The failure of oxygen breathing to decrease the myocardial contractile force in denervated dogs.

Ishikawa, Kinji; Kanamasa, Ken; Yamakado, Tetsu; Kohashi, Yasuyuki; Katori, Ryo

doi:10.1253/jcj.47.824

Cited by 2 publications

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“…It is surprising that even the usefulness of 02 inhalation therapy, one of the oldest and most widely applied treatments, is also still an unsettled question. This paper confirms the efficacy of 100% 02 inhalation in treatment of acutely-induced myocardial ischemia and discusses the conflicting information (Saltzman 1975;Ishikawa et al 1983) currently available on this conventional treatment.…”

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confidence: 62%

“…The fact that 02 breathing reduces myocardial contractile force has been shown repeatedly in experimental animals ( 'Ishikawa et al 1974b) as well as in clinical patients with ischemic myocardium (Ishikawa et al 1974c), although effects of 02 on myocardial contractile force is rather complicated (Ishikawa et al 1983). Since myocardial contractile force is one of the major determinants of myocardial 02 consumption (Sonnenblick et al 1968), a decrease in myocardial contractile force in the ischemic myocardium will also reduce myocardial ischemia.…”

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confidence: 97%

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The beneficial effects of 40% and 100% O2 inhalations on acutely-induced myocardial ischemia in dogs.

Ishikawa

Kanamasa

Yamakado

et al. 1986

Tohoku J. Exp. Med.

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The effectiveness of 02 inhalation on the acutely-induced ischemic myocardium in dogs was investigated. In 22 open-chest mongrel dogs, the left anterior descending coronary artery was partially occluded to reduce coronary flow. The regional coronary vein accompanying the artery was cannulated to obtain coronary venous blood. Switching of inspiratory gas from room air to 40% 02 produced an elevation of coronary venous 02 saturation from 35.8 + 12.7 (s.D.) to 41.1 + 11.9% and shifting of myocardial lactate production to utilization (from -0.9+36.9 to 5.0+36.7%), indicating that 40% 02 inhalation ameliorated ischemia. Application of 100% 02 inhalation caused even more beneficial effects ; coronary venous 02 saturation was elevated to 50.6±12.6% and myocardial lactate extraction was improved to 7.8+ 40.5%. The present study indicated that 40% 0 inhalation was effective and 100% 02 inhalation even more effective in ameliorating acutely-induced myocardial ischemia. Decreases in myocardial contractile force and left ventricular size and suppresion of sympathoadrenal activity might be possible mechanisms for these beneficial effects.

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confidence: 62%