The factorial structure of the Chronic Liver Disease Questionnaire (CLDQ)

Schulz, Karl‐Heinz; Kroencke, Sylvia; Ewers, Heike; Schulz, Holger; Younossi, Zobair M.

doi:10.1007/s11136-008-9332-7

Cited by 48 publications

(53 citation statements)

References 23 publications

(69 reference statements)

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“…Namely, for internal consistency, mean Cronbach's α fitted the defined criteria [19] , which was consistent with reports from the original CLDQ [8,20] and European CLDQ validation studies [12,13] . Retest reliability was not assessed, which should be regarded as a limitation of this study.…”

Section: Discussionsupporting

confidence: 85%

“…Convergent validity measures the extent to which domains in an instrument correlate with others that assess a similar concept, according to derived hypotheses [19] . In accordance with previous work correlating CLDQ with SF-12 domains [12,20] , we hypothesized high correlations ( r > 0.70) between: Fatigue (CLDQ) and Vitality (SF-12); Activity (CLDQ) and Physical Functioning (SF-12); Emotional Function (CLDQ) and Mental Health (SF-12) [12,20] . Discriminant validity refers to the extent to which a measure does not correlate too strongly with measures intended to assess different traits.…”

Section: Cldq Portuguese Version: Psychometric Propertiessupporting

confidence: 85%

“…The level of significance was set at p < 0.05 or p < 0.01. IC: α = 0.95 overall (α = 0.72 Activity to α = 0.92 Fatigue) [20]; TRR: r = 0.69 to r = 0.79 [20]; CV: worse CLDQ scores with increased disease severity [5] Scoring and interpretation…”

Section: Discussionmentioning

confidence: 99%

“…Discriminant validity refers to the extent to which a measure does not correlate too strongly with measures intended to assess different traits. [12,20] .…”

Section: Cldq Portuguese Version: Psychometric Propertiesmentioning

confidence: 99%

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Health-Related Quality of Life in Portuguese Patients with Chronic Hepatitis C

Rei

Rocha

Pedroto

2016

GE Port J Gastroenterol

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Introduction: Chronic hepatitis C virus (HCV) infection impacts multiple health and psychosocial dimensions and encompasses a significant overall burden as it progresses to advanced stages of hepatic disease. Aims: To evaluate for the first time health-related quality of life (HRQoL) of a subset of Portuguese adult patients with chronic hepatitis C using the Portuguese versions of generic, Short-Form 12 Health Survey (SF-12v2), and disease-specific, Chronic Liver Disease Questionnaire (CLDQ), instruments; to assess psychometric properties of CLDQ, Portuguese version. Methods: HRQoL was evaluated in Portuguese adult outpatients with chronic hepatitis C attending the Hepatology Clinic at Centro Hospitalar do Porto, using SF-12v2 and CLDQ. This transversal study was conducted between April and October 2015. Results: Eighty outpatients with chronic hepatitis C were enrolled, with mean age 57 years (standard deviation 11), 67.5% male, all Caucasian, 76.3% diagnosed for >10 years, 66.3% with C virus genotype 1, 65.0% with hepatic cirrhosis (94.2% of which Child-Pugh A), and 46.3% under current antiviral treatment. For CLDQ internal consistency, Cronbach's α was 0.88; for construct validity, correlations ranged from 0.36 to 0.80 (p < 0.01). Mean CLDQ scores ranged from 4.25 (Worry) to 5.78 (Abdominal Symptoms). Lower scores were observed for Worry, Fatigue, and Emotional Function domains. Statistically significant differences were found in median values of Worry (CLDQ) and Role Emotional (SF-12) (p < 0.05) for “current antiviral treatment,” with higher scores for patients that concluded therapy. Conclusion: HRQoL was negatively affected in several domains in Portuguese patients with chronic hepatitis C; oral antiviral treatment correlated with better quality of life, assuring its benefits on this population; the CLDQ Portuguese version revealed adequate psychometric properties, and was useful in assessing quality of life in Portuguese HCV patients.

