The Extraction and Development of Antitumor-Active Polysaccharides from Medicinal Mushrooms in Japan (Review)

Mizuno, Takashi

doi:10.1615/intjmedmushrooms.v1.i1.20

Cited by 242 publications

(152 citation statements)

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“…Uncontrolled reactions of production of oxygen reactive species lead to many pathophysiological disorders [3]. Many oxidative stresses, which lead to brain dysfunction, pathology of cancer, atherosclerosis, malaria and rheumatoid arthritis are also associated with cell damage caused by excess free radicals.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera Cantharellus and Afrocantharellus from Tanzania

Tibuhwa¹

2014

FNS

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Cantharellus and Afrocantharellus mushrooms are widely consumed in both fresh and dry forms. However, their antioxidant and whether their values changing with drying processes are not known. This study establishes their values and the effect of sun drying on their quality and quantity. Methanolic extracts of five Cantharellus and two Afrocantharellus species were investigated. The investigation used (1,1-diphenyl-2-picrylhydrazyl radical) DPPH as a substrate to determine radical scavenging abilities. Further quantitative analyses for carotenoids, flavonoid, total phenolic compounds and vitamin C content were done using spectrophotometric assay at 515 nm. Comparatively, fresh mushroom had higher vitamin C and Lycopene contents than their dry counterparts with β-carotene. Flavonoid and phenolic compounds were higher in dry forms than those in their fresh counterparts. Radical scavenging ability also varied with fresh forms depicting higher activity compared to dry forms. The variation was low in Afrocantharellus species (0.8% and 0.99%) while it was higher in Cantharellus species (24.12% and 7.52%). The highest ability was observed in fresh forms of Cantharellus pseudocibarius (EC 50 < 0.14 mg/ml) while the least ability (EC 50 = 0.4 mg/ml) was from dry form of Cantharellus rufopunctatus. This shows that studied mushrooms are rich in antioxidants and their quality and quantities are affected differently in both forms. Both dry and fresh mushrooms are potential sources of natural antioxidants. The portrayed high scavenging ability by these mushrooms envisages promoting them into potential nutraceutics.

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Section: Introductionmentioning

confidence: 99%

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera Cantharellus and Afrocantharellus from Tanzania

Tibuhwa¹

2014

FNS

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“…Health promoting properties such as antioxidant, antimicrobial, anticancer, cholesterol lowering and immunostimulatory effects, have been reported for some species of mushrooms (5,19,20). Both fruiting body and the mycelium contain compounds with wide-ranging antioxidant and antimicrobial activities (5,11).…”

Section: Introductionmentioning

confidence: 99%

Free radical scavenging and antimicrobial properties of extracts of wild mushrooms

Oyetayo¹

2009

Braz. J. Microbiol.

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Antioxidant and antimicrobial potentials of extracts obtained from four wild mushrooms, Termitomyces clypeatus (TCE), Termitomyces robustus (TRE), Lentinus subnudus (LSE) and Lenzites species (LZE) collected in Nigeria were investigated. LSE and LZE displayed good scavenging activity against 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH) and ferrous ion radicals at concentration of 2 mg/mL. However, TRE and TCE exhibited better superoxide anion scavenging effect at 2 mg/mL. All extracts (TCE, TRE, LSE and LZE) had comparable scavenging effect on hydroxyl radicals as butylated Hydroxytoluene (BHT) used as control. Moreover, extracts from the wild mushrooms were able to inhibit the growth of all indicator organisms at concentrations between 12.5 mg/mL to 100 mg/mL. LSE and LZE, however, showed better antimicrobial effect on the indicator organisms. The results suggest that extracts obtained from the four wild mushrooms may serve as sources of new bioactive compounds with effective antioxidant and antimicrobial activity.

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“…A number of methods have been developed to extract anti-cancer polysaccharides from mushroom fruitbodies, mycelium and liquid media (Mizuno, 1999). In this study, extraction condition of total polysaccharides for effective yield enzyme amount, extraction temperature, extraction time and extraction pH is investigated.…”

Section: Discussionmentioning

confidence: 99%

Optimization of enzyme assisted extraction of polysaccharides from Poria cocos

Khaskheli¹,

Khaskheli²,

Liu³

et al. 2017

J. Med. Plants Res.

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Water-soluble polysaccharide was isolated from Poria cocus by enzyme-assisted method using orthogonal methodology. By single factor test and orthogonal group, the extraction conditions of watersoluble polysaccharide were investigated, such as liquid-solid ratio, temperature, time and pH. The optimum conditions for single factor were as follows Enzyme concentration (%), Extraction temperature oC, Extraction time/h, Extraction pH. The result revealed that 2% complex enzyme, remained most important factor of polysaccharide extraction, followed by temperature and pH. The liquid-solid ratio was 1:50, temperature was 40°C, time was 3.0 h, and pH was 5. The highest extraction rate of crude polysaccharide remained 4.14%. Results indicated that the complex-enzyme assisted remained best technique for extracting polysaccharide from P. cocus. It proved to be as highly effective as well as energy and time saving extraction techniques.

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The Extraction and Development of Antitumor-Active Polysaccharides from Medicinal Mushrooms in Japan (Review)

Cited by 242 publications

References 0 publications

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera <i>Cantharellus</i> and <i>Afrocantharellus</i> from Tanzania

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera <i>Cantharellus</i> and <i>Afrocantharellus</i> from Tanzania

Free radical scavenging and antimicrobial properties of extracts of wild mushrooms

Optimization of enzyme assisted extraction of polysaccharides from Poria cocos

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The Extraction and Development of Antitumor-Active Polysaccharides from Medicinal Mushrooms in Japan (Review)

Cited by 242 publications

References 0 publications

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera &lt;i&gt;Cantharellus&lt;/i&gt; and &lt;i&gt;Afrocantharellus&lt;/i&gt; from Tanzania

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera &lt;i&gt;Cantharellus&lt;/i&gt; and &lt;i&gt;Afrocantharellus&lt;/i&gt; from Tanzania

Free radical scavenging and antimicrobial properties of extracts of wild mushrooms

Optimization of enzyme assisted extraction of polysaccharides from Poria cocos

Contact Info

Product

Resources

About

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera <i>Cantharellus</i> and <i>Afrocantharellus</i> from Tanzania

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera <i>Cantharellus</i> and <i>Afrocantharellus</i> from Tanzania