The f-ratio quantification method applied to standard minerals with a cold field emission SEM/EDS

Teng, Chaoyi; Yuan, Yu; Gauvin, Raynald

doi:10.1016/j.talanta.2019.05.107

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Currently, several bacterial, viral, and parasitic pathogens were subjected for aptamer selection to detect or inhibit infection. 73,97,98 An extensive aptamer library for identification of specific pathogens as well as a means to discriminate pathogens expressing or lacking key virulence factors could greatly improve the current diagnostic process and therapy. Given the physicochemical and economic advantages of aptamers over antibodies, the development of treatment and diagnosis against infectious organisms based on aptamers may prove as viable in less developed countries.…”

Section: Organization Of Aptamers Into Complex Structuresmentioning

confidence: 99%

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

et al. 2019

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Nucleic acids play a central role in all domains of life, either as genetic blueprints or as regulators of various biochemical pathways. The chemical makeup of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), generally represented by a sequence of four monomers, also provides precise instructions for folding and higher-order assembly of these biopolymers that, in turn, dictate biological functions. The sequence-based specific 3D structures of nucleic acids led to the development of the directed evolution of oligonucleotides, SELEX (systematic evolution of ligands by exponential enrichment), against a chosen target molecule. Among the variety of functions, selected oligonucleotides named aptamers also allow targeting of cell-specific receptors with antibody-like precision and can deliver functional RNAs without a transfection agent. The advancements in the field of customizable nucleic acid nanoparticles (NANPs) opened avenues for the design of nanoassemblies utilizing aptamers for triggering or blocking cell signaling pathways or using aptamer-receptor combinations to activate therapeutic functionalities. A recent selection of fluorescent aptamers enables real-time tracking of NANP formation and interactions. The aptamers are anticipated to contribute to the future development of technologies, enabling an efficient assembly of functional NANPs in mammalian cells or in vivo. These research topics are *

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Section: Organization Of Aptamers Into Complex Structuresmentioning

confidence: 99%

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

et al. 2019

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“…SEM can be used to analyze the crystalline structure, surface topography, electrical behavior, and chemical composition of approximately 1 µm of the top part of a specimen [11]. The behavior of the specimen under several conditions can be investigated using SEM, as a variety of specialized stages can be applied, such as cold [14], hot [15], or in situ mechanical testing [16]. For instance, cathodoluminescence (emission of light) works very well for temperatures near absolute zero compared to room temperature [17,18].…”

Section: Introductionmentioning

confidence: 99%

Mineral Characterization Using Scanning Electron Microscopy (SEM): A Review of the Fundamentals, Advancements, and Research Directions

Ali,

Zhang,

Santos

2023

Applied Sciences

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Scanning electron microscopy (SEM) is a powerful tool in the domains of materials science, mining, and geology owing to its enormous potential to provide unique insight into micro and nanoscale worlds. This comprehensive review discusses the background development of SEM, basic SEM operation, including specimen preparation and image processing, and the fundamental theoretical calculations underlying SEM operation. It provides a foundational understanding for engineers and scientists who have never had a chance to dig in depth into SEM, contributing to their understanding of the workings and development of this robust analytical technique. The present review covers how SEM serves as a crucial tool in mineral characterization, with specific discussion on the workings and research fronts of SEM-EDX, SEM-AM, SEM-MLA, and QEMSCAN. With automation gaining pace in the development of all spheres of technology, understanding the uncertainties in SEM measurements is very important. The constraints in mineral phase identification by EDS spectra and sample preparation are conferred. In the end, future research directions for SEM are analyzed with the possible incorporation of machine learning, deep learning, and artificial intelligence tools to automate the process of mineral identification, quantification, and efficient communication with researchers so that the robustness and objectivity of the analytical process can be improved and the analysis time and involved costs can be reduced. This review also discusses the idea of integrating robotics with SEM to make the equipment portable so that further mineral characterization insight can be gained not only on Earth but also on other terrestrial grounds.

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The f-ratio model for quantitative X-ray microanalysis

Teng

Gauvin

2021

Talanta

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The f-ratio quantification method applied to standard minerals with a cold field emission SEM/EDS

Cited by 5 publications

References 24 publications

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

Mineral Characterization Using Scanning Electron Microscopy (SEM): A Review of the Fundamentals, Advancements, and Research Directions

The f-ratio model for quantitative X-ray microanalysis

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