The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat

Rose, James Q.; Ramsey, John C.; Wentzler, T.H.; Hummel, Richard A.; Gehring, P.J.

doi:10.1016/0041-008x(76)90001-6

Cited by 294 publications

(65 citation statements)

References 10 publications

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“…Thus, the rate at which the liver level of TCDD is decreased should show a similar difference among species. Data obtained in this study shows that the time taken to regain the ability to increase the liver vitamin A (Tables 2-6) correlates reasonably well with literature data on the elimination rate for TCDD (5, [23][24][25][26][27][28][29]. Whether the hepatic level of TCDD, at the time of the resumed ability to store vitamin A, is similarly low in all species or is species specific remains to be elucidated.…”

Section: Golden Syrian Hamsterssupporting

confidence: 75%

“…Half-lives for whole-body elimination of TODD, obtained in studies where rela tively low single doses have been given, show that the elimination rate is faster in mice (23,24) and hamsters (25), as compared to more susceptible species such as rats (5, [26][27][28] and guinea pigs (29). In the case of TCDD there is good correlation between the whole-body and liver half-lives in various species (24,26,28). Thus, the rate at which the liver level of TCDD is decreased should show a similar difference among species.…”

Section: Golden Syrian Hamstersmentioning

confidence: 99%

See 1 more Smart Citation

Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD) on the Vitamin A Status of Hartley Guinea Pigs, Sprague-Dawley Rats, C57B1/6 Mice, DBA/2 Mice, and Golden Syrian Hamsters.

Håkansson

Johansson

Manzoor

et al. 1991

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Section: Golden Syrian Hamsterssupporting

confidence: 75%

Section: Golden Syrian Hamstersmentioning

confidence: 99%

Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD) on the Vitamin A Status of Hartley Guinea Pigs, Sprague-Dawley Rats, C57B1/6 Mice, DBA/2 Mice, and Golden Syrian Hamsters.

Håkansson

Johansson

Manzoor

et al. 1991

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Our observation that the levels of 14C-activity in both cell types were highest 3-5 days after treatment (Fig. 5) is consistent with the results of an earlier pharmacokinetic study (21). The elevated levels of 14C-activity observed in the isolated cells may, in part, be a reflection of the enterohepatic circulation of TCDD or a more polar metabolite.…”

Section: Cell-specific Enzyme Inductionsupporting

confidence: 81%

Chemical exposure and intestinal function.

Schiller¹

1979

Environ Health Perspect

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The particular substances that are ingested by individuals are the consequence of their environmental, residential, and occupational exposures. The possible effects of these exposures on intestinal functions can beexamined by the evaluation ofin vivo orin vitro exposure followed by an in vivo and/or in vitro monitoring of effects. Several examples of the in vivo exposure and in vitro monitoring approach are presented to demonstrate the consequences oforal exposure to either a heavy metal (arsenic), or a herbicide contaminant (2,3,7,8-tetrachlorodibenzo-p-dioxin) or a jet fuel propellant (hydrazine) and the subsequent measurement of either a particular metabolic pathway, or a cell-specific enzyme induction or the development of brush border enzymes are presented.

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“…The differences in elimination rate constants between PCDFs and PCDDs were also observed in rats. Rose et al (1976) and determined the half lives of 2,3,7,8-TCDD and 2,3,7,8-TCDF in rats as 31 and 1 days, respectively.…”

Section: Accumulation Kineticsmentioning

confidence: 99%

Bioconcentration of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in guppies after aqueous exposure to a complex PCDD/PCDF mixture: relationship with molecular structure

et al. 1994

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Bioconcentration of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in guppies after aqueous exposure to a complex PCDD/PCDF mixture: relationship with molecular structure. Loonen, H.E.W.M.; Tonkes, M.; Parsons, J.R.; Govers, H.A.J. Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. AbstractGuppies (Poecilia reticulata) were exposed to a complex mixture of polychlorinated dibenzop-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in water for 21 days. It is the first study in which accumulation data of 15 toxic dioxins and furans were quantified simultaneously in a continuous exposure experiment. First-order uptake rate constants (kl) and firstorder elimination rate constants (k2) were calculated for the toxic, laterally substituted congeners. Bioconcentration factors (BCFs) were calculated from both the ratios of concentrations in fish and water and from the ratios of the rate constants. Dioxins and furans were selectively accumulated in fish tissue. The non-laterally substituted congeners were either not observed in fish tissue or showed lower BCF values than their laterally 2,3,7,8-substituted isomers. The log BCF values of laterally substituted congeners ranged from 3.90 + 0.06 to 5.27 + 0.07. BCF values were smaller than predicted by existing linear relationships with log Kow. Several phenomena were discussed with respect to the observed bioconcentration behaviour, such as limited bioavailability, reduced lipid solubility, reduced membrane permeability and biotransformation. Furthermore, the similarity between structure-activity relationships considering bioaccumulation in fishes and the Ah-affinity in mammals was discussed.

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The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat

Cited by 294 publications

References 10 publications

Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD) on the Vitamin A Status of Hartley Guinea Pigs, Sprague-Dawley Rats, C57B1/6 Mice, DBA/2 Mice, and Golden Syrian Hamsters.

Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD) on the Vitamin A Status of Hartley Guinea Pigs, Sprague-Dawley Rats, C57B1/6 Mice, DBA/2 Mice, and Golden Syrian Hamsters.

Chemical exposure and intestinal function.

Bioconcentration of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in guppies after aqueous exposure to a complex PCDD/PCDF mixture: relationship with molecular structure

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