The Fate of the Gallbladder in Patients Admitted to Bariatric Surgery

Kizilkaya, Mehmet; Yılmaz, Serhan

doi:10.4274/haseki.galenos.2021.6716

Cited by 2 publications

(3 citation statements)

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“…To explore possible sources of heterogeneity, meta-regression and subgroup analysis were preformed, even though they did not account for all heterogeneity. The impact of distinct exclusion criteria, mainly in objectives i and ii (risk of de novo post-bariatric GD and its predictive factors), might be an explanation-some authors 18,32,58 excluded patients with preoperative positive findings for GD in ultrasonography, while others 20,23,29 did not, leading to a possible overestimation of GD development.…”

Section: Discussionmentioning

confidence: 99%

“…Seven did not answer, and their studies were excluded from objectives i and ii. In total, 50 articles were included-39 for answering objectives i and ii (assessment of the risk of de novo symptomatic or asymptomatic GD and its predictive factors) 5,7,15,[17][18][19][20][21][22][23][24][26][27][28][29][30][31][32][33][34][35][36][37][39][40][41][42][43][44][45][46]48,49,51,52,55,56,58,62 and 14 for objective iii (comparing BS alone versus BS + prophylactic CCY). 16,25,38,47,[50][51][52][53][54][59]…”

Section: Study Selectionmentioning

confidence: 99%

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Risk and Prophylactic Management of Gallstone Disease in Bariatric Surgery: a Systematic Review and A Bayesian meta-analysis

Amorim-Cruz

Santos‐Sousa

Ribeiro

et al. 2023

Journal of Gastrointestinal Surgery

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Background The frequency and management of gallstone disease (GD) in bariatric patients, including the role of routine prophylactic concomitant cholecystectomy (CCY), are still a matter of debate. This study aims to assess the risk of de novo GD in patients undergoing bariatric surgery (BS) and their predictive factors, as well as mortality and morbidity in prophylactic CCY compared to BS alone. Methods We performed a systematic review, searching PubMed, EMBASE, and Web of Science until April 2021. We performed a Bayesian meta-analysis to estimate the risk of GD development after BS and the morbidity and mortality associated with BS alone versus BS + prophylactic CCY. Sources of heterogeneity were explored by meta-regression analysis. Results The risk of de novo post bariatric GD was 20.7% (95% credible interval [95% CrI] = 13.0–29.7%; I2 = 75.4%), and that of symptomatic GD was 8.2% ([95% CrI] = 5.9–11.1%; I2 = 66.9%). Pre-operative average BMI (OR = 1.04; 95% CrI = 0.92–1.17) and female patients’ proportion (OR = 1.00; 95% CrI = 0.98–1.04) were not associated with increased risk of symptomatic GD. BS + prophylactic CCY was associated with a 97% probability of a higher number of postoperative major complications compared to BS alone (OR = 1.74, 95% CrI = 0.97–3.55; I2 = 56.5%). Mortality was not substantially different between the two approaches (OR = 0.79; 95% CrI = 0.03–3.02; I2 = 20.7%). Conclusion The risk of de novo symptomatic GD after BS is not substantially high. Although mortality is similar between groups, odds of major postoperative complications were higher in patients submitted to BS + prophylactic CCY. It is still arguable if prophylactic CCY is a fitting approach for patients with a preoperative lithiasic gallbladder.

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Section: Discussionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Risk and Prophylactic Management of Gallstone Disease in Bariatric Surgery: a Systematic Review and A Bayesian meta-analysis

Amorim-Cruz

Santos‐Sousa

Ribeiro

et al. 2023

Journal of Gastrointestinal Surgery

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“…This research examined two surgical procedures, RYGB and SG, and defined RYGB as exposure and SG as nonexposure. A total of 10 articles [ 16 – 20 , 23 , 25 , 30 – 32 ] investigated whether the surgical procedure is a risk factor for cholelithiasis after bariatric surgery. There was moderate heterogeneity (I 2 = 66%, P = 0.002), so a random-effect model was used for the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Incidence and risk factors for cholelithiasis after bariatric surgery: a systematic review and meta-analysis

Dai

Luo

2023

Lipids Health Dis

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Background Obesity has been identified as an independent risk factor for cholelithiasis. As a treatment for obesity, bariatric surgery may increase the incidence of cholelithiasis. The risk factors for cholelithiasis after bariatric surgery remain uncertain. The purpose of this study was to explore the risk factors for postoperative cholelithiasis after weight-loss surgery and propose suggestions for clinical decision making. Methods Four databases, PubMed, EMBASE, Web of Science and Cochrane, were systematically searched for all reports about cholelithiasis after bariatric surgery, and literature screening was performed following prespecified inclusion criteria. The included studies were all evaluated for quality according to the NOS scale. Data extraction was followed by analysis using Reviewer Manager 5.4 and StataSE 15. Results A total of 19 articles were included in this meta-analysis, and all studies were of high quality. A total of 20,553 patients were included in this study. Sex [OR = 0.62, 95% CI (0.55, 0.71), P < 0.00001] and race [OR = 1.62, 95% CI (1.19, 2.19), P = 0.002] were risk factors for cholelithiasis after bariatric surgery. Surgical procedure, preoperative BMI, weight-loss ratio, smoking, hypertension, diabetes mellitus, and dyslipidemia were neither protective nor risk factors for cholelithiasis after bariatric surgery. Conclusion Caucasian race and female sex are risk factors for developing cholelithiasis after bariatric surgery; surgical procedure, BMI, weight loss ratio, hypertension, diabetes mellitus, dyslipidemia, and smoking are not risk factors for cholelithiasis after bariatric surgery.

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The Fate of the Gallbladder in Patients Admitted to Bariatric Surgery

Cited by 2 publications

References 0 publications

Risk and Prophylactic Management of Gallstone Disease in Bariatric Surgery: a Systematic Review and A Bayesian meta-analysis

Risk and Prophylactic Management of Gallstone Disease in Bariatric Surgery: a Systematic Review and A Bayesian meta-analysis

Incidence and risk factors for cholelithiasis after bariatric surgery: a systematic review and meta-analysis

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