The feasibility and efficacy of short-term visual-motor training in pediatric posterior fossa tumor survivors

Kasatkin, Vladimir; Deviaterikova, Alena; Shurupova, Marina A.; Karelin, Alexander

doi:10.23736/s1973-9087.21.06854-4

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…Even though in most included studies neuropsychological tests were performed to assess the outcomes, the test batteries and subtests used were different. Memory was assessed by Automated Working Memory Assessment (AWMA) ( 22 ), Cambridge Neuropsychological Test Automated Battery (CANTAB) ( 17 – 19 ), Children’s Auditory Verbal Learning Test-2 (CAVLT-2) ( 11 ), List Sorting Working Memory (LSWM) ( 11 , 15 ), Picture Sequence Memory Test (PSM) from the NIH toolbox ( 11 , 15 ), Rey Auditory Verbal Learning Test (RAVLT) ( 11 , 14 ), Wechsler Intelligence Scale for Children (WISC-III/IV) ( 12 , 14 , 20 ), or Wide Range Assessment of Memory and Learning (WRAML-2) ( 20 , 23 ). Processing speed and attention was assessed mainly by the CANTAB test battery ( 11 , 18 , 19 ).…”

Section: Resultsmentioning

confidence: 99%

“…The 14 included publications studied different types of interventions to prevent or improve neurocognitive late-effects in children or adolescents diagnosed with CNS tumors. The reported interventions can be divided into pharmacological interventions ( 11 , 23 ), exercise interventions ( 16 , 18 , 19 ), online cognitive training ( 12 , 15 , 17 , 20 , 22 ), and behavioral interventions ( 13 , 14 , 21 , 24 ). The intervention and outcomes are summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Five publications reported on online cognitive training ( 12 , 15 , 17 , 20 , 22 ). Most of them reported on commercially available online programs.…”

Section: Resultsmentioning

confidence: 99%

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Interventions to improve neurocognitive late-effects in pediatric and adolescent CNS tumor patients and survivors - a systematic review

et al. 2023

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IntroductionSurvival of children and adolescents diagnosed with central nervous system (CNS) tumors massively improved over the last decades due to better diagnostics, treatment, and supportive care. However, morbidity is still the highest of all cancer entities in this age group with neurocognitive late-effects being one of the most severe.AimWith this systematic review, we aim to summarize interventions designed to prevent or improve neurocognitive late-effects in CNS tumor patients.MethodWe searched PubMed on August 16th 2022 and included publications studying interventions for neurocognitive late-effects in pediatric and adolescent patients and survivors diagnosed with a CNS tumor. We included any form of neurocognitive intervention during treatment or following treatment completion. We considered all types of studies except for expert opinions and case reports.ResultsThe literature search resulted in 735 publications. We included 43 publications in the full text screening and 14 met our inclusion criteria. Of those, two assessed the impact of pharmacological interventions, three of exercise interventions, five of online cognitive training, and four assessed behavioral interventions. Different neuropsychological test batteries and imaging were used to measure the impact of the respective interventions. Most studies showed a positive impact of the interventions in single to several of the subtests used.ConclusionWe found several intervention studies indicating improvement of neurocognitive problems in children and adolescent CNS tumor survivors. In this population exercise interventions or online cognitive training might mitigate or improve neurocognitive late-effects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Interventions to improve neurocognitive late-effects in pediatric and adolescent CNS tumor patients and survivors - a systematic review

et al. 2023

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“…Despite reducing RT dose, despite avoiding some drugs, despite applying prophylactic treatments and despite technological advances, treatment-related toxicity remains significant and most long-term survivors experience side effects. Cognitive and behavioral therapies have been applied with positive results, especially in young children, and should be applied more widely ( 120 , 121 ). Other interventions have been proven ineffective ( 122 ).…”

Section: Discussionmentioning

confidence: 99%

Questions and answers in the management of children with medulloblastoma over the time. How did we get here? A systematic review

Osuna-Marco,

Martín-López,

Tejera

et al. 2023

Front. Oncol.

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IntroductionTreatment of children with medulloblastoma (MB) includes surgery, radiation therapy (RT) and chemotherapy (CT). Several treatment protocols and clinical trials have been developed over the time to maximize survival and minimize side effects.MethodsWe performed a systematic literature search in May 2023 using PubMed. We selected all clinical trials articles and multicenter studies focusing on MB. We excluded studies focusing exclusively on infants, adults, supratentorial PNETs or refractory/relapsed tumors, studies involving different tumors or different types of PNETs without differentiating survival, studies including <10 cases of MB, solely retrospective studies and those without reference to outcome and/or side effects after a defined treatment.Results1. The main poor-prognosis factors are: metastatic disease, anaplasia, MYC amplification, age younger than 36 months and some molecular subgroups. The postoperative residual tumor size is controversial.2. MB is a collection of diseases.3. MB is a curable disease at diagnosis, but survival is scarce upon relapse.4. Children should be treated by experienced neurosurgeons and in advanced centers.5. RT is an essential treatment for MB. It should be administered craniospinal, early and without interruptions.6. Craniospinal RT dose could be lowered in some low-risk patients, but these reductions should be done with caution to avoid relapses.7. Irradiation of the tumor area instead of the entire posterior fossa is safe enough.8. Hyperfractionated RT is not superior to conventional RT9. Both photon and proton RT are effective.10. CT increases survival, especially in high-risk patients.11. There are multiple drugs effective in MB. The combination of different drugs is appropriate management.12. CT should be administered after RT.13. The specific benefit of concomitant CT to RT is unknown.14. Intensified CT with stem cell rescue has no benefit compared to standard CT regimens.15. The efficacy of intraventricular/intrathecal CT is controversial.16. We should start to think about incorporating targeted therapies in front-line treatment.17. Survivors of MB still have significant side effects.ConclusionSurvival rates of MB improved greatly from 1940-1970, but since then the improvement has been smaller. We should consider introducing targeted therapy as front-line therapy.

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Effects of cognitive-motor intervention for pediatric posterior fossa tumor survivors: results of a pilot study

Kasatkin,

Romanova,

Glebova

et al. 2024

J Neurooncol

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The feasibility and efficacy of short-term visual-motor training in pediatric posterior fossa tumor survivors

Cited by 6 publications

References 47 publications

Interventions to improve neurocognitive late-effects in pediatric and adolescent CNS tumor patients and survivors - a systematic review

Interventions to improve neurocognitive late-effects in pediatric and adolescent CNS tumor patients and survivors - a systematic review

Questions and answers in the management of children with medulloblastoma over the time. How did we get here? A systematic review

Effects of cognitive-motor intervention for pediatric posterior fossa tumor survivors: results of a pilot study

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