The Eye in Adrenal Sympathicoblastoma (Neuroblastoma)

Bothman, Louis; Blankstein, Samuel S.

doi:10.1001/archopht.1942.00880040122012

Cited by 19 publications

(6 citation statements)

References 19 publications

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“…In the analyzed case reports, ecchymosis occurred mainly in children with the primary tumor in the adrenal medulla. 18,24,29,32,33,37,55,75 According to Harreld et al, 5 the periorbital ecchymosis was not found to be associated with any specific tumor location, and its cause remains unknown. They reported that the age of patients with this symptom (2.39 y) was lower than in the entire group.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of the primary tumor localization in patients diagnosed with neuroblastoma, ganglioneuroblastoma, and ganglioneuroma according to the 84 analyzed case reports 9,10,12–14,16–18,21–31,33–39,44–53,55–62,64–66,68–79,81–84. AM indicates adrenal medulla; GN, ganglioneuroma; GNBL, ganglioneuroblastoma; NBL, neuroblastoma.…”

Section: Case Reports Analysismentioning

confidence: 99%

“…The incidence of opsoclonus-myoclonus syndrome and the associated symptoms in 68 children diagnosed with neuroblastoma, and 16 patients with ganglioneuroblastoma. Overall, there were 29 cases of opsoclonus-myoclonus syndrome 9,10,12–14,16–18,21–39,44–80. OMS indicates opsoclonus-myoclonus syndrome.…”

Section: Case Reports Analysismentioning

confidence: 99%

“…The following ophthalmologic symptoms were reported in the medical literature: Horner syndrome (HS),7–12 heterochromia,9 anisocoria,13–15 tonic pupil,13 dilated pupils,13,16 relative afferent pupillary defect,17 ptosis,7,18–20 opsoclonus-myoclonus syndrome (OMS),7,8,20–23 nystagmus,15 strabismus,8,19 cranial nerve palsy,7,24 paralysis of the extraocular muscles,18,25,26 visual field loss,7 blindness,14,15 decreased visual acuity,25 proptosis (referred to as exophthalmos),7,8,18–20 periorbital ecchymosis (also known as “raccoon eyes”),7,8,18,20 palpable periorbital mass,20,25,27 eyelids edema,18,28 keratitis,7,29 chemosis,28,29 subconjunctival hemorrhage,30–33 hyphema,26,34 scleral26 or corneal nodules,31 nodular iris lesions,35,36 papilledema,16,18 optic neuropathy,7,37 choroidal metastases 30,38,39. It is worth bearing in mind that an interruption in the oculosympathetic tract may lead to HS, which manifests as unilateral ptosis, miosis, and anhidrosis 40.…”

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confidence: 99%

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Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review

Kuchalska

Derwich²,

Gotz‐Więckowska

2022

Journal of Pediatric Hematology/Oncology

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Neuroblastoma (NBL) is the most common extracranial solid tumor found in pediatric patients. It develops from the sympathetic tract tissue. Although the symptoms are associated with tumor localization, sometimes NBL is manifested as ophthalmologic disorders. In this paper, we describe their incidence and the correlation with the prognosis. We searched 2 databases (PubMed and Web of Science) for papers published before April 2022, and concerned pediatric patients with NBL, which caused ophthalmologic changes. We collected 7 papers assessing the occurrence of ophthalmologic findings in the NBL patients, as well as 68 case reports presenting children with orbital changes and NBL, or with other tumors stemming from the sympathetic ganglia. The statistical analysis was performed to synthetize the data. The ophthalmologic signs occurred in 17.89% of the NBL cases; however, they were observed on presentation in 10.68%. The isolated ocular presentation was found in 2.56% of patients, whereas Horner syndrome was most frequent. The ophthalmologic symptoms correlated with patients’ age, primary tumor site, and survival rate. NBL may be challenging to diagnose in cases with isolated ophthalmologic manifestations. Numerous possible ocular signs can be observed, which emphasize the need for multidisciplinary care with regard to the NBL patients.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reports Analysismentioning

confidence: 99%

Section: Case Reports Analysismentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review

Kuchalska

Derwich²,

Gotz‐Więckowska

2022

Journal of Pediatric Hematology/Oncology

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“…In two of his cases ecchymosis of the eyelids was the first physical sign. Bothman and Blankstein (1942), discussing the importance of ocular findings in neuroblastoma, reported four cases observed by them in 1936-37. 1n one of these, ecchymosis of an eyelid was the presenting sign.…”

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confidence: 99%