The Fate of Meniscus Cartilage After Transplantation of Cryopreserved Nontissue-Antigen-Matched Allograft A Case Report

Hh, de Boer; Koudstaal, J

doi:10.1097/00003086-199105000-00023

Cited by 41 publications

(21 citation statements)

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“…Biological factors include the ability (a) to be accepted with minimum immunological response, (b) following preservation, to repopulate with host cells that restore normal synthetic activity, and (c) to heal to surrounding tissue (9,20,22). In animal studies (2.9) and clinical follow-up studies on human patients (5,7,17,20), meniscal allografts have shown the potential to meet these biological criteria. However, incomplete peripheral healing and shrinkage have been observed (11,12,20).…”

Section: Interpretation Of Resultsmentioning

confidence: 99%

Use of roentgenography and magnetic resonance imaging to predict meniscal geometry determined with a three‐dimensional coordinate digitizing system

Haut

Hull

Howell

2000

Journal Orthopaedic Research

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To evaluate and improve on the procedures used by a tissue bank in selecting donor menisci for transplantation, this study was designed to fulfill four objectives: (a) define and quantify a set of independent parameters for describing the geometry of the medial and lateral menisci, (b) determine how well the sizing protocol of the tissue bank (i.e., two transverse roentgenographic measurements obtained from the injured knee or six transverse magnetic resonance imaging measurements obtained from the contralateral knee) predicts the four standard transverse parameters of the menisci, (c) determine if including one additional transverse roentgenographic measurement for each compartment improves the ability of roentgenograms to predict transverse meniscal parameters, and (d) determine if five magnetic resonance imaging measurements at three different meniscal cross sections of the contralateral knee predict the 15 standard cross-sectional parameters of the meniscus in the injured knee. A laser-based, noncontacting three-dimensional coordinate digitizing system was used to determine surface coordinates from which menisci were reconstructed in a computer. For each reconstructed meniscus, four parameters in the transverse plane and five cross-sectional parameters in each of three regions (i.e., anterior, middle, and posterior) were defined, yielding a set of 19 standard parameters to describe the geometry. Through a correlation analysis, these standard parameters were shown to be largely unrelated to one another, thus confirming that the parameters form an independent set describing the three-dimensional geometry of the menisci. The two roentgenographic measurements were poor predictors of transverse standard meniscal parameters, predicting only one of four standard parameters for the medial meniscus and none of four standard parameters for the lateral meniscus with coefficients of determination greater than or equal to 0.5. Including one additional roentgenographic measurement to the tissue bank protocol increased the number of standard transverse parameters predicted to three of four for the medial meniscus and two of four for the lateral meniscus. Magnetic resonance imaging was better than roentgenography for predicting the three-dimensional meniscal geometry. The transverse measurements from magnetic resonance imaging predicted three of four standard transverse parameters for the medial meniscus and all four for the lateral meniscus. With the addition of the cross-sectional measurements by magnetic resonance imaging, seven of 15 standard cross-sectional parameters were predicted for both the medial and lateral menisci. Assuming that a successful clinical outcome depends on how well an allograft matches the size and shape of the original meniscus, magnetic resonance imaging rather than roentgenography should be used for allograft size-matching by tissue banks.

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Section: Interpretation Of Resultsmentioning

confidence: 99%

Use of roentgenography and magnetic resonance imaging to predict meniscal geometry determined with a three‐dimensional coordinate digitizing system

Haut

Hull

Howell

2000

Journal Orthopaedic Research

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“…Neither lymphocytes nor histiocytes were found in the meniscal fibrocartilage. In the parts of those menisci which were still attached to the capsule, there was vascular ingrowth with vital cells in the vicinity (de Boer and Koudstaal 1994). Cell proliferation was evaluated in the three removed meniscal atlografts.…”

Section: Resultsmentioning

confidence: 99%

“…The Ki-67 antigen and the PCNA are both expressed in all the phases of mitosis except Go and early Gi (the resting phase of the cell cycle), but not in quiescent cells (Dervan et al 1992). The growth potential of the graft as shown by the proliferation markers Ki-67 and PCNA seemed to be practically nil (de Boer and Koudstaal 1994).…”

Section: Discussionmentioning

confidence: 97%

Human meniscal transplantation. Preliminary results at 2 to 5-year follow-up

Arkel

Boer²

1995

The Journal of Bone and Joint Surgery. British volume

207

136

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“…While abnormal remodeling and allograft failure have been attributed to improper sizing, positioning, and mechanical fixation [7,10,2 1,25,28,35,37], methods to chemically stabilize the tissue to preserve its properties have received little attention. This is surprising given that methods like deep freezing and cryopreservation do not deter degradation by matrix metalloproteinases, a possible cause of allograft failure [9,15]. However, even these stabilization methods must not alter initial meniscal material properties and normal function.…”

Section: Introductionmentioning

confidence: 99%

Meniscal material properties are minimally affected by matrix stabilization using glutaraldehyde and glycation with ribose

Hunter¹,

Noyes²,

Haridas³

et al. 2005

J. Orthop. Res.

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Knee meniscus replacement holds promise, but current allografts are susceptible to biodegradation. Matrix stabilization with glutaraldehyde, a crosslinking agent used clinically to fabricate cardiovascular bioprostheses, or with glycation, a process of crosslinking collagen with sugars such as ribose, is a potential means of rendering tissue resistant to such degradation. However, stabilization should not significantly alter meniscal material properties, which could disturb normal function in the knee. Our objective was to evaluate the effects of glutaraldehyde-and glycation-induced matrix stabilization on the material properties of porcine meniscus.Normal untreated meniscus specimens were tested in confined compression at one of three applied stresses (0.069, 0.208, 0.347 MPa), subjected to either a glutaraldehyde or glycation stabilization treatment, and then re-tested to measure changes in tissue aggregate modulus, permeability, and compressive strain at equilibrium. Changes in these properties significantly increased with glutaraldehyde concentration and exposure time to ribose. One glutaraldehyde and three glycation treatments did not alter aggregate modulus or compressive strain at equilibrium compared to controls (p > 0.10). However, all treatments increased permeability by at least 108% compared to controls (p < 0.001). This study reveals a dose-dependent relationship between meniscal material properties and certain stabilization conditions and identifies treatments that minimally affect these properties. Further research is necessary to determine whether these treatments prevent enzymatic degradation before and after surgical implantation in the knee.

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The Fate of Meniscus Cartilage After Transplantation of Cryopreserved Nontissue-Antigen-Matched Allograft A Case Report

Cited by 41 publications

References 0 publications

Use of roentgenography and magnetic resonance imaging to predict meniscal geometry determined with a three‐dimensional coordinate digitizing system

Use of roentgenography and magnetic resonance imaging to predict meniscal geometry determined with a three‐dimensional coordinate digitizing system

Human meniscal transplantation. Preliminary results at 2 to 5-year follow-up

Meniscal material properties are minimally affected by matrix stabilization using glutaraldehyde and glycation with ribose

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