The extraction and fractionation of specialty lipids using near critical fluids

Catchpole, Owen J.; Tallon, Stephen; Eltringham, Wayne; Grey, John B.; Fenton, Kristina; Vági, Erika; Vyssotski, Mikhail; MacKenzie, Alan; Ryan, Jason; Yin, Zhu

doi:10.1016/j.supflu.2008.10.008

Cited by 76 publications

(44 citation statements)

References 36 publications

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“…Different solvents other than CO2 are under study in integrated processes of biocatalysis+extraction; in this sense, dimethyl ether seems to be a promising solvent mainly for hydrophobic compounds. Some of its uses have been recently reviewed by Catchpole et al [72].…”

Section: Applicationsmentioning

confidence: 99%

Compressed fluids for the extraction of bioactive compounds

Herrero

Castro-Puyana

Mendiola

et al. 2013

TrAC Trends in Analytical Chemistry

289

146

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ABSTRACT.The improvement of sample preparation and extraction techniques for natural bioactive compounds determinations is of great importance nowadays. New concepts are being introduced in this field, not only related to enhancement of extraction efficiencies but also related to environmental impact. This evolution towards Green Chemistry is pushing to new extraction and sample preparation processes that should be faster, more reproducible and more environmentally friendly. In this context, compressed fluidsbased sample preparation techniques (such as supercritical fluid extraction and pressurized liquid extraction) are demonstrating good capabilities. In this review, an updated knowledge on the techniques will be presented together with the main technical developments and the most notable recent applications for the extraction of bioactive compounds.Keywords: bioactive compounds, natural samples, plants, agricultural by-products, pressurized liquid extraction, supercritical fluid extraction, subcritical water extraction Abbreviations: ASE, accelerated solvent extraction; DHA, docosahexaenoic acid; EAE, enzyme-assisted extraction; EPA, eicosapentaenoic acid; IL, ionic liquids; MIP, molecular imprinted polymers; PFE, pressurized fluid extraction; PHSE, pressurized hot solvent extraction; PHWE, pressurized hot water extraction; PLE, pressurized liquid extraction; PLPW, pressurized low polarity water extraction; n-3 PUFA, n-3 polyunsaturated fatty acid; RAM, restricted access media; scCO2, supercritical CO2; SFE, supercritical fluid extraction; SHWE, superheated water extraction; SPE, solid Published in TrAC. Trends in analytical chemistry [0165-99362012 vol:43 pg:67 -83 http://dx.doi.org/10.1016/j.trac.2012.12.008 3 phase extraction; SWE, subcritical water extraction; TG, triglycerides; UAE, ultrasound assisted extraction; WEPO, water extraction and particle formation on-line.

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Section: Applicationsmentioning

confidence: 99%

Compressed fluids for the extraction of bioactive compounds

Herrero

Castro-Puyana

Mendiola

et al. 2013

TrAC Trends in Analytical Chemistry

289

146

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“…Oils to be used for PUFA concentration by SFE require preparation steps of extraction, hydrolysis, and esterification by conventional methods [36,37]. Some of the processes used as pre-concentration step previous to the supercritical CO 2 extraction process are urea fractionation, enzymatic fractionation, or industrial fermentation of micro-organisms [38]. The hydrolysis of blackcurrant oil TAGs to produce FFAs with low content in GLA and partial glycerols enriched in GLA has been reported using supercritical CO 2 [27].…”

Section: Supercritical Fluid Extractionmentioning

confidence: 99%

Gamma‐linolenic and stearidonic acids: Purification and upgrading of C18‐PUFA oils

Guil‐Guerrero

Rincón‐Cervera

Venegas‐Venegas

2010

Euro J Lipid Sci & Tech

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“…The high cost of organic solvents, the increasing restrictions due to safety and environmental concerns as well as the requirements of nutraceuticals market asking for natural products, have extended the demand for new extraction methods that overcome these handicaps. In this way, supercritical fluid extraction (SFE), using carbon dioxide, is a promising alternative [12][13][14][15][16][17][18][19], because it is nontoxic, nonexplosive, it can be easily removed from the extracts, and the selectivity of the extraction can be modified by changes in pressure and temperature.…”

Section: Introductionmentioning

confidence: 99%

Supercritical fluid extraction of lipids from broccoli leaves

Arnáiz

Bernal

Martín

et al. 2011

Euro J Lipid Sci & Tech

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The supercritical fluid extraction (SFE) and fractionation of lipids from broccoli leaves is presented in this work. For this purpose the effect of the different variables on the extraction was studied, obtaining the best results at 608C, 300 bar and 3 mL/min. Two different fractions were obtained: First, the samples were extracted with pure CO 2 , and afterward the residual material was extracted using CO 2 modified with 15% of methanol. The total fatty acid content of the extracts was determined by GC-MS and compared with those results obtained by Soxhlet extraction with hexane and a chloroform/methanol (2:1) mixture. The SFE extracts presented a higher percentage of unsaturated fatty acids, especially the polyunsaturated 18:3 n À 3. The methodology was successfully applied to the analysis of the fatty acid composition of the leaves from five different cultivars of broccoli. In all the samples the main fatty acids were a-linolenic (18:3 n À 3), linoleic (18:2 n À 6), and palmitic (16:0). Among the different cultivars analyzed, Naxos variety presented the highest levels in fatty acids, while Parthenon and Viola the lowest. Practical applications:The proposed method allows the fractionation of lipids from broccoli leaves using a small volume of organic solvent and mild conditions. This is advantageous compared to conventional methods where large volumes or organic solvents are used, and the cost and time for the removal of these solvents, along with the possibility of degradation and toxicity, are the major disadvantages. The results obtained contribute to a better compositional characterization and a possible revaluation of this by-product as a source of biologically active compounds.

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The extraction and fractionation of specialty lipids using near critical fluids

Cited by 76 publications

References 36 publications

Compressed fluids for the extraction of bioactive compounds

Compressed fluids for the extraction of bioactive compounds

Gamma‐linolenic and stearidonic acids: Purification and upgrading of C18‐PUFA oils

Supercritical fluid extraction of lipids from broccoli leaves

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