The fate of <i>Pseudomonas aeruginosa, Proteus mirabilis</i> and <i>Escherichia coli</i> in the mouse kidney

Gorrill, R. H.

doi:10.1002/path.1700890110

Cited by 14 publications

(13 citation statements)

References 4 publications

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“…Other mechanisms such as growth stimulation of B. fragilis by E. coli as suggested by Hagen et al (1982) may also be involved. The fate of the bacteria during the first 24 h of the experiments has been shown to be crucial for the outcome of infection (Miles et al 1957;Gorrill, 1965). Our model shows that in the presence of B. fragilis the clearance of E. coli from the skin of mice was reduced and multiplication occurred in vivo.…”

Section: Discussionmentioning

confidence: 64%

Pathogenic synergy between Escherichia coli and Bacteroides fragilis: studies in an experimental mouse model

Vught

Namavar

Sparrius

et al. 1985

Journal of Medical Microbiology

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Section: Discussionmentioning

confidence: 64%

Pathogenic synergy between Escherichia coli and Bacteroides fragilis: studies in an experimental mouse model

Vught

Namavar

Sparrius

et al. 1985

Journal of Medical Microbiology

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“…Protelus miirabilis is the primary urease-producing uropathogen in humans (197). The role of Protelus urease in pyelonephritis was studied by Braude and Siemienski (20) by using both a rat model and a tissue culture system and by MacLaren (131), Gorrill (67), and Fitzpatrick (55) (20). In the mouse model, an ethyl methanesulfonate-generated urease-negative mutant of Proteuis mirabilis produced much smaller renal abscesses than the parent strain and lower populations in the kidney (131).…”

Section: Role Of Urease In Pathogenesismentioning

confidence: 99%

Microbial ureases: significance, regulation, and molecular characterization.

Mobley¹,

Hausinger²

1989

Microbiological Reviews

845

538

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“…Thus, we decided to measure the kinetics of the viable count in the mouse kidney after intravenous (i.v.) injection (10,11,23).…”

mentioning

confidence: 99%

Virulence of Escherichia coli in experimental hematogenous pyelonephritis in mice

Bosch¹,

Graaff²,

Maclaren³

1979

Infect Immun

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Differences in nephropathogenicity between Escherichia coli strains were studied by following the kinetics of the viable count in the mouse kidney during 8 h after intravenous injection. Assuming as a reference point that at zero time 0.1% of the inoculum was lodged in the kidney, we found that strains fell into three main groups with different behavior patterns: in group I, the viable count fell and remained low; in group II, the viable count first fell and then rose after 4 h, reaching the level of the reference point within 8 h; in group III, the viable count rose rapidly and remained high. The kinetics of the viable counts were also studied in blood, spleen, and liver: group I and II strains behaved similarly; only in the kidney did group II strains show higher counts than group I strains. These data suggest that group II strains are specifically virulent for the mouse kidney. Group III strains also gave higher viable counts in blood and spleen but comparable counts in the liver, suggesting that group III strains are more generally virulent. Fifty percent lethal dose measurements confirmed the conclusion that group I strains are avirulent and group III strains are the most virulent. Possible relationships between behavior pattern and serotype are discussed.

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The fate of Pseudomonas aeruginosa, Proteus mirabilis and Escherichia coli in the mouse kidney

Cited by 14 publications

References 4 publications

Pathogenic synergy between Escherichia coli and Bacteroides fragilis: studies in an experimental mouse model

Pathogenic synergy between Escherichia coli and Bacteroides fragilis: studies in an experimental mouse model

Microbial ureases: significance, regulation, and molecular characterization.

Virulence of Escherichia coli in experimental hematogenous pyelonephritis in mice

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