The fate of intracardially administered retinyl esters in the rat

Influence of etretinate on blood and liver in rats.

“…Mahadevan et al have reported the accumulation of natural re tinoids as the test results with various retinyl esters and retinol. According to them, the administered retinoids accumulated in the liver eventually as retinyl palmitate, and the liver level of retinyl palmitate was higher at 24 hr post-dose than immediately after admin istration even in the group receiving retinyl palmitate (2).…”

“…Also, it has been reported that hypervitami nosis A induced by treatment with various retinoids is considered to be due to their tendency to accumulate in the liver. Such retinoids are finally stored in the liver in the form of retinyl palmitate (2). On the other hand, etretinate is effective for many kinds of dermal diseases and less toxic than natural retinoids.…”