The familial incidence of intracranial aneurysms.

Vk, Kak; Gleadhill, Colin A.; Bailey, I. C.

doi:10.1136/jnnp.33.1.29

Cited by 29 publications

(7 citation statements)

References 21 publications

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“…Genetic influences probably contribute to the formation of aneurysms, as evidenced by some familial cases. 20,22,23 Of patients with subarachnoid hemorrhage, 7-20% have a first or second degree relative with a confirmed intracranial aneurysm. [24][25][26] Compared with sporadic cases of subarachnoid hemorrhage, familial aneurysms are more likely to rupture at an earlier patient age and are more likely to be associated with the formation of additional aneurysms.…”

Section: Epidemiologymentioning

confidence: 99%

Management of intracranial aneurysms

Chang

Steinberg

1998

Vasc Med

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Intracranial aneurysms are lesions commonly encountered by neurosurgeons, usually as a result of subarachnoid hemorrhage. The preferred treatment of these aneurysms is either surgical clipping or endovascular coiling, both of which eliminate the aneurysm from the normal circulation to prevent aneurysmal enlargement or additional hemorrhage. Despite advances over the last several decades in the understanding of intracranial aneurysms, morbidity from treatment of these lesions remains significant. This review will discuss the epidemiology, anatomy and pathophysiology, clinical and radiographic diagnosis, various treatment options, and potential complications from aneurysm treatment.

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Section: Epidemiologymentioning

confidence: 99%

Management of intracranial aneurysms

Chang

Steinberg

1998

Vasc Med

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“…Plusieurs auteurs présentent l'étude d'une seule famille en y exposant les cas (Ullrich et Sugar 1960;Graf 1966;Beumont 1968;Kak 1970;Brisman et Abbassioun 1971;Edelsohn et al 1972;Nagae et al 1972;Hashimoto 1977;Acosta-Rua 1978;Fox et Ko 1980;Fox 1982;Halal et al 1983;Berg et al 1987). Toutes ces études nous amènent à nous interroger de plus en plus sur les facteurs qui prédisposent ces individus à développer un anévrisme.…”

Section: éPidémiologie Génétiqueunclassified

“…Norrgard, en Suède, a rapporté une aggregation familiale chez 6,7% des cas d'anévrismes intracrâniens dans une série de 485 patients consécutifs présentant une hémorragie sous-arachnoïdienne par rupture d'anévrisme intracrânien (Norrgard et al 1987 Une autre indication de la prévalence des anévrismes intracrâniens familiaux nous est donnée dans une étude irlandaise de 337 cas d'anévrismes intracrâniens prouvés entre 1957 et 1965 (Chakravorty et Gleadhill 1966); parmi ceux-ci, ils ont retrouvé 6 cas (1,7%) familiaux (parents au premier degré) répartis dans trois familles. Quatre ans plus tard, le même groupe d'étude (Kak et Gleadhill 1970) rapporte 204 cas additionnels d'anévrismes intracrâniens dont 4 sont familiaux, ce qui porte la prévalence familiale à 1,8%. Toglia mentionne une série allemande publiée par Krayenbuhl et Yasargil dans laquelle on aurait retrouvé une prévalence familiale de 0,7% parmi 276 patients (Toglia 1972).…”

Section: éPidémiologie Génétiqueunclassified

“…En ce qui concerne les 20 couples apparentés au l^degré de cette étude, ceux-ci représentent 5,4% du nombre total d'individus; cela signifie que 20 individus sur 367 ont un lien d'apparentement étroit avec un autre individu de l'étude. Cette proportion dépasse largement (jusqu'à 3,9 fois plus élevée) la moyenne obtenue pour les grands groupes d'études (Chakravorty et Gleadhill 1966;Kak et Gleadhill 1970;Toglia 1972;Norrgard et al 1987). …”

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Epidemiologie genetique des anevrismes intracraniens familiaux au Saguenay-Lac-St-Jean

Gauthier¹

1992

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“…Many of these reports were reviewed by Bannerman, Ingall and Graf 12 and by Kak et al 13 From these reports it appears that occurrence of cerebral aneurysm may be influenced by inherited factors. Beumont 14 suggested a simple dominant pattern of inheritance for cerebral aneurysms with subsequent manifestation dependent upon variations in penetrance.…”

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confidence: 95%

Genetics of Cerebrovascular Accidents

Alter

Kluznik

1972

Stroke

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Genetics of Cerebrovascular Accidents• The influence of heredity factors in cerebrovascular accidents was investigated by studying the families of 80 patients with a clinical diagnosis of CVA. The frequency of CVA in parents and siblings of these patients was compared with the frequency in the family of the patient's spouse. The frequency of recognized predisposing illnesses to CVA including hypertension, diabetes and heart disease was also studied. The patients and the spouses were excluded from the study population.Analysis of the data obtained on 160 parents and 384 sibs of the proband and on 140 parents and 336 sibs of the spouse revealed a frequency of CVA of 10.7% and 8.6% respectively. This difference was not statistically significant. However, when the sibs and parents were analyzed separately the difference between the sibs was significant (p < 0.025), suggesting the possibility that a small added risk of CVA existed for certain close relatives of a CVA victim.Besides an inherited tendency to CVA, other factors were considered to account for the difference in frequency of CVA. Age, family size and differential reporting of illness failed to account for the difference. However, both hypertension and heart disease occurred with greater frequency in the sibs of the patient. When patients with these predisposing illnesses were excluded and those with CVA alone were compared, it was found that relatives of the patient and the spouse had essentially the same frequency (3.1% and 3.2% respectively). Moreover, hypertension and heart disease were significantly more common in the relatives of the proband. The excess of CVA in the sibs of the proband could, therefore, have been due to an excess of predisposing illnesses such as hypertension and heart disease, and no independent inheritance of CVA was demonstrated. In the absence of certain predisposing illness, close relatives of CVA patients appeared to have no greater risk of CVA than genetically unrelated individuals. ADDITIONAL KEY WORDS Predisposing illnesses to CVA hypertension diabetes heart disease cerebral infarction inheritance arterial occlusion vascular malformations • Early reports on hereditary factors in cerebrovascular accidents (CVA) consisted primarily of descriptions of CVA in individual families.

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The familial incidence of intracranial aneurysms.

Cited by 29 publications

References 21 publications

Management of intracranial aneurysms

Management of intracranial aneurysms

Epidemiologie genetique des anevrismes intracraniens familiaux au Saguenay-Lac-St-Jean

Genetics of Cerebrovascular Accidents

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