The fabrication of a highly efficient self-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healing

Wang, Chun-Yao; Liang, Cheng; Wang, Rui; Yao, Xueliang; Guo, Peng; Yuan, Weizhong; Liu, Yang; Song, Ye; Li, Zhihong; Xie, Xiaoyun

doi:10.1039/c9bm01207a

Cited by 115 publications

(87 citation statements)

References 40 publications

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“…They immobilized the bone-forming peptides-1 (BFP-1) using this technique, which allowed a slow release of BFP-1 and showed that combining hASCs and PLGA/pDA can enhance bone formation [ 64 ]. Most recently, Wang et al described a highly efficient injectable self-healing hydrogel fabrication using a Schiff base linkage for applications in severe wound healing [ 61 ]. They constructed a methyl-cellulose (MC)–chitosan (CS) combination of a hydrogel with placental cell-derived exosomes.…”

Section: Exosomes and Hydrogelsmentioning

confidence: 99%

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Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering

Khayambashi

Iyer

Pillai

et al. 2021

IJMS

107

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Tissue engineering has been an inveterate area in the field of regenerative medicine for several decades. However, there remains limitations to engineer and regenerate tissues. Targeted therapies using cell-encapsulated hydrogels, such as mesenchymal stem cells (MSCs), are capable of reducing inflammation and increasing the regenerative potential in several tissues. In addition, the use of MSC-derived nano-scale secretions (i.e., exosomes) has been promising. Exosomes originate from the multivesicular division of cells and have high therapeutic potential, yet neither self-replicate nor cause auto-immune reactions to the host. To maintain their biological activity and allow a controlled release, these paracrine factors can be encapsulated in biomaterials. Among the different types of biomaterials in which exosome infusion is exploited, hydrogels have proven to be the most user-friendly, economical, and accessible material. In this paper, we highlight the importance of MSCs and MSC-derived exosomes in tissue engineering and the different biomaterial strategies used in fabricating exosome-based biomaterials, to facilitate hard and soft tissue engineering.

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Section: Exosomes and Hydrogelsmentioning

confidence: 99%

“…The MC- and CS-grafted polyethylene glycol were synthesized using DCC (dicyclohexyl- carbodiimide) and EDC (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide) reactions. Both these polymer solutions were mixed together along with exosomes to fabricate the complex hydrogel [ 61 ].…”

Section: Exosomes and Hydrogelsmentioning

confidence: 99%

Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering

Khayambashi

Iyer

Pillai

et al. 2021

IJMS

107

View full text Add to dashboard Cite

show abstract

“…Rapid and robust self-healing properties were demonstrated by the hydrogels obtained by Schiff-base reactions between aldehyde groups of modified methyl cellulose and the amine groups of PEG-grafted chitosan. The gels were explored as scaffolds for the loading of exosomes and this combination led to a synergistic improvement of their wound healing ability [ 128 ].…”

Section: Tissue Engineering Applicationsmentioning

confidence: 99%

Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

et al. 2020

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In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.

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“…Ce travail démontre une nouvelle approche pour augmenter la livraison du traitement de l'infarctus du myocarde. Liu et al ont rapporté que le chargement d'EV avec un nouveau complexe d'hydrogels peut favoriser la cicatrisation des plaies, ce qui fournit une autre stratégie d'hydrogel efficace pour l'ingénierie des EV 7 . Li et al ont étudié les rôles d'Exo-pGel dans le traitement des lésions de la moelle épinière.…”

Section: Techniques D'ingenierie Artificielle Des Vési-cules Et Des Nunclassified

Engineered Extracellular Vesicles And Nanoparticles: Promising Tools For Disease Treatment

WANG¹,

Zhu²,

Xiao³

2020

Arch Balk Med Union

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The fabrication of a highly efficient self-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healing

Abstract: Highly efficient self-healing hydrogels from natural biopolymers loaded with exosome biological nanoparticles for the synergistic promotion of severe wound healing are demonstrated.

Cited by 115 publications

References 40 publications

Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering

Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering

Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

Engineered Extracellular Vesicles And Nanoparticles: Promising Tools For Disease Treatment

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