The Fatty Acid Amide Hydrolase in Lymphocytes from Sedentary and Active Subjects

Gasperi, Valeria; Ceci, Roberta; Tantimonaco, Mirko; Talamonti, Emanuela; Battista, Natalia; Parisi, Attilio; Florio, Rita; Sabatini, Stefania; Rossi, Antonello; Maccarrone, Mauro

doi:10.1249/mss.0b013e3182a10ce6

Cited by 29 publications

(20 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could be because the eCB levels in this study were measured at the basal state, while Heyman et al [61] measured eCB levels after intense exercise. In support to our data, regarding the specific relationships between some NAEs and PA, Gasperi et al [62] found increased activity of FAAH in the lymphocytes of physically active subjects at resting condition. It must be noted that blood eCB levels represent the spillover from many sources and it is not possible to differentiate the tissue of origin.…”

Section: Discussionsupporting

confidence: 92%

Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament

et al. 2014

View full text Add to dashboard Cite

BackgroundEndocannabinoids and temperament traits have been linked to both physical activity and body mass index (BMI) however no study has explored how these factors interact in females. The aims of this cross-sectional study were to 1) examine differences among distinct BMI groups on daytime physical activity and time spent in moderate-vigorous physical activity (MVPA), temperament traits and plasma endocannabinoid concentrations; and 2) explore the association and interaction between MVPA, temperament, endocannabinoids and BMI.MethodsPhysical activity was measured with the wrist-worn accelerometer Actiwatch AW7, in a sample of 189 female participants (43 morbid obese, 30 obese, and 116 healthy-weight controls). The Temperament and Character Inventory-Revised questionnaire was used to assess personality traits. BMI was calculated by bioelectrical impedance analysis via the TANITA digital scale. Blood analyses were conducted to measure levels of endocannabinoids and endocannabinoid-related compounds. Path-analysis was performed to examine the association between predictive variables and MVPA.ResultsObese groups showed lower MVPA and dysfunctional temperament traits compared to healthy-weight controls. Plasma concentrations of 2-arachidonoylglyceryl (2-AG) were greater in obese groups. Path-analysis identified a direct effect between greater MVPA and low BMI (b = −0.13, p = .039) and high MVPA levels were associated with elevated anandamide (AEA) levels (b = 0.16, p = .049) and N-oleylethanolamide (OEA) levels (b = 0.22, p = .004), as well as high Novelty seeking (b = 0.18, p<.001) and low Harm avoidance (b = −0.16, p<.001).ConclusionsObese individuals showed a distinct temperament profile and circulating endocannabinoids compared to controls. Temperament and endocannabinoids may act as moderators of the low MVPA in obesity.

show abstract

Section: Discussionsupporting

confidence: 92%

Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament

et al. 2014

View full text Add to dashboard Cite

show abstract

“…We have shown, in a previous report, that physical activity level (Pittaluga et al 2006) may influence cellular response to oxidative stress. Besides, we also documented that lifestyle (e.g., sedentary vs. active) (Gasperi et al 2014) has an impact on endocannabinoid system, a ubiquitous and complex signaling network involved in various biological processes including those triggered by physical exercise. It is well known that contractile activity increases ROS, which are normally partially neutralized by the cellular antioxidant buffering capacity.…”

Section: Discussionmentioning

confidence: 78%

Effects of tadalafil administration on plasma markers of exercise-induced muscle damage, IL6 and antioxidant status capacity

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Interestingly, high circulating AEA concentrations are also associated with high BMI. On the other hand, no differences in basal concentrations of AEA and 2-AG were found between active and sedentary NW men in another study (Gasperi et al, 2014).…”

Section: Circulating Endocannabinoids and Exercisementioning

confidence: 77%

Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

Hillard

2017

Neuropsychopharmacol.

329

241

View full text Add to dashboard Cite

The goal of this review is to summarize studies in which concentrations of circulating endocannabinoids in humans have been examined in relationship to physiological measurements and pathological status. The roles of endocannabinoids in the regulation of energy intake and storage have been well studied and the data obtained consistently support the hypothesis that endocannabinoid signaling is associated with increased consumption and storage of energy. Physical exercise mobilizes endocannabinoids, which could contribute to refilling of energy stores and also to the analgesic and mood-elevating effects of exercise. Circulating concentrations of 2-arachidonoylglycerol are very significantly circadian and dysregulated when sleep is disrupted. Other conditions under which circulating endocannabinoids are altered include inflammation and pain. A second important role for endocannabinoid signaling is to restore homeostasis following stress. Circulating endocannabinoids are stress-responsive and there is evidence that their concentrations are altered in disorders associated with excessive stress, including post-traumatic stress disorder. Although determination of circulating endocannabinoids can provide important information about the state of endocannabinoid signaling and thus allow for hypotheses to be defined and tested, the large number of physiological factors that contribute to their circulating concentrations makes it difficult to use them in isolation as a biomarker for a specific disorder.

show abstract

The Fatty Acid Amide Hydrolase in Lymphocytes from Sedentary and Active Subjects

Abstract: IL-6 leads to activation of the FAAH promoter, thus enhancing FAAH activity that modulates the eCB tone in physically active people.

Cited by 29 publications

References 43 publications

Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament

Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament

Effects of tadalafil administration on plasma markers of exercise-induced muscle damage, IL6 and antioxidant status capacity

Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

Contact Info

Product

Resources

About