The Eyes in Sarcoidosis

Crick, Ronald Pitts; Hoyle, Clifford; Smellie, Hugh

doi:10.1136/bjo.45.7.461

Cited by 173 publications

(79 citation statements)

References 18 publications

(5 reference statements)

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“…The prevalence of disease manifestation in the eye has been demonstrated in 25-50% of the patients [1][2][3][4][5][6] . The inflammatory lesions can cause visual loss, typically as a result of secondary glaucoma, macular edema, retinal scars or optic neuritis [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

The Eye as a Common Site for the Early Clinical Manifestation of Sarcoidosis

Heiligenhaus

Wefelmeyer²,

Wefelmeyer³

et al. 2010

Ophthalmic Res

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Aims: Our purpose was to detect the rate of initial manifestation of sarcoidosis in the eye. Material and Methods: We conducted a retrospective chart review in a sarcoidosis clinic in Germany. Ophthalmological data were obtained by using a standardized protocol, including the medical history, any comorbidity, onset and type of ocular manifestation that was evaluated by slit lamp, tonometry and fundoscopy. Results: In the cohort of 1,800 patients (mean age 38.1 ± 11.8 years), diagnosis of sarcoidosis was established most commonly by bilateral hilar lymphadenopathy (96.2%), histopathology (46.9%) or other organ manifestations. The initial clinical presentation of sarcoidosis (mean age 34.1 ± 10.8 years) had often been eye manifestation (21.2%). Within this group, anterior uveitis was most common (76.4%), followed by intermediate (17.3%) and posterior uveitis (4.7%). Conclusions: The eye is commonly the first site for manifestation of sarcoidosis. Ophthalmologists have a critical role in establishing the diagnosis of sarcoidosis.

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Section: Introductionmentioning

confidence: 99%

The Eye as a Common Site for the Early Clinical Manifestation of Sarcoidosis

Heiligenhaus

Wefelmeyer²,

Wefelmeyer³

et al. 2010

Ophthalmic Res

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“…Labial minor salivary gland biopsy (or lip biopsy) is used mainly in Sjogren's syndrome, being a major di agnostic criterion, and in sarcoidosis where it is also becoming a significant di agnostic tool, not so much because of its yield but mainly because of its simplicity and extremely low morbidity. Clinically, sarcoidosis and Sjogren's syndrome are usually quite different, and they can get confused only when sarcoidosis presents with xerostomia, xerophthalmia or sal ivary gland swelling [4,5,[9][10][11][12]15] as demonstrated in one of our patients (see 'Materials and Methods').…”

Section: Discussionmentioning

confidence: 99%

“…There are occasions, however, when sar coidosis presents with swelling of salivary glands and even xerostomia and xero phthalmia, symptoms and signs character istic for Sjogren's syndrome [9][10][11][12]. This clinical confusion has created the impres sion that there may be also histologic over lap.…”

Section: Introductionmentioning

confidence: 97%

Labial Minor Salivary Gland Biopsy: a Highly Discriminatory Diagnostic Method between Sarcoidosis and Sjögren’s Syndrome

Giotaki¹,

Constantopoulos²,

Papadimitriou³

et al. 1986

Respiration

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Sixty labial minor salivary gland biopsies (lip biopsies) from 32 patients with sarcoidosis and 28 patients with primary Sjögren’s syndrome were evaluated retrospectively and blindly. Six biopsies revealed typical sarcoid granulomata. All six belonged to patients with previously diagnosed sarcoidosis. Twelve lip biopsies, all from sarcoidosis patients, were classified as presenting 1 + or less lymphoid infiltrates according to Tarpley’s classification. The biopsies of the remaining 14 patients with sarcoidosis showed normal tissues. Finally, 28 biopsies were classified as having 2+ or 3+ lymphoid infiltrates and/or fibrosis. All belonged to patients with Sjögren’s syndrome. Our results indicate that lip biopsy has a rather low diagnostic yield in sarcoidosis (19%) but, more importantly, it can discriminate very well between sarcoidosis and Sjögren’s syndrome

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“…Metastatic calcification is de fined as calcium deposition in extraskelctal tissues with abnormal calcium and phosphate Received: D ecem ber 16.1991 Accepted: D ecem ber 23,1991 metabolism. Hyperparathyroidism [3][4][5][6][7], pseudo-hypoparathyroidism [8], vitamin D intoxication [9], sarcoidosis [10] and chronic renal failure [11] can cause this condition. These kinds of calcification usually occur in the basement membrane of blood vessels and epithelial cells, and it is postulated that in tracellular calcium deposition in normal cells may be an effect of parathyroid hormone or vitamin D [1].…”

Section: Introductionmentioning

confidence: 99%

Bilateral Metastatic Sclerochoroidal Calcification in a Patient with Hyperparathyroidism

et al. 1992

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We present the case of a 39-year-old man with bilateral sclerochoroidal calcification with primary hyperparathyroidism. Both the calcium and parathyroid hormone levels were elevated. Funduscopic examination revealed slightly elevated, multiple yellow lesions in both eyes. Fluorescein angiography showed filling defects of the choroid. Ultrasonography showed elevated, highly reflective lesions, and a computed tomography scan of the globe disclosed sclerochoroidal lesions with high density. We discuss the mechanism of sclerochoroidal calcification.

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The Eyes in Sarcoidosis

Cited by 173 publications

References 18 publications

The Eye as a Common Site for the Early Clinical Manifestation of Sarcoidosis

The Eye as a Common Site for the Early Clinical Manifestation of Sarcoidosis

Labial Minor Salivary Gland Biopsy: a Highly Discriminatory Diagnostic Method between Sarcoidosis and Sjögren’s Syndrome

Bilateral Metastatic Sclerochoroidal Calcification in a Patient with Hyperparathyroidism

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