The fate and effect of monensin during anaerobic digestion of dairy manure under mesophilic conditions

Arikan, Osman A.; Mulbry, Walter; Rice, Clifford P.; Lansing, Stephanie

doi:10.1371/journal.pone.0192080

Cited by 16 publications

(10 citation statements)

References 32 publications

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“…Although several other researchers have studied the fate and transformation of monensin in manure, the degradation mechanism of monensin by microorganisms is still unclear. Tandem mass spectrometry is a common and powerful technique that can be used to characterize the structure of unknowns and has been especially useful when associated with a ‘soft’ ionization technique such as electrospray .…”

Section: Resultsmentioning

confidence: 52%

Monensin biodegradation pathway and role of epoxide hydrolase in Stenotrophomonas maltophilia DM‐2

Wan

et al. 2020

J of Chemical Tech & Biotech

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BACKGROUND: Monensin is widely used in livestock and poultry production to promote animal growth and control coccidiosis. Most monensin is excreted as unchanged parent compounds via feces. However，monensin is very stable and difficult to degrade in the environment, and is potentially risky for the health of wildlife and humans. To date, the biodegradation process of monensin by bacteria and its mechanism is unclear. In this study, we found that a Stenotrophomonas maltophilia DM-2 strain isolated from chicken manure could effectively degrade monensin.RESULT: The optimum temperature and pH for DM-2 to degrade monensin were 40°C and pH 7.0. A potential degradation pathway of monensin was proposed based on the identification and characterization of two new monensin metabolic intermediates by liquid chromatography quadrupole time-of-flight mass spectroscopy. In addition, an inducible monensin-degrading activity was present in DM-2. A soluble epoxide hydrolysis (sEH) gene highly expressed in the DM-2 on day 3 and 6 under monensin stress, which was not observed in the DM-2 without monensin stress. When a specific inhibitor TPPU (1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea) of sEH was added into the cell-free extract, the degradation of monensin was inhibited.CONCLUSION: Strain DM-2 can biodegrade monensin by soluble epoxy hydrolase and produce two new intermediates. To our knowledge, this is the first report of the degradation of monensin by Stenotrophomonas strains. The novel metabolic pathways of monensin which we found may provide new insight into the environmental fate of monensin.

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Section: Resultsmentioning

confidence: 52%

Monensin biodegradation pathway and role of epoxide hydrolase in Stenotrophomonas maltophilia DM‐2

Wan

et al. 2020

J of Chemical Tech & Biotech

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“…From a social responsibility perspective, farmers are advised to respect the prescribed dosages and to use low toxic and degradable antibacterial agents. A number of antibiotics at their normal used levels was reported to have limited inhibition on methane production: tylosin, erythromycin, sulphamethazine, aminoglycosides, and monensin . Poels et al studied AD of swine waste in the presence of chlortetracycline, tylosin, chloramphenicol, erythromycin, bacitracin, and virginiamycin, and they observed negligible inhibitory effects of these drugs on methane production at recommended feed dosages.…”

Section: Controlling Strategiesmentioning

confidence: 99%

“…Similar observation was also obtained by Massé et al who studied the influences of six antibiotics (tylosin, lyncomycin, tetracycline, sulphamethazine, penicillin, and carbadox) on AD of swine manure; they reported a lack of noticeable impact of most antibacterial agents added to swine diet at prescribed levels except for tetracycline and penicillin. Arikan et al indicated that monensin did not significantly decrease methane yield at concentrations expected in dairy manure at recommended dosages. Yin et al reported that AD of manure containing chlortetracycline and oxytetracyline is feasible within certain limit.…”

Section: Controlling Strategiesmentioning

confidence: 99%

“…A number of antibiotics at their normal used levels was reported to have limited inhibition on methane production: tylosin, erythromycin, sulphamethazine, aminoglycosides, and monensin. [26,29,87,88] Poels et al [87] studied AD of swine waste in the presence of chlortetracycline, tylosin, chloramphenicol, erythromycin, bacitracin, and virginiamycin, and they observed negligible inhibitory effects of these drugs on methane production at recommended feed dosages. Similar observation was also obtained by Mass e et al [30] who studied the influences of six antibiotics (tylosin, lyncomycin, tetracycline, sulphamethazine, penicillin, and carbadox) on AD of swine manure; they reported a lack of noticeable impact of most antibacterial agents added to swine diet at prescribed levels except for tetracycline and penicillin.…”

