1995
DOI: 10.1016/0161-5890(95)00004-x
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The fate of human CD77+ germinal center B lymphocytes after rescue from apoptosis

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Cited by 27 publications
(17 citation statements)
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“…The observed rapid death of CD77 ϩ germinal center B cells in vitro suggests that endogenous ligand molecules interact with Gb3/CD77 to bring about the physiologic selection of immature B cells (12,35). Furthermore, the capability of the B subunit of VT to induce apoptosis of Gb3/CD77 ϩ cells (18) strongly encourages the investigation of Gb3/CD77-associating cytoplasmic molecules (34).…”
Section: Discussionmentioning
confidence: 99%
“…The observed rapid death of CD77 ϩ germinal center B cells in vitro suggests that endogenous ligand molecules interact with Gb3/CD77 to bring about the physiologic selection of immature B cells (12,35). Furthermore, the capability of the B subunit of VT to induce apoptosis of Gb3/CD77 ϩ cells (18) strongly encourages the investigation of Gb3/CD77-associating cytoplasmic molecules (34).…”
Section: Discussionmentioning
confidence: 99%
“…Refinements of these techniques, particularly those using CD40 monoclonal antibody or CD40-ligand bound to fibroblasts (82,83), have produced impressive systems for long-term culture of germinal centre B cells, but critical evaluation of these methods shows that they fail to generate cells that have the phenotype of normal memory cells. Cells that have some features of memory cells are only produced after several days in culture (83,84). far longer than the 24 hours required to generate memory ceils from germinal centre B cells in vivo.…”
Section: Selection Of Centrocytes and Tbeir Differentiationmentioning
confidence: 99%
“…Evidence for a relationship between globotriaosylceramide expression and apoptosis in B lymphocytes (Mangeney et al, 1995) and Burkitt lymphoma cells (Mangeney et al, 1993) has been provided. More recently, it has been shown that apoptosis induced in HuT78 human lymphoma cells by Fas ligation or short-chain ceramide administration is mediated by GD3 ganglioside synthesis and can be prevented by GluCer synthase inhibition (De Maria et al, 1997).…”
Section: Discussionmentioning
confidence: 99%