The Failure of Pyridoxine in Suppression of Puerperal Lactation

Macdonald, H. N.; Collins, Y. D.; Wijayaratne, D. N.

doi:10.1111/j.1471-0528.1976.tb00730.x

Cited by 30 publications

(18 citation statements)

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“…The method of outcome assessment varied among the studies. Two studies assessed the effect of high‐dose pyridoxine use on prolactin levels, whereas pyridoxine efficacy was evaluated clinically in six of the studies . However, different parameters were used to describe clinical efficacy, including breast discomfort, breast consistency, breast engorgement and cessation of lactation.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, the total number of patients who received pyridoxine was not very large (n=471 patients), and sample size calculations were not presented in any of the included studies. Furthermore, the specific study designs were not clearly defined in the non‐randomized studies, and all of the studies included in the current review had been published for more than 35 years ago . Based on these observations, the strength of the current evidence is not sufficient to recommend the routine use of pyridoxine for post‐partum lactation inhibition in clinical practice.…”

Section: Discussionmentioning

confidence: 97%

“…The increase in dopamine formation in hypothalamic neurons and their major dendrites is thought to result in prolactin inhibition and consequent lactation inhibition . Studies of the efficacy of pyridoxine in lactation suppression have reported conflicting results …”

Section: What Is Known and Objectivementioning

confidence: 99%

“…14 Studies of the efficacy of pyridoxine in lactation suppression have reported conflicting results. 14,15 No systematic review explicitly investigated the efficacy and safety of pyridoxine for post-partum lactation suppression. The objective of this systematic review was to evaluate the effectiveness and safety of pyridoxine in the inhibition of post-partum lactation.…”

Section: What Is Known and Objectivementioning

confidence: 99%

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Is pyridoxine effective and safe for post-partum lactation inhibition? A systematic review

et al. 2017

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SummaryWhat is known and objective: It has been suggested that pyridoxine has an antilactogenic effect. Studies of the efficacy of pyridoxine in suppressing lactation have reported conflicting results. The aim of this review was to evaluate the effectiveness and safety of high-dose pyridoxine in post-partum lactation inhibition. Methods:This systematic review included published trials that compared the efficacy and/or safety of pyridoxine to placebo or to other pharmacological agents for the inhibition of post-partum lactation. We searched PubMed, Embase, ScienceDirect, CINAHL, AMED, the Cochrane library and the clinical trials registry to identify relevant literature. No limit was imposed on the year of publication of the studies, and the review included studies published until 15 January 2016. Two reviewers independently extracted data and assessed the risk of bias. Results and discussion:Seven studies were included, with a total of 1155 women, of which 471 women received pyridoxine. Three studies were randomized controlled trials, whereas the remaining four studies were non-randomized controlled trials. All of the included studies were relatively small (n=18-482). The studies compared pyridoxine with placebo, bromocriptine and/or stilboestrol. Pyridoxine was given orally, with a total daily dose of 450-600 mg for 5-7 days. Two trials (n=349 participants) indicated that pyridoxine was effective in inhibiting lactation in approximately 95% of the enrolled patients. All other studies failed to demonstrate pyridoxine efficacy through either clinical assessment or prolactin level measurements. Pyridoxine safety was assessed by two trials in which no serious untoward side effects were reported. Overall, the risk of bias for most of the studies was low to moderate.What is new and conclusion: Current evidence supporting the effectiveness of highdose pyridoxine in the inhibition of post-partum lactation is inconsistent and insufficient. Larger randomized trials are needed to confirm the efficacy of pyridoxine in post-partum lactation inhibition. K E Y W O R D Sbreastfeeding, lactation inhibition, lactation suppression, pyridoxine, vitamin B6

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Section: What Is Known and Objectivementioning

confidence: 99%

Section: What Is Known and Objectivementioning

confidence: 99%

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Is pyridoxine effective and safe for post-partum lactation inhibition? A systematic review

et al. 2017

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“…Oestrogens, either alone or in combination with androgens, have been widely used for this purpose. Pyridoxine in high doses has been tried but the results have been largely disappointing (6). Also alarming is the increased risk of associated thromboembolism (5).…”

Section: Suppression Of Puerperal Lactation Using Jasmine Flowers (Jamentioning

confidence: 99%

Suppression of Puerperal Lactation Using Jasmine Flowers (Jasminum Sambac)

Shrivastav

George

Balasubramaniam

et al. 1988

Aust NZ J Obst Gynaeco

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The efficacy of jasmine flowers (Jasminum Sambac) applied to the breasts to suppress puerperal lactation was compared that of Bromocriptine. Effectiveness of both regimens was monitored by serum prolactin levels, clinical evaluation of the degree of breast engorgement and milk production and the analgesic intake. While both bromocriptine and jasmine flowers brought about a significant reduction in serum prolactin, the decrease was significantly greater with bromocriptine. However, clinical parameters such as breast engorgement, milk production and analgesic intake showed the 2 modes of therapy to be equally effective. The failure rates of the 2 regimens to suppress lactation were similar; however, rebound lactation occurred in a small proportion of women treated with bromocriptine. Jasmine flowers seem to be an effective and inexpensive method of suppressing puerperal lactation and can be used as an alternative in situations where cost and nonavailability restrict the use of bromocriptine.

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Treatments for suppression of lactation

Oladapo

Fawole

2009

Cochrane Database of Systematic Reviews

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The Failure of Pyridoxine in Suppression of Puerperal Lactation

Cited by 30 publications

References 1 publication

Is pyridoxine effective and safe for post-partum lactation inhibition? A systematic review

Is pyridoxine effective and safe for post-partum lactation inhibition? A systematic review

Suppression of Puerperal Lactation Using Jasmine Flowers (Jasminum Sambac)

Treatments for suppression of lactation

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