The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells

Deng, Yuanle; Li, Yali; Yang, Fangfang; Zeng, Anqi; Yang, Shuping; Luo, Yi; Zhang, Yiwen; Xie, Yongmei; Ye, Tinghong; Xia, Yong; Yin, Wenya

doi:10.1016/j.biopha.2017.07.008

Cited by 85 publications

(59 citation statements)

References 31 publications

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“…whole fruit extract ↓H 2 O 2 -induced oxidative stress; ↓apoptosis; natural antioxidants for skin health [37] whole fruit extract antimicrobial activity against 29 clinical Clostridium difficile isolates [38] juice extract inhibition of a-glucosidase activity [39] extract and juice prebiotic effect [40] juice ↓lipogenesis and lipolysis [41] juice inhibition of lipase, α-glucosidase and dipeptidyl peptidase-4 [42] peel extract inhibition of renal cell carcinoma growth [43] peel extract anti-neurodegenerative [44] peel extract ↑apoptosis and ↓metastasis in prostate cancer cells [45] peel and juice extract inhibition of cariogenic bacteria [46,47] peel and fruit extract stimulates osteoblastic differentiation (osteoporosis) [48,49] peel polysaccharide immunostimulatory effect [50] punicalagin antiproliferative activity against human lung, breast, cervical and prostate cancer cells [51][52][53] punicalagin ↑papillary thyroid human carcinoma cell death [54] punicalagin inhibition of lipopolysaccharide-induced memory impairment (Alzheimer's disease) [55] punicalagin attenuates osteoclast differentiation (osteoporosis) [56] pomegranate-derived products (juice, extract, oil) photo-chemopreventive effect in human reconstituted skin [57] urolithins inhibition of neuroinflammation (Alzheimer's disease) [58] 3.1.…”

Section: Derivative Effect Referencesmentioning

confidence: 99%

“…Therefore, pomegranate extracts may be used as dietary adjuncts to manage patients with small, localized, incidentally identified renal tumors, and this may lead to the avoidance of nephrectomy [43]. Pomegranate peel extracts and punicalagin, a polyphenol from pomegranate fruit, have shown growth inhibition on prostate cancer cells and anti-proliferative activity via the induction of apoptosis [45,51]. Additionally, in vitro studies have revealed that punicalagin induces the cell death of papillary thyroid carcinoma cells [54], inhibits cell proliferation in a non-small lung carcinoma cell line [52], and exerts a strong anti-proliferative activity against the human lung, breast, and cervical cancer cell lines [53].…”

Section: Anticarcinogenic Effectmentioning

confidence: 99%

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Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Kandylis

Kokkinomagoulos

2020

Foods

161

109

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Pomegranate (Punica granatum L.) is an ancient fruit that is particularly cultivated in west Asia, though it is also cultivated in the Mediterranean region and other parts of the world. Since ancient years, its consumption has been associated with numerous health benefits. In recent years, several in vitro and in vivo studies have revealed its beneficial physiological activities, especially its antioxidative, antimicrobial and anti-inflammatory properties. Furthermore, human-based studies have shown promising results and have indicated pomegranate potential as a protective agent of several diseases. Following that trend and the food industry’s demand for antioxidants and antimicrobials from natural sources, the application of pomegranate and its extracts (mainly as antioxidants and antimicrobials), has been studied extensively in different types of food products with satisfactory results. This review aims to present all the recent studies and trends in the applications of pomegranate in the food industry and how these trends have affected product’s physicochemical characteristics and shelf-life. In addition, recent in vitro and in vivo studies are presented in order to reveal pomegranate’s potential in the treatment of several diseases.

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Section: Derivative Effect Referencesmentioning

confidence: 99%

Section: Anticarcinogenic Effectmentioning

confidence: 99%

Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Kandylis

Kokkinomagoulos

2020

Foods

161

109

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“…Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells. Prostate cancer is a big threat to males due to its poor prognosis and high mortality rate (Deng et al, 2017). In contrast to pomegranate or its peel, pomegranate flower is less used in health studies.…”

Section: Activities the Extract Frommentioning

confidence: 99%

Evaluation and comparison of staining effect of Punica granatum flower extract on testis and ovary of Wistar rats: First results

Kuşçulu¹

2018

Afr. J. Biotechnol.

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The evaluation and comparison of the staining effect of pomegranate (Punica granatum) flower extract (dye solution) on histological sections of rat testis and ovary provides a simple, quick technique for the visualisation of both cells. In the developed procedure, this work shows the staining effect of P. granatum flower extract used at different pH of dye bath and temperatures on the histological sections of rat testis and ovary. A 20% stock solution of P. granatum flower extract was prepared by dissolving 20 g of the dye in 100 mL ethanol at room temperature for several hours. After 24 h, the deep-red coloured solution was filtered (0.45 µm filter) to remove any undissolved dye. This stock solution was stored at room temperature and each day a 5 mL sample was taken and adjusted to different pH with dilute ammonia (NH 3 ) using pH meter. Best staining effects conditions were obtained by testing the different pH of dye (1-2, 4-5) and temperature. The testis and ovary are stained in different colors; lamina propria section and spermatogonia cells of testis were more purple than the same sections of ovary at room temperature and pH of 1-2 dye bath. Therefore, the developed method has been applied successfully for the visualization of rat testis and not the ovarian tissue.

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“…In vitro studies have already described the positive results of treatment with P. granatum extract, with apoptosis in many cell lines, such as colon cells-SW620, HT-29, and HCT-116 (Joseph et al, 2013), prostate cells-DU145, PC3, mouse prostate cancer cell TRAMP-C1 (Deng et al, 2017;Deng et al, 2018), lung cells-A549, H1299 (Li et al, 2016), and breast cells-MCF-7 (Shirode et al, 2014;Chen et al, 2015). However, in these models, the systemic effect of these compounds could not be assessed.…”

Section: Introductionmentioning

confidence: 99%

In vivo antitumor effect of the aqueous extract of Punica granatum in the sarcoma 180 murine model

Bastos¹,

Costa²,

Valois³

et al. 2018

J. Med. Plants Res.

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Punica granatum, specifically the fruit, has a long ethno medical history and is a phytochemical reservoir of great medicinal value. The phytochemistry and pharmacological actions of all P. granatum components suggest a wide range of clinical applications. The aim of the present study is to investigate the anticancer potential of aqueous extract of P. granatum (AEPG) in experimental models. The chemical composition of