The fate of platinum(II) and platinum(IV) anti-cancer agents in cancer cells and tumours

Hall, Matthew D.; Alderden, Rebecca A.; Zhang, Mei; Beale, Philip; Cai, Zhonghou; Lai, Barry; Stampfl, A. P. J.; Hambley, Trevor W.

doi:10.1016/j.jsb.2006.01.011

Cited by 86 publications

(79 citation statements)

References 9 publications

(7 reference statements)

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“…[26] The second approach is to perform the experiment at a higher energy (13.6 keV) that includes the Pt L  peaks in the emitted X-rays and use these to estimate the Pt concentration. [38] Microprobe SRXRF studies of cisplatin-treated A2780 ovarian carcinoma cells revealed predominant localisation of Pt in the nucleus with a small amount in the cytoplasm following 24 h exposure. [33] The uptake of Pt(II) and Pt(IV) potential anti-cancer agents by the A2780 cells with the metallointercalator, cis-[PtCl 2 (2-[(3-aminopropyl)amino]-9,10-anthracenedione)(NH 3 )], revealed a high colocalisation of Pt and P maps which was attributed to Pt localisation in the cell nucleus.…”

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

“…[26,38] One of the most studied class of drugs includes the platinum-containing drugs. This is unsurprising due to the therapeutic significance of cisplatin, carboplatin and oxaliplatin which are used in the treatment regimes of more than half of all cancer patients receiving chemotherapy.…”

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

“…This is unsurprising due to the therapeutic significance of cisplatin, carboplatin and oxaliplatin which are used in the treatment regimes of more than half of all cancer patients receiving chemotherapy. [38][39] Since the Pt L  peaks (Pt L 1 = 9.44 keV, Pt L 2 = 9.361 keV) coexist with that of the Zn K  peak (Zn K 1 = 9.572 keV), there are two approaches to the analysis of Pt in biological samples. [26,38] The first is the estimation of the Zn K  contribution to the Pt L  based on the known ratio of the Zn K  peaks to the Zn K  peak, followed by the subtraction of this value from the Pt L  peaks.…”

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

“…[38][39] Since the Pt L  peaks (Pt L 1 = 9.44 keV, Pt L 2 = 9.361 keV) coexist with that of the Zn K  peak (Zn K 1 = 9.572 keV), there are two approaches to the analysis of Pt in biological samples. [26,38] The first is the estimation of the Zn K  contribution to the Pt L  based on the known ratio of the Zn K  peaks to the Zn K  peak, followed by the subtraction of this value from the Pt L  peaks. [26] The second approach is to perform the experiment at a higher energy (13.6 keV) that includes the Pt L  peaks in the emitted X-rays and use these to estimate the Pt concentration.…”

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

“…[33] The uptake of Pt(II) and Pt(IV) potential anti-cancer agents by the A2780 cells with the metallointercalator, cis-[PtCl 2 (2-[(3-aminopropyl)amino]-9,10-anthracenedione)(NH 3 )], revealed a high colocalisation of Pt and P maps which was attributed to Pt localisation in the cell nucleus. [38] A study of Br-labeled Pt(II) and Pt(IV)-treated cells was performed to probe the mechanisms of Pt anti-cancer activity. In the first instance, one of the amine ligands of cisplatin was substituted with a 3-bromopyridine ligand.…”

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

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Synchrotron Radiation Spectroscopic Techniques as Tools for the Medicinal Chemist: Microprobe X-Ray Fluorescence Imaging, X-Ray Absorption Spectroscopy, and Infrared Microspectroscopy

Dillon

2012

Aust. J. Chem.

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. (2012). Synchrotron radiation spectroscopic techniques as tools for the medicinal chemist: microprobe X-Ray fluorescence imaging, X-Ray absorption spectroscopy, and infrared microspectroscopy. Australian Journal of Chemistry: an international journal for chemical science, 65 (3), 204-217. Synchrotron radiation spectroscopic techniques as tools for the medicinal chemist: microprobe X-Ray fluorescence imaging, X-Ray absorption spectroscopy, and infrared microspectroscopy AbstractThis review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescence spectroscopy/imaging, X-ray absorption spectroscopy, and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist. A brief description of the principles of the techniques is given with emphasis on the advantages of using synchrotron radiation-based instrumentation rather than instruments using typical laboratory radiation sources. This review focuses on several recent applications of these techniques to solve inorganic medicinal chemistry problems, focusing on studies of cellular uptake, distribution, and biotransformation of established and potential therapeutic agents. The importance of using these synchrotron-based techniques to assist the development of, or validate the chemistry behind, drug design is discussed. AbstractThis review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescent spectroscopy/imaging, X-ray absorption spectroscopy and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist. A brief description of the principles of the techniques is given with emphasis on the advantages of using synchrotron radiation-based instrumentation rather than instruments using typical laboratory radiation sources. This review focuses on a number of recent applications of these techniques to solve inorganic medicinal chemistry problems, focusing on studies of cellular uptake, distribution and biotransformation of established and potential therapeutic agents. The importance of using these synchrotron-based techniques to assist the development, or validate the chemistry behind, drug design is discussed.3

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Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

Section: Platinum-containing Anti-cancer Agentsmentioning

confidence: 99%

See 3 more Smart Citations

Synchrotron Radiation Spectroscopic Techniques as Tools for the Medicinal Chemist: Microprobe X-Ray Fluorescence Imaging, X-Ray Absorption Spectroscopy, and Infrared Microspectroscopy

Dillon

2012

Aust. J. Chem.

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Platinum Anticancer Drugs, Chemical Biology of

Zhang

Whan

Hambley

2008

Wiley Encyclopedia of Chemical Biology

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In the past, studies into the distribution of platinum anti‐cancer agents inside cancer cells were experimentally challenging because of a lack of readily available and sensitive platinum mapping techniques. Recent advancements in the area of platinum mapping in cells have meant that the biologic fate of cisplatin and its derivatives can be studied in several new ways. In particular, electron microscopy, fluorescence microscopy, and synchrotron radiation induced X‐ray emission have made significant contributions in the study of cisplatin in vitro . The applications of these three techniques and the insights they provide into the intracellular distributions and interactions platinum complexes are reviewed here. The strengths and weaknesses of each technique and their potentials for additional use in this field of research have been evaluated.

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Platinum‐Based Anticancer Agents

Klein

Hambley

2014

Ligand Design in Medicinal Inorganic Chemistry

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The fate of platinum(II) and platinum(IV) anti-cancer agents in cancer cells and tumours

Cited by 86 publications

References 9 publications

Synchrotron Radiation Spectroscopic Techniques as Tools for the Medicinal Chemist: Microprobe X-Ray Fluorescence Imaging, X-Ray Absorption Spectroscopy, and Infrared Microspectroscopy

Synchrotron Radiation Spectroscopic Techniques as Tools for the Medicinal Chemist: Microprobe X-Ray Fluorescence Imaging, X-Ray Absorption Spectroscopy, and Infrared Microspectroscopy

Platinum Anticancer Drugs, Chemical Biology of

Platinum‐Based Anticancer Agents

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