The fate of 5-hydroxy-N-acetyltryptophan and 5-acetoxy-N-acetyltryptophan in the rat organism

Erspamer, V.; Glässer, A.; Nobili, Mauro

doi:10.1016/s0003-9861(61)80069-6

Cited by 7 publications

(4 citation statements)

References 1 publication

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“…5-Hydroxy-Nacetyl-TP and 5-acetoxy-N-acetyl-TP have been decarboxylated only after their hydrolytic conversion to 5-HTP. No acetylated tryptamines could be detected in the urine of rats given the two aminoacids [385].…”

Section: Decarboxylation Of 5-ht Pmentioning

confidence: 86%

“…With 5-hydroxy-N-acetyl-TP and 5-acetoxy-N-acetyl-TP no significant rise in brain 5-HT levels could be demonstrated, although the formation of small amounts of the amine from the precursor aminoacids is highly probable [385].…”

Section: Biochemical and Pharmacological Effects Of 5-htp And Relatedmentioning

confidence: 87%

“…This demonstrates that only 5-HT reaching the kidney via the blood is capable of reducing urine flow, whereas the amine generated within the kidney by decarboxylation of 5-HTP is inactive [385].…”

Section: Action On the Circulation And The Function Of The Kidneymentioning

confidence: 96%

“…Following administration of L-tryptophan, 5-0H-N-acetyITP, 5-acetoxy-N-acetylTP and 4-HTP, the urinary excretion of the corresponding amines is less than 0·02% [574, 868b], 4-6%, 4% and 8-20%, respectively, as referred to the L-aminoacid [381,385].…”

Section: Urinary Excretionmentioning

confidence: 99%

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