The Fallacy of the Fat Iron-Deficient Child

Judisch, Janifer M.; Naiman, J. Lawrence; Oski, Frank A.

doi:10.1542/peds.37.6.987

Cited by 47 publications

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The Nonhematologic Manifestations of Iron Deficiency

Oski¹

1979

Arch Pediatr Adolesc Med

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In the days of the Roman empire, medicinal iron was purported to produce "great effectes and marvelous works," as reported by Nicholas Monarde,1 a 16th century physician of Seville, Spain. Evidence exists that, even prior to that time, iron was employed for a variety of purposes in the major civilizations of the Mediterranean area and Asia.Today we tend to equate iron deficiency with anemia. Because iron deficiency anemia is easy to recognize and easy to treat, we have tended to overlook the nonhematologic manifestations of this heavy metal deficiency.The purpose of this review is to call attention to the fact that iron defi¬ ciency is more than just a blood disor¬ der.Iron-containing compounds in the body can be conveniently grouped into two large categories: those associated with hemoglobin, iron storage, and iron transport, and those known to serve other metabolic or enzymatic functions. Hemoglobin, ferritin, hemosiderin, and transferrin are in the first category and will not be From the

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The Nonhematologic Manifestations of Iron Deficiency

Oski¹

1979

Arch Pediatr Adolesc Med

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Iron-deficiency anemia in infant development: Implications for growth, cognitive development, resistance to infection, and iron supplementation

Ryan¹

1997

Am. J. Phys. Anthropol.

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Iron plays an important role in many metabolic processes, including oxygen transport, oxidative metabolism, and cellular growth. During infancy, inadequate supply of iron resulting in iron-deficiency anemia is associated with morbidity, impaired growth, and decreased behavior and psychomotor development. Although iron requirements during infancy have become better defined, iron-deficiency anemia persists as one of the most common health problems worldwide, a condition that affects approximately 20-25% of the world's infants. Today, much attention is being given to not only preventing iron-deficiency anemia but also to avoiding excessive iron supplementation. There is concern that excessive and widespread iron supplementation could lead to decreased resistance to infection and promotion of gastrointestinal illnesses. However, the literature on the relationship between iron status and chronic infection and disease contains conflicting viewpoints. Some investigators contend that mild iron-deficiency is beneficial for immunity whereas others argue that any deficits in iron status are detrimental. Iron absorption and metabolism are influenced by interactions between iron and other dietary nutrients. Many components of the diet act to inhibit or enhance iron absorption; this information is critical for food fortification programs designed to prevent iron-deficiency anemia worldwide. This paper reviews some of the biological characteristics of iron metabolism and absorption, iron needs during infancy, interactions of iron with other nutrients, methods for hematological assessment, iron-deficiency anemia and growth, the relationship between iron-deficiency anemia and infant psychomotor development, and the impact that iron supplementation has on resistance to infection and gastrointestinal illnesses. The serious consequences of iron-deficiency anemia for infant health, behavior and development, and the widespread prevalence of this disorder are reasons for its prevention. The benefits of oral supplementation of iron appear to outweigh the possibility of iron excess during infancy, a period of rapid growth and development characterized by a marginal dietary supply of iron.

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Nutrition and Growth in Infancy

Bergmann¹,

Bergmann²

1986

Methodology Ecological, Genetic, and Nutritional Effects on Growth

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The Fallacy of the Fat Iron-Deficient Child

Cited by 47 publications

References 0 publications

The Nonhematologic Manifestations of Iron Deficiency

The Nonhematologic Manifestations of Iron Deficiency

Iron-deficiency anemia in infant development: Implications for growth, cognitive development, resistance to infection, and iron supplementation

Nutrition and Growth in Infancy

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