The Fate of Creatine When Administered to Man

Chanutin, Alfred; Guy, Loren P.

doi:10.1016/s0021-9258(18)84727-5

Cited by 92 publications

(3 citation statements)

References 6 publications

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“…Creatine is a natural compound that plays a critical role in supplying cellular energy and intracellular energy in combination with creatine kinase. It is produced endogenously and is found exogenously in various dietary sources, including meats and fish [75]. Recent data suggest that creatine supplementation has a variety of positive effects on various cellular functions that are not energy-related.…”

Section: Creatine Supplementationmentioning

confidence: 99%

Cardiac Oxidative Stress and the Therapeutic Approaches to the Intake of Antioxidant Supplements and Physical Activity

2021

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Reactive oxygen species (ROS) are strongly reactive chemical entities that include oxygen regulated by enzymatic and non-enzymatic antioxidant defense mechanisms. ROS contribute significantly to cell homeostasis in the heart by regulating cell proliferation, differentiation, and excitation-contraction coupling. When ROS generation surpasses the ability of the antioxidant defense mechanisms to buffer them, oxidative stress develops, resulting in cellular and molecular disorders and eventually in heart failure. Oxidative stress is a critical factor in developing hypoxia- and ischemia-reperfusion-related cardiovascular disorders. This article aimed to discuss the role of oxidative stress in the pathophysiology of cardiac diseases such as hypertension and endothelial dysfunction. This review focuses on the various clinical events and oxidative stress associated with cardiovascular pathophysiology, highlighting the benefits of new experimental treatments such as creatine supplementation, omega-3 fatty acids, microRNAs, and antioxidant supplements in addition to physical exercise

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Section: Creatine Supplementationmentioning

confidence: 99%

Cardiac Oxidative Stress and the Therapeutic Approaches to the Intake of Antioxidant Supplements and Physical Activity

2021

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“…We must admit in 2024 that we don’t know why such differences are observed. One could also evoke the difference of diet (notably the difference in meat consumption which is known to influence serum creatinine [47‒50]), but this hypothesis is also purely speculative. The second question is about the definition of a “population.” It would be very questionable to define a population only based on race or skin color.…”

Section: What Glomerular Filtration Rate Estimation Is (And What It I...mentioning

confidence: 99%

“…We have largely commented on the problems with serum creatinine as a renal biomarker due to non-GFR determinants and the impact of diet [47][48][49][50]. However, there is one other important limitation we want to briefly comment on.…”

mentioning

confidence: 99%

Glomerular Filtration Rate Estimation in Adults: Myths and Promises

Delanaye,

Cavalier,

Stehlé

et al. 2024

Nephron

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Background: In daily practice, glomerular filtration rate (GFR) is estimated with equations including renal biomarkers. Among these biomarkers, serum creatinine remains the most used. However, there are many limitations with serum creatinine we will discuss in the current review. We will also discuss how creatinine-based equations have been developed and what we can expect from them in terms of performance to estimate GFR. Summary: Different creatinine-based equations have been proposed. We will show the advantages of the recent European Kidney Function Consortium (EKFC) equation. This equation can be used in children and adults. This equation can also be used with some flexibility in different populations. Key messages: GFR is estimated by creatinine-based equations, but the most important for nephrologists is probably to know the limitations of these equations.

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