low-frequency oscillation analysis also indicated much lower power in the trauma group compared to the control group. Overall, blood flow has the potential to be a biomarker for head injuries in the early phase of a trauma, and the system is useful for continuous monitoring with the potential for clinical translation.
“…The movement of these particles causes changes in optical power and speckle pattern blurring, which can be used to estimate blood flow through speckle contrast 𝐾 𝑠 . The relationship between contrast and flow depends on the scattering framework, particle motion, and the presence of static scattering with the relationship of 1/𝐾 𝑠 2 = BFI [19][20][21][22][23][24][25][26][27][28][29], where BFI is the blood flow index, which can be described as an estimation of perfusion, according to the speckle contrast optical spectroscopy theory. This method is easy to use and allows for real-time data processing, which is why it is widely used in many SCOS applications.…”
Section: Fiber-based Speckle Contrast Optical Spectroscopy Setup and ...mentioning
confidence: 99%
“…We used fiber camera-based speckle contrast optical spectroscopy (SCOS) [19][20][21][22][23][24][25][26][27][28][29] to measure blood flow in deep tissue. The standard technology for this is continuous wave diffuse correlation spectroscopy (DCS), which has limitations in terms of cost, speed, and the number of detectors that can be used.…”
Neurocritical care focuses on monitoring cerebral blood flow (CBF) to prevent secondary brain injuries before damage becomes irreversible. Thus, there is a critical unmet need for continuous neuromonitoring methods to quantify CBF within the vulnerable cortex continuously and non-invasively. Animal models and imaging biomarkers can provide valuable insights into the mechanisms and kinetics of head injury, as well as insights for potential treatment strategies. For this purpose, we implemented an optical technique for continuous monitoring of blood flow changes after a closed head injury in a mouse model, which is based on laser speckle contrast imaging and a fiber camera-based approach. Our results indicate a significant decrease (~10%, p-value < 0.05) in blood flow within 30 min of a closed head injury. Furthermore, the low-frequency oscillation analysis also indicated much lower power in the trauma group compared to the control group. Overall, blood flow has the potential to be a biomarker for head injuries in the early phase of a trauma, and the system is useful for continuous monitoring with the potential for clinical translation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.