The factor structure for the Positive and Negative Syndrome Scale (PANSS) in recent-onset psychosis

Emsley, Robin; Rabinowitz, Jonathan; Torreman, Martijn

doi:10.1016/s0920-9964(02)00302-x

Cited by 335 publications

(229 citation statements)

References 55 publications

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“…PANSS scores revealed high levels of positive and negative symptoms, signifying a relatively severe level of illness-mean PANSS subscale scores in this sample appear to have been greater than those reported in other first-episode samples, [22,23] although no direct comparison of means was calculated. Furthermore, the median DUP in this sample (42 weeks) was relatively consistent with those reported from other first-episode cohorts [24][25][26][27][28].…”

Section: Discussioncontrasting

confidence: 75%

The period of untreated psychosis before treatment initiation:

Bergner

Leiner

Carter

et al. 2008

Comprehensive Psychiatry

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Aim-This study employed a qualitative research methodology to explore common themes pertaining to the period of untreated psychosis prior to treatment initiation in hospitalized, urban, African American, first-episode psychosis patients.Methods-Twelve family members of 10 patients were interviewed at length to gather detailed narrative accounts of factors related untreated psychosis and treatment delay. Using qualitative analysis, verbatim transcripts were reviewed by two researchers to identify prominent themes useful for generating future research hypotheses.Results-Four themes emerged as informative of the period of untreated psychosis prior to treatment initiation: (1) misattribution of symptoms or problem behaviors (e.g., depression, drug use, adolescent rebellion), (2) positive symptoms causing unusual or dangerous behaviors that served as a catalyst for initiating treatment, (3) views about personal autonomy of an adult or nearly adult patient, and (4) system-level factors (e.g., unaffordability of healthcare, inefficiency on the part of healthcare providers).Conclusions-Family members encountered numerous barriers when seeking treatment, including their own misattributions, the nature of the patient's symptoms, financial issues, and system-level delays. The themes uncovered in this formative analysis merit further exploration with additional qualitative and quantitative research.

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Section: Discussioncontrasting

confidence: 75%

The period of untreated psychosis before treatment initiation:

Bergner

Leiner

Carter

et al. 2008

Comprehensive Psychiatry

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“…[10][11][12] Our model accounted for 58.44% of the total variance; this is very similar to previous results, which ranged from 53.4 to 59.83%. 7,10 As in other studies, the internal consistency we obtained was good (. 0.8) for the negative and disorganized factors, and acceptable (.…”

Section: Discussionsupporting

confidence: 91%

“…0.7) for the remaining factors. 10,13 Regarding the composition of individual factors, the negative factor accounted for the greatest individual contribution to variance in the final model (27.97%). 7 The second most robust factor was the ''disorganization/ cognitive'' (11.75%).…”

Section: Discussionmentioning

confidence: 99%

“…The positive, depression/anxiety, and disorganization/cognition factors were similar to previous studies. 7,8,10,12,13 Regarding the sixth factor found and not included in the final model, Emsley et al 10 performed a study of the PANSS factor structure in recent-onset psychosis. They suggested that the five-factor model did not suffice to show the structure of the PANSS, because a seven-factor model emerged in the exploratory phase of their study with a last factor named ''motor.''…”

Section: Discussionmentioning

confidence: 99%

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Factor structure of the Positive and Negative Syndrome Scale (PANSS) in Brazil: convergent validation of the Brazilian version

Higuchi

Ortiz

Berberian

et al. 2014

Rev. Bras. Psiquiatr.

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Objectives: The Positive and Negative Syndrome Scale (PANSS) was developed to assess the symptoms of schizophrenia dimensionally. Although it is widely used in clinical trials in Brazil, it is not fully validated. The aim of this study is to assess the factor structure of the Brazilian PANSS and generate validation data for its current version. Methods: A total of 292 patients diagnosed with schizophrenia were enrolled. Results: Principal component analysis suggested a forced five-factor final model that accounted for 58.44% of the total variance, composed of negative, disorganization/cognition, excitement, positive, and depression/anxiety. Conclusion: The Brazilian PANSS has a similar factor structure and internal consistency compared to versions in several other languages.

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“…As an initial exploration of this area, we chose to examine two nonpsychotic but clinically relevant domains, attentional impairment 127,128 and anxiety. 129,130 Both domains can present as early as preschool age. The relationship between infant sensory gating and preschool symptomology was explored in 48 children (24 with robust infant P50 sensory gating and 24 with impaired P50 sensory gating).…”

Section: The Endophenotype Predicts Elevated Risk For Schizophrenia-amentioning

confidence: 99%

Endophenotypes in Schizophrenia for the Perinatal Period: Criteria for Validation

Ross

Freedman

2015

SCHBUL

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Endophenotypes are disease-associated phenotypes that are thought to reflect the neurobiological or other mechanisms that underlie the more overt symptoms of a psychiatric illness. Endophenotypes have been critical in understanding the genetics, neurobiology, and treatment of schizophrenia. Because psychiatric illnesses have multiple causes, including both genetic and nongenetic risk factors, an endophenotype linked to one of the mechanisms may be expressed more frequently than the disease itself. However, in schizophrenia research, endophenotypes have almost exclusively been studied in older adolescents or adults who have entered or passed through the age of risk for the disorder. Yet, schizophrenia is a neurodevelopmental disorder where prenatal development starts a cascade of brain changes across the lifespan. Endophenotypes have only minimally been utilized to explore the perinatal development of vulnerability. One major impediment to the development of perinatally-useful endophenotypes has been the established validity criteria. For example, the criterion that the endophenotype be more frequently present in those with disease than those without is difficult to demonstrate when there can be a decades-long period between endophenotype measurement and the age of greatest risk for onset of the disorder. This article proposes changes to the endophenotype validity criteria appropriate to perinatal research and reviews how application of these modified criteria helped identify a perinatally-usable phenotype of risk for schizophrenia, P50 sensory gating, which was then used to propose a novel perinatal primary prevention intervention.

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The factor structure for the Positive and Negative Syndrome Scale (PANSS) in recent-onset psychosis

Cited by 335 publications

References 55 publications

The period of untreated psychosis before treatment initiation:

The period of untreated psychosis before treatment initiation:

Factor structure of the Positive and Negative Syndrome Scale (PANSS) in Brazil: convergent validation of the Brazilian version

Endophenotypes in Schizophrenia for the Perinatal Period: Criteria for Validation

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