Section: Regulationsmentioning

confidence: 99%

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Antibiotic Inhibition on Anaerobic Digestion of Animal Manure and Controlling Strategies: A Short Review

Yang

Huang

2018

CLEAN Soil Air Water

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Despite the efficacy of anaerobic digestion (AD) in stabilizing animal wastes as well as alleviating global warming associated with natural decomposition of animal manure, the process is susceptible to antibiotics that commonly exist in animal manure. Although antibiotics have served veterinary purposes in large quantities for decades, knowledge concerning their impacts on methane production during AD of animal manure is still in its infancy. Antibiotics used in animal practice are recognized as one of the major contributors to the development of resistant pathogens. Their fate and long‐term environmental impacts following land application or disposal of the animal manure into the aquatic environment, with resistance development and associated risks on human health as the primary focus, are well reviewed in many previous publications. To date, to the best of our knowledge, few efforts are made on reviewing the impacts of antibiotics on AD of animal manure and the mitigation strategies. In this review, detailed summaries of earlier and recent works conducted on the inhibition of antibiotics on AD of animal manure are presented, with special interest directed toward available and new controlling strategies in terms of technical and regulatory aspects. Finally, in view of process balance and successive operation, further research should be carried out to gain insight into dynamic interactions of antibiotics and other commonly seen coexistent inhibitors/intermediates in the AD systems.

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“…Monensin, the most widely used coccidiostat in the U.S. [16], is a class of polyether ion-carrier antibiotic used for the livestock and poultry industry. Monensin in fresh chicken manure can pose an environmental risk under certain conditions, and the use of compost was shown to be a method to degrade monensin [17].…”

Section: Introductionmentioning

confidence: 99%

Soil Behaviour of the Veterinary Drugs Lincomycin, Monensin, and Roxarsone and Their Toxicity on Environmental Organisms

Wang

et al. 2019

Molecules

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Lincomycin, monensin, and roxarsone are commonly used veterinary drugs. This study investigated their behaviours in different soils and their toxic effects on environmental organisms. Sorption and mobility analyses were performed to detect the migration capacity of drugs in soils. Toxic effects were evaluated by inhibition or acute toxicity tests on six organism species: algae, plants, daphnia, fish, earthworms and quails. The log Kd values (Freundlich model) of drugs were: lincomycin in laterite soil was 1.82; monensin in laterite soil was 2.76; and roxarsone in black soil was 1.29. The Rf value of lincomycin, roxarsone, monensin were 0.4995, 0.4493 and 0.8348 in laterite soil, and 0.5258, 0.5835 and 0.8033 in black soil, respectively. The EC50 for Scenedesmus obliquus, Arabidopsis thaliana, Daphnia magna and LC50/LD50 for Eisenia fetida, Danio rerio, and Coturnix coturnix were: 13.15 mg/L,32.18 mg/kg dry soil,292.6 mg/L,452.7 mg/L,5.74 g/kg dry soil and 103.9 mg/kg (roxarsone); 1.085 mg/L, <25 mg/kg dry soil, 21.1 mg/L, 4.76 mg/L, 0.346 g/kg dry soil and 672.8 mg/kg (monensin); 0.813 mg/L, 35.40 mg/kg dry soil, >400 mg/L, >2800 mg/L, >15 g/kg dry soil, >2000 mg/kg (lincomycin). These results showed that the environmental effects of veterinary drug residues should not be neglected, due to their mobility in environmental media and potential toxic effects on environmental organisms.

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The fate and effect of monensin during anaerobic digestion of dairy manure under mesophilic conditions

Cited by 16 publications

References 32 publications

Monensin biodegradation pathway and role of epoxide hydrolase in Stenotrophomonas maltophilia DM‐2

Monensin biodegradation pathway and role of epoxide hydrolase in Stenotrophomonas maltophilia DM‐2

Antibiotic Inhibition on Anaerobic Digestion of Animal Manure and Controlling Strategies: A Short Review

Soil Behaviour of the Veterinary Drugs Lincomycin, Monensin, and Roxarsone and Their Toxicity on Environmental Organisms

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