The Faith of a Coronal Suture Grafted Onto Midline Synostosis Inducing Dura and Deprived From Tensile Stress

Mommaerts, Maurice Y.; Staels, Patrick F. J.

doi:10.1597/1545-1569(2001)038<0533:tfoacs>2.0.co;2

Cited by 6 publications

(2 citation statements)

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“…Reossification of the suturectomy site leads to the reapproximation of the osteotomy margins and the refusion of the extirpated suture, termed "resynostosis." (14)(15)(16)(17) Such resynostosis can lead to a secondary increase in intracranial pressure and further restrict craniofacial growth, (18)(19)(20) necessitating additional surgical procedures (21) and increasing the risk of patient morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Noggin Inhibits Postoperative Resynostosis in Craniosynostotic Rabbits

Cooper

Curry

Barbano

et al. 2007

Journal of Bone and Mineral Research

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Section: Introductionmentioning

confidence: 99%

Noggin Inhibits Postoperative Resynostosis in Craniosynostotic Rabbits

Cooper

Curry

Barbano

et al. 2007

Journal of Bone and Mineral Research

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“…Surgical therapy in coronal craniosynostosis routinely involves complete remodeling of the skull, due to the ineffectiveness of strip craniectomy in producing a normal head shape, although other surgical techniques have grown in popularity in recent years (Jane and Persing, 2000;Yano et al, 2006;Clayman et al, 2007). Even after total reconstruction of the skull, the area representing the suture may re-fuse shortly after surgery, requiring further surgical correction in some cases (Mommaerts et al, 2001;Panchal and Uttchin, 2003). Given the invasiveness of such procedures and the morbidity associated with craniofacial surgery, it would be advantageous to be able to prevent resynostosis and to reduce the likelihood of additional surgical procedures.…”

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confidence: 99%

Comparison of Craniofacial Phenotype in Craniosynostotic Rabbits Treated with Anti–Tgf-β2 at Suturectomy Site

Frazier

Mooney

Losken

et al. 2008

The Cleft Palate Craniofacial Journal

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Objective-Overexpression of transforming growth factor-beta 2 has been associated with craniosynostosis and resynostosis following surgery. We examined the effects of localized transforming growth factor-beta 2 inhibition on craniofacial phenotype in rabbits with craniosynostosis.Design-Twenty-five New Zealand white rabbits with bilateral coronal craniosynostosis were divided into three treatment groups: (1) suturectomy control (n = 8); (2) suturectomy with nonspecific, control immunoglobulin G antibody (n = 6); and (3) suturectomy with anti-transforming growth factor-beta 2 antibody (n = 11). At 10 days of age, a coronal suturectomy was performed on all rabbits. The sites in groups 2 and 3 were immediately filled with a slow-resorbing collagen gel mixed with either immunoglobulin G or anti-transforming growth factor-beta 2 antibody. Computed tomography scans of each rabbit were acquired at ages 10, 25, and 84 days. Craniofacial landmarks were collected from three-dimensional computed tomography reconstructions, and growth and form were compared among the three groups.Results-Rabbits treated with anti-transforming growth factor-beta 2 antibody differed in form at 84 days of age compared with suturectomy control rabbits, specifically in the snout and posterior neurocranium. Growth in some areas of the skull was greater in rabbits from the anti-transforming NIH Public Access Author ManuscriptCleft Palate Craniofac J. Author manuscript; available in PMC 2010 March 11. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript growth factor-beta 2 group than in suturectomy control rabbits, but not significantly greater than in IgG control rabbits.Conclusions-We find support for the hypothesis that transforming growth factor-beta 2 inhibition alters adult form, but these changes do not appear to be localized to the suturectomy region. Slight differences in form and growth between the two control groups suggest that the presence of the collagen vehicle itself may affect skull growth.Keywords coronal suturectomy; craniosynostosis; craniofacial; rabbits; Tgf-β2Craniosynostosis (i.e., premature fusion of one or more cranial sutures) impedes normal growth and development of the neurocranium and may result in associated abnormalities of the craniofacial complex (Babler, 1989; Cohen, 2000c;Richtsmeier, 2002). In humans, 95% of brain growth is completed by 6 years of age (Enlow, 1990), by which time the metopic suture has fused in about 90% of individuals. The remaining cranial sutures will not fuse fully until well into adulthood (Cohen, 2000b). The full impact of craniosynostosis on neurological development is not well understood. The early closure of even a single suture is widely thought to increase intracranial pressure (ICP) (Renier, 1989;Gault et al., 1992;Campbell et al., 1995;Thompson et al., 1995;Pollack et al., 1996;Hudgins et al., 1998;Mooney et al., 1998aMooney et al., , 1999 Jane and Persing, 2000;Fellows-Mayle et al., 2004), although this finding has been questioned because normative I...

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