The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer
Wen-Jing Yun,
Jun Li,
Nan-Chang Yin
et al.
Abstract:Keratin 80 (KRT80) is a filament protein that makes up one of the major structural fibers of epithelial cells, and involved in cell differentiation and epithelial barrier integrity. Here, KRT80 mRNA expression was found to be higher in esophageal cancer than normal epithelium by RT-PCR and bioinformatics analysis (
p
< .05), opposite to KRT80 methylation (
p
< .05). There was a negative relationship between promoter methylation and expression level of KRT80 gene in… Show more
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