The Fate of Free Grafts in the Common Bile Duct*

Myers, Richard T.; Meredith, Jesse H.; Rhodes, James; Gilbert, Joseph W.

doi:10.1097/00000658-196005000-00018

Cited by 47 publications

(7 citation statements)

References 5 publications

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“…[5][6][7][8][9][10] Other surgical approaches using various autologous conduits such as jejunum, artery, vein, split-thickness skin grafts, fascia, bile duct homografts, ureter, and appendix have also failed mostly because of cicatrisation and recurrent stricture formation. [11][12][13][14][15][16][17][18][19]…”

mentioning

confidence: 99%

Small intestinal submucosa as a bioscaffold for biliary tract regeneration

Rosen

Ponsky

Petras

et al. 2002

Surgery

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mentioning

confidence: 99%

Small intestinal submucosa as a bioscaffold for biliary tract regeneration

Rosen

Ponsky

Petras

et al. 2002

Surgery

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“…The search for a suitable substitute to repair a long common bile duct defect caused by disease or trauma has attracted many researchers[9]. A wide variety of autografts ( e.g ., artery, vein, ureter, appendix, jejunum) and synthetic grafts ( e.g ., Vitallium, polyvinyl sponge, polytetrafluoroethylene, Teflon, Dacron) have been introduced as substitutes to repair common bile duct defects in situ [8-11,17-22].…”

Section: Discussionmentioning

confidence: 99%

Repair of a common bile duct defect with a decellularized ureteral graft

Cheng¹,

Xiong²,

Zhou³

et al. 2016

WJG

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AIMTo evaluate the feasibility of repairing a common bile duct defect with a decellularized ureteral graft in a porcine model.METHODSEighteen pigs were randomly divided into three groups. An approximately 1 cm segment of the common bile duct was excised from all the pigs. The defect was repaired using a 2 cm long decellularized ureteral graft over a T-tube (T-tube group, n = 6) or a silicone stent (stent group, n = 6). Six pigs underwent bile duct reconstruction with a graft alone (stentless group). The surviving animals were euthanized at 3 mo. Specimens of the common bile ducts were obtained for histological analysis.RESULTSThe animals in the T-tube and stent groups survived until sacrifice. The blood test results were normal in both groups. The histology results showed a biliary epithelial layer covering the neo-bile duct. In contrast, all the animals in the stentless group died due to biliary peritonitis and cholangitis within two months post-surgery. Neither biliary epithelial cells nor accessory glands were observed at the graft sites in the stentless group.CONCLUSIONRepair of a common bile duct defect with a decellularized ureteral graft appears to be feasible. A T-tube or intraluminal stent was necessary to reduce postoperative complications.

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“…The literature search enabled the classification of BDSs into four categories: Autologous tissues[ 10 , 15 - 18 ], non-bioabsorbable materials[ 19 - 23 ], bioabsorbable materials[ 24 - 28 ], and others (decellularized tissues[ 29 , 30 ], structures made with 3D printers[ 41 , 42 ], etc. ).…”

Section: Bds Reported To Datementioning

confidence: 99%

“…Therefore, the development of BDS has emerged as a critical, unmet need. To date, various alternatives, including autologous tissue[ 10 , 15 - 18 ], non-bioabsorbable[ 19 - 23 ], bioabsorbable materials[ 24 - 28 ], and decellularized tissue[ 29 , 30 ], have been investigated. Nevertheless, BDSs with widespread clinical applications have not yet been developed.…”

Section: Introductionmentioning

confidence: 99%

Pitfalls and promises of bile duct alternatives: A narrative review

Miyazawa¹,

Aikawa²,

Takashima³

et al. 2022

World J Gastroenterol

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Biliodigestive anastomosis between the extrahepatic bile duct and the intestine for bile duct disease is a gastrointestinal reconstruction that abolishes duodenal papilla function and frequently causes retrograde cholangitis. This chronic inflammation can cause liver dysfunction, liver abscess, and even bile duct cancer. Although research has been conducted for over 100 years to directly repair bile duct defects with alternatives, no bile duct substitute (BDS) has been developed. This narrative review confirms our understanding of why bile duct alternatives have not been developed and explains the clinical applicability of BDSs in the near future. We searched the PubMed electronic database to identify studies conducted to develop BDSs until December 2021 and identified studies in English. Two independent reviewers reviewed studies on large animals with 8 or more cases. Four types of BDSs prevail: Autologous tissue, non-bioabsorbable material, bioabsorbable material, and others (decellularized tissue, 3D-printed structures, etc. ). In most studies, BDSs failed due to obstruction of the lumen or stenosis of the anastomosis with the native bile duct. BDS has not been developed primarily because control of bile duct wound healing and regeneration has not been elucidated. A BDS expected to be clinically applied in the near future incorporates a bioabsorbable material that allows for regeneration of the bile duct outside the BDS.

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The Fate of Free Grafts in the Common Bile Duct*

Cited by 47 publications

References 5 publications

Small intestinal submucosa as a bioscaffold for biliary tract regeneration

Small intestinal submucosa as a bioscaffold for biliary tract regeneration

Repair of a common bile duct defect with a decellularized ureteral graft

Pitfalls and promises of bile duct alternatives: A narrative review

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