The effect of corrosion time on the mechanical behavior of 5083/6005A welded joints in a 3.5% NaCl + 0.01 mol/L NaHSO3 solution was evaluated via scanning electron microscopy (SEM), polarization curve analysis, and X-ray photoelectron spectroscopy (XPS). The prediction model of fatigue life after corrosion was established based on the experimental results and the theory of fracture mechanics, and the formula for the effect of corrosion time on lifespan was determined. The results show that with increasing corrosion time, the corrosion of the sample becomes increasingly severe, and the elongation and fatigue life of the 5083/6005A welded joints decrease significantly. The corrosion resistance of the 5083/6005A welded joints decreases with increasing corrosion time because the corrosive medium promotes the destruction of the oxide film and thereby reduces the corrosion resistance. The corrosion products of the 5083/6005A welded joints are Al(OH)3 and AlCl3.