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Section: Discussionsupporting

confidence: 85%

Section: Cldq Portuguese Version: Psychometric Propertiessupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

“…Discriminant validity refers to the extent to which a measure does not correlate too strongly with measures intended to assess different traits. [12,20] .…”

Section: Cldq Portuguese Version: Psychometric Propertiesmentioning

confidence: 99%

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Health-Related Quality of Life in Portuguese Patients with Chronic Hepatitis C

Rei

Rocha

Pedroto

2016

GE Port J Gastroenterol

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“…The factor structure of the Chinese (HK) CLDQ version was almost identical to the original CLDQ in four subscales (EF, WO, AS and AC). The new factor of Sleep found in our Chinese population was also found in the Spanish, Italian and German population [9,10,27] . CHB patients may have sleep difficulties due to reasons other than emotional problems, such as pain and other symptoms.…”

Section: Discussionsupporting

confidence: 80%

Psychometrics of the chronic liver disease questionnaire for Southern Chinese patients with chronic hepatitis B virus infection

Lam¹,

Lam²,

Lai³

et al. 2009

WJG

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AIM:To test the psychometric properties of a Chinese [(Hong Kong) HK] translation of the chronic liver disease questionnaire (CLDQ). METHODS:A Chinese (HK) translation of the CLDQ was developed by iterative translation and cognitive debriefing. It was then administered to 72 uncom plicated and 78 complicated chronic hepatitis B (CHB) patients in Hong Kong together with a structured questionnaire on service utilization, and the Chinese (HK) SF36 Health Survey Version 2 (SF36v2). RESULTS:Scaling success was ≥ 80% for all but three items. A new factor assessing sleep was found and items of two (Fatigue and Systemic Symptoms) subscales tended to load on the same factor. Internal consistency and testretest reliabilities ranged from 0.580.90 for different subscales. Construct validity was confirmed by the expected correlations between the SF36v2 Health Survey and CLDQ scores. Mean scores of CLDQ were significantly lower in complicated compared with uncomplicated CHB, supporting sensitivity in detecting differences between groups. CONCLUSION:The Chinese (HK) CLDQ is valid, reliable and sensitive for patients with CHB. Some modifi cations to the scaling structure might further improve its psychometric properties.

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Clinical validation of the chronic liver disease questionnaire for the Chinese population in Singapore

et al. 2019

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Background and Aim Assessment of health‐related quality‐of‐life (HRQOL) in patients with chronic liver disease (CLD) requires the use of validated instruments that are understood by patients in their native language. We previously translated the Chronic Liver Disease Questionnaire into the Singapore‐Mandarin version (CLDQ‐SG). This study aims to examine the internal consistency and validity of the CLDQ‐SG in patients with CLD. Methods We conducted a cross‐sectional study of adult patients with CLD seen in a tertiary center in Singapore who completed both the CLDQ‐SG and Short Form Health Survey 36 version 2 (SF‐36v2) questionnaires. Internal consistency of the CLDQ‐SG was assessed using Cronbach's alpha coefficient. Convergent and divergent validity of the SF‐36v2 was assessed using the Spearman correlation coefficient, while discriminant validity was assessed using the Jonckheere‐Terpstra test for trend. Exploratory factor analysis was performed to evaluate the factor structure of the CLDQ‐SG. Results We enrolled 242 subjects (68.2% males, median age 67 years). Predominant etiology of CLD was chronic hepatitis B. Severity of CLD was divided into noncirrhotic (67.3%), compensated cirrhosis (24.0%), and decompensated cirrhosis (8.7%). Item convergent and discriminant validity of the CLDQ‐SG was excellent, with 100% scaling success in all six domains. All domains exhibited good internal consistency, with Cronbach's α > 0.70. We observed a consistent trend of a reduction in mean CLDQ‐SG score in the three groups reflecting the discriminant validity of the CLDQ‐SG to assess changes in HRQOL in different severities of CLD. Factor analysis of the CLDQ‐SG demonstrated an independent factor assessing sleep. Conclusion The Singapore‐Mandarin version of CLDQ‐SG is a valid and reliable instrument to measure HRQOL in patients with CLD.

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The factorial structure of the Chronic Liver Disease Questionnaire (CLDQ)

Abstract: CLDQ's reliability and validity have been confirmed. In addition, the demonstrated practical administration of the questionnaire suggests that it should serve as a routine quality of life assessment of patients with chronic liver disease.

Cited by 48 publications

References 23 publications

Health-Related Quality of Life in Portuguese Patients with Chronic Hepatitis C

Health-Related Quality of Life in Portuguese Patients with Chronic Hepatitis C

Psychometrics of the chronic liver disease questionnaire for Southern Chinese patients with chronic hepatitis B virus infection

Clinical validation of the chronic liver disease questionnaire for the Chinese population in Singapore

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