The fatigue impact scale for daily use in patients with hepatitis B virus and hepatitis C virus chronic infections

Miranda-Pettersen, Karine; Morais-de-Jesus, Mychelle; Daltro-Oliveira, Renato; Dias, A.; Teles, Carlos; Schinoni, María Isabel; Miranda‐Scippa, Ângela; Paraná, Raymundo

doi:10.1016/s1665-2681(19)31269-4

Cited by 11 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fatigue is the most frequently reported symptom among patients with hepatitis B virus (HBV) in clinical settings and negatively effects on their health outcomes 1 – 3 . Fatigue in liver disease is known as central fatigue.…”

Section: Introductionmentioning

confidence: 99%

A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B

Jang

Kim

Lee

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Fatigue is a major symptom among patients with Hepatitis B virus (HBV). However, the physiological mechanisms regarding mediate fatigue and the relationships between fatigue, cortisol and cytokines are unclear in patients with HBV. The purpose of this study was to examine the relationships between perceived fatigue, cortisol, and cytokines in Korean patients with HBV. The mean score for overall fatigue was moderate. In linear regression analyses, TNF-α was only significant as a predictor of fatigue. In quantile regression analyses, the cortisol level was significant in the 70th, 80th, 90th quantiles in the cognitive/mood fatigue subdimension, which correspond to severe levels of fatigue. IL-6 levels were significant in 90th quantile in overall fatigue and in the cognitive/mood fatigue subdimension. Cortisol, IL-6, and TNF- α were related to perceived fatigue in patients with HBV, particularly in the cognitive/mood dimension. This suggests that the fatigue patterns of patients with HBV are related to their mental and mood states and physical responses, such as cortisol and cytokine levels, are correlated with the nature of the fatigue. In the clinic, interventions to manage fatigue in patients with HBV should be developed based on the characteristics of the fatigue.

show abstract

Section: Introductionmentioning

confidence: 99%

A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B

Jang

Kim

Lee

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Patients with major depression may have unrecognized BD [ 30 ], and depressive symptoms were noted among the course of BD [ 31 ]. On the other hand, evidence showed patients with chronic hepatitis B and C had psychosocially impaired their mental health and daily life [ 32 ]. As a result, those conditions were associated with subsequent occurrence of BD.…”

Section: Resultsmentioning

confidence: 99%

Association of viral hepatitis and bipolar disorder: a nationwide population-based study

et al. 2018

View full text Add to dashboard Cite

BackgroundBipolar disorder (BD), a type of psychiatric mood disorder, is manifested by chronic and recurrent mood fluctuations. This study aims to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for BD.MethodsA total of 48,215 patients with newly diagnosed viral hepatitis from 2000 to 2010 were identified and frequency-matched with 192,860 people without hepatitis. Both groups were followed until diagnosis with BD, withdrawal from the national health insurance program, or the end of 2011. Patients with viral hepatitis were grouped into 3 cohorts: HBV infection, HCV infection, and HBV/HCV coinfection. The association between viral hepatitis and BD were examined using Cox proportional hazards regression models.ResultsThe incidence of BD was higher in HBV/HCV coinfection than in the control group, with an adjusted hazard ratio of 2.16 (95% confidence interval 1.06–4.41) when adjusted for sex, age, and comorbidity. After further adjustment, we noted that an age more than 65 years and female may be associated with an increased risk of BD in patients with chronic hepatitis B and C.ConclusionViral hepatitis may be associated with increased risk of subsequent BD.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1542-3) contains supplementary material, which is available to authorized users.

show abstract

“…However, studies assessing fatigue in patients with CHB are very limited [13, 14]. Furthermore, quantitative evidence is lacking as to what degree this perception is true and what the associated factors are.…”

Section: Introductionmentioning

confidence: 99%

Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction

Wang

Zhou

Yan

et al. 2019

Health Qual Life Outcomes

View full text Add to dashboard Cite

Background Fatigue is an important clinical finding in patients with chronic hepatitis virus infection. However, studies assessing fatigue in patients with chronic hepatitis B (CHB) are very limited. This study aimed to quantify the severity of fatigue in patients with CHB, to determine whether perceived fatigue reflects impairment of functional ability, and to explore potential causes. Methods A total of 133 patients with histologically proven CHB and 59 community controls were assessed using the fatigue impact scale (FIS). Results The degree of fatigue was significantly higher in patients with CHB than in controls (mean (range) FIS 24.9 (0–91) vs. 15.7 (0–31), p < 0.001). Fatigue experienced by patients with CHB was similar to that in primary biliary cirrhosis (PBC) ( n = 20) (FIS 22.2 vs. 20.9, p = 0.28). No association was found between FIS and biochemistry and histological parameters of liver disease severity. Significant associations were found between fatigue severity and cognitive impairment ( r = 0.39, p < 0.001), daytime somnolence ( r = 0.32, p < 0.001), scores of the Chronic Liver Disease Questionnaire ( r = − 0.31, p < 0.001), and autonomic symptoms ( r = 0.43, p < 0.001). The level of autonomic symptom was the only factor independently associated with the degree of fatigue. Conclusion Fatigue is a significant problem of functional ability impairment in CHB and similar in degree to that in PBC patients. Fatigue in patients with CHB appears to be unrelated to the severity of liver disease but is associated with significant autonomic symptoms.

show abstract

The fatigue impact scale for daily use in patients with hepatitis B virus and hepatitis C virus chronic infections

Cited by 11 publications

References 20 publications

A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B

A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B

Association of viral hepatitis and bipolar disorder: a nationwide population-based study

Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction

Contact Info

Product

Resources

About