The Fcγ Receptor Genotype as a Risk Factor for Generalized Early‐Onset Periodontitis in Japanese Patients

Kobayashi, Tetsuo; Sugita, Noriko; Pol, W‐Ludo van der; Nunokawa, Yasuko; Westerdaal, N. A. C.; Yamamoto, Kouji; Winkel, Jan G. J. van de; Yoshie, Hiromasa

doi:10.1902/jop.2000.71.9.1425

Cited by 77 publications

(87 citation statements)

References 59 publications

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“…The distribution observed was similar to that in previous reports of the Japanese population (allelic frequency of FCGR3A-158F was 0.72-0.74; refs. 31,32). The distribution of FCGR3A genotype among various subgroups based on clinical backgrounds is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients

Suzuki

Niwa

Saji

et al. 2007

Clinical Cancer Research

102

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Purpose: Removal of fucose residues from the oligosaccharides of human antibody is a powerful approach to enhance antibody-dependent cellular cytotoxicity (ADCC), a potential important antitumor mechanism of therapeutic antibodies. To provide clinically relevant evidence of this mechanism, we investigated ADCC of a fucose-negative version of trastuzumab [anti^human epidermal growth factor receptor 2 (HER2) humanized antibody] using peripheral blood mononuclear cells (PBMC) from breast cancer patients as effector cells. Experimental Design: Thirty volunteers, including 20 breast cancer patients and 10 normal healthy control donors, were recruited randomly, and aliquots of peripheral blood were collected. ADCC of commercial trastuzumab (fucosylated) and its fucose-negative version were measured using PBMCs drawn from the volunteers as effector cells and two breast cancer cell lines with different HER2 expression levels as target cells. Relationships between cytotoxicity and characteristics of the patients, such as content of natural killer cells in PBMCs, type of therapy, FCGR3A genotypes, etc. were also analyzed. Results: ADCC was significantly enhanced with the fucose-negative antibody compared with the fucose-positive antibody using PBMCs from either normal donors or breast cancer patients. Enhancement of ADCC was observed irrespective of the various clinical backgrounds of the patients, even in the chemotherapy cohort that presented with a reduced number of natural killer cells and weaker ADCC. Conclusions: This preliminary study suggests that the use of fucose-negative antibodies may improve the therapeutic effects of anti-HER2 therapy for patients independent of clinical backgrounds.

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Section: Resultsmentioning

confidence: 99%

A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients

Suzuki

Niwa

Saji

et al. 2007

Clinical Cancer Research

102

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“…FcgRIIIB-NA2 allele was also associated with the onset of AGP, which is consistent with our previous results. 21 The haplotype formed by FcgRIIBÀ232T and FcgRIIIB-NA2 did not exist in controls, suggesting a weak but significant positive linkage disequilibrium between FcgRIIBÀ232I and FcgRIIIB-NA2, whereas 232I-NA1 was the most common haplotype in controls and patients. Additionally, in AGP patients, the FcgRIIBÀ232T allele formed a haplotype with the FcgRIIIB-NA2 allele (the estimated haplotype frequency of the 232T-NA2 was 14.8%).…”

Section: Discussionmentioning

confidence: 98%

FcγRIIB gene polymorphisms in Japanese periodontitis patients

et al. 2003

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Human type II low-affinity receptor for immunoglobulin G (FcgRII) constitutes a clustered gene family consisting of FcgRIIA, IIB and IIC genes. FcgRIIB is unique in its ability to transmit inhibitory signals in B cells via immunoreceptor tyrosine-based inhibitory motif (ITIM). B-cell activation and subsequent elevated production of IgG are the immunopathological features of inflammatory disease such as periodontitis. To determine whether an association with periodontitis susceptibility exists, genetic polymorphisms of FcgRIIB were examined in Japanese patients with aggressive periodontitis (AGP) and chronic periodontitis (CP), and in the race-matched healthy controls (HCs). A significant difference was observed in the distribution of FcgRIIBÀ232I/T allele (exon 5) between the AGP and HC groups, with enrichment of the 232T in the AGP group (P¼0.006). In addition, the FcgRIIB-nt 646À184A/G allele (intron 4) distribution was significantly different between the CP and HC groups, with enrichment of the nt 646À184A in the CP group (P¼0.011). These results document the association of FcgRIIB gene polymorphisms with susceptibility to periodontitis in the Japanese.

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“…8,9 In Japanese patients, FcγRIIIb NA2 allele was associated with Generalized (G)-EOP 17 and was found more often in adult periodontitis with disease recurrence. 29 The combined carriage rate of both FcγRIIIb NA2 and FcγRIIIa-158F gene was more frequently detected in G-EOP over healthy controls.…”

Section: Distribution Of Fcγriii Genotypes and Allelesmentioning

confidence: 99%

“…29 The combined carriage rate of both FcγRIIIb NA2 and FcγRIIIa-158F gene was more frequently detected in G-EOP over healthy controls. 17 In African Americans, an association between the FcγRIIIb and localized AgP has been found. 16 However, In this study, no significant association was observed between the FcγRIIIb polymorphism and AgP.…”

Section: Distribution Of Fcγriii Genotypes and Allelesmentioning

confidence: 99%

The Fcγ receptor III genotype as a risk factor for aggressive periodontitis in Korean patients

Kim

Shin

Kim

et al. 2006

J Korean Acad Periodontol

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The Fcγ Receptor Genotype as a Risk Factor for Generalized Early‐Onset Periodontitis in Japanese Patients

Abstract: This study indicates that the FcgammaRIIIb-NA2 allele and possibly FcgammaRIIIa-158F could be associated with susceptibility to G-EOP in Japanese patients.

Cited by 77 publications

References 59 publications

A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients

A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients

FcγRIIB gene polymorphisms in Japanese periodontitis patients

The Fcγ receptor III genotype as a risk factor for aggressive periodontitis in Korean patients

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