The fate of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) following oral administration to rats and dogs

The Toxicology, Environmental Fate, and Human Risk of Herbicide Orange and Its Associated Dioxin

“…The volume of distribution after a single oral dose of 5 mg/kg also differed: in man, 0.079; in rats, 0.14; and in dogs, 0.22 1/kg (49,104).…”

“…When the dose of 2,4,5-T to rats was increased to 200 mg/kg the biological half-life was prolonged to 25 h, indicating that the excretory capacity of the animals could be exceeded (104 …”

Conditioned taste aversion induced by 2,4,5-trichlorophenoxyacetic acid: Dose-response and preexposure effects

“…(2) It is likely that the threshold doses of 2,4,5-T for producing taste aversion may vary between species of animals. Dogs, for instance, have been shown to have a much slower rate of elimination of 2,4,5-T than do rats (Piper, Rose, Leng, & Gehring, 1973). Thus, the empirically determined values in the present study may not be directly generalizable to the field application of 2,4,5-T. Further studies with different speqes under analogous field conditions are therefore necessary.…”

Renal handling of 2‐methyl‐4‐chlorophenoxyacetic acid (MCPA) in rats

“…In accordance with our data, the extent of binding of other chlorophenoxyacetic acid derivatives reaches 70 and 90%. [19][20][21]22 This binding of MCPA to plasma albumin excluded a distinct involvement of glomerular filtration ia renal excretion of MCPA. We have not measured whether or not bound MCPA can be filtered glomerularly together with albumin.…”