The feasibility of a nano-interial measurement unit that uses chemistry to record position

Tanner, Maria E.; Protz, Jonathan M.

doi:10.1117/12.719801

Cited by 4 publications

(4 citation statements)

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“…To achieve nanoscale sizes, all BNS components should be able to operate at nanoscale. A variety of nanoscale gyroscopes and accelerometers have already been developed in recent years [25], [26]. One example of a nanoscale gyroscope was presented by Song et al [27].…”

Section: Localization Based On Inertial Positioningmentioning

confidence: 99%

In-body Bionanosensor Localization for Anomaly Detection via Inertial Positioning and THz Backscattering Communication

Simonjan¹,

Unluturk²,

Akyildiz³

2021

Preprint

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Nanotechnology is enabling the development of a new generation of devices which are able to sense, process and communicate, while being in the scale of tens to hundreds of cubic nanometers. Such small, imperceptible devices enhance not only current applications but enable entirely new paradigms especially for in-body environments. This paper introduces a localization and tracking concept for bionanosensors floating in the human bloodstream to detect anomalies in the body. Besides the nanoscale sensors, the proposed system also comprises macroscale anchor nodes attached to the skin of the monitored person. To realize autonomous localization and resource-efficient wireless communication between sensors and anchors, we propose to exploit inertial positioning and sub-terahertz backscattering. The proposed system is a first step towards early disease detection as it aims at localizing body regions which show anomalies. Simulations are conducted to enable a systematical evaluation on the feasibility of the approach.

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Section: Localization Based On Inertial Positioningmentioning

confidence: 99%

In-body Bionanosensor Localization for Anomaly Detection via Inertial Positioning and THz Backscattering Communication

Simonjan¹,

Unluturk²,

Akyildiz³

2021

Preprint

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“…Chemical recording has been proposed in conjunction with mechanical sensing of acceleration [1,2]. The mechanical characteristics of the device determine the sensing of the acceleration experienced at a particular time.…”

Section: Chemical Recordingmentioning

confidence: 99%

“…The system of equations for the heat transfer model, where the track is divided into a high temperature region and a low temperature region, is (1) where A n , B n , c n , and d n are Fourier expansion coefficients, A c is the cross-sectional area of the channel, D H is the hydraulic diameter, L is the length, m o , ρ ,o , T o, and u o are constants and represent a biased background value for mass flow rate, density, temperature, and fluid velocity respectively [3].…”

Section: Mechanical Sensingmentioning

confidence: 99%

Analysis and feasibility of chemical recording using thermosensitive liposomes

Tanner

Vasievich²,

Protz

2007

BioMEMS and Nanotechnology III

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A new generation of inertial measurement technology is being developed enabling a 10-micron particle to be "aware" of its geospatial location and respond to this information. The proposed approach combines an inertially-sensitive nanostructure or nano fluid/structure system with a nano-sized chemical reactor that functions as an analog computer. Originally, a cantilever-controlled valve used to control a first order chemical reaction was proposed. The feasibility of this concept was evaluated, resulting in a device with significant size reductions, comparable gain, and lower bandwidth than current accelerometers. New concepts with additional refinements have been investigated. Buoyancy-driven convection coupled with a chemical recording technique is explored as a possible alternative. Using a micro-track containing regions of different temperatures and thermosensitive liposomes (TSL), a range of accelerations can be recorded and the position determined. Through careful design, TSL can be developed that have unique transition temperatures and each class of TSL will contain a unique DNA sequence that serves as an identifier. Acceleration can be detected through buoyancy-driven convection. As the liposomes travel to regions of warmer temperature, they will release their contents at the recording site, thus documenting the acceleration. This paper will outline the concept and present the feasibility.

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“…The concentration of the resulting product then provided a measure of position. The feasibility of this concept was evaluated, resulting in a device with significant size reductions, comparable gain, and lower bandwidth than current accelerometers 1,2 . The concept then evolved to use buoyancy-driven convection 3 .…”

Section: Introductionmentioning

confidence: 99%

Experimental results of chemical recording using thermally sensitive liposomes

Tanner

Vasievich²,

Protz

2008

SPIE Proceedings

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A new generation of inertial measurement technology is being developed enabling a 10-micron particle to be "aware" of its geospatial location and respond to this information. The proposed approach combines an inertially-sensitive nanostructure or nano fluid/structure system with a nano-sized chemical reactor that functions as an analog computer. By using chemistry to perform the necessary computational steps in our device, it is possible to overcome traditional limitations on device size. The proposed nanodevice utilizes mechanical sensing and chemical recording to record the time history of various state variables. Using a micro-track containing regions of different temperatures and thermallysensitive liposomes (TSL), a range of accelerations can be recorded and the position determined. Through careful design, TSL can be developed that have unique transition temperatures and each class of TSL will contain a unique DNA sequence that serves as an identifier. Acceleration can be detected through buoyancy-driven convection. As the liposomes travel to regions of warmer temperature, they will release their contents at the recording site, thus documenting the acceleration. This paper will present the initial proof-of-concept experimental results achieved from chemical recording of the state variable temperature. The experiment focuses on the liposome release of the DNA due to temperature variations and subsequent binding and recording of the time history. These results prove the feasibility of this method of sensing and recording of the history of state variables.

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The feasibility of a nano-interial measurement unit that uses chemistry to record position

Cited by 4 publications

References 0 publications

In-body Bionanosensor Localization for Anomaly Detection via Inertial Positioning and THz Backscattering Communication

In-body Bionanosensor Localization for Anomaly Detection via Inertial Positioning and THz Backscattering Communication

Analysis and feasibility of chemical recording using thermosensitive liposomes

Experimental results of chemical recording using thermally sensitive liposomes

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