The fabrication of iron oxide nanoparticle‐nanofiber composites by electrospinning and their applications in tissue engineering

Abstract

This paper reviews the use of iron oxide nanoparticle-nanofiber composites in tissue engineering with a focus on the electrospinning technique. Electrospinning is an established method of scaffold fabrication offering a number of key advantages which include its facile nature, with electrospun materials offering a high surface area to volume ratio, potential for the release of drugs and antimicrobials, controllable fiber diameters and high porosity and permeability. A number of different techniques for the preparation of iron oxide nanoparticles including their functionalization are discussed along with their applications in the biomedical field. The review then focusses on the fabrication of nanoparticle-nanofiber composite scaffolds formed using electrospinning. The advantages and disadvantages of current fabrication techniques are discussed including the fabrication of nanofibers using pre-synthesized nanoparticles and post-treatment synthesized nanoparticles. We demonstrate that emerging in-situ synthesis techniques show promise by offering a reduced number of steps and simpler procedures for the production of magnetic scaffolds. These scaffolds have a number of applications in tissue engineering, allowing for improved bone and tissue repair.

Advances in Magnetic Nanoparticles for Biomedical Applications

“…Several different methods exist to produce scaffolds for tissue engineering. Most common are jetting methodologies such as aerodynamically assisted jetting/ threading, pressure‐assisted/driven jetting/spinning, laser‐guided writing, inkjet printing, electrospray, and electrospinning . Printing, electrospray, and electrospinning are currently undergoing a widespread revival of scientific investigation of chemical, physical, and biological outputs, being able to produce structures more similar in size to the natural extracellular matrix …”

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

“…It showed that the combined action of magnetic nanoparticles and the magnetic field can promote bone repair (Tang et al, 2017;Yang et al, 2018). Magnetic nanoparticles have been proven to promote bone tissue regeneration mainly through the magnetic force generated by itself and the external magnetic field (Mortimer and Wright, 2017;Lin et al, 2018b;Fernandes et al, 2019). Fernandes et al studied the effect of an FIGURE 4 | The schematic representation of the fabrication of a three-dimensional scaffold using a magnetoacoustics' field, including the assembly and recrystallization of the scaffold.…”

Preparation of electrospun magnetic polyvinyl butyral/Fe2O3 nanofibrous membranes for effective removal of iron ions from groundwater

“…Electrospun nanofibrous membranes containing an amount of magnetic iron oxide nanoparticles have become a necessary material for various uses, including tissue engineering, sensors, wound dressings, magnetic hyperthermia therapy, and wastewater treatment. [1][2][3][4][5][6][7] It is possible to incorporate magnetic nanoparticles (MNPs) into a nanofibrous membrane in three different ways: (a) by utilizing pre-synthesized MNPs prior to electrospinning;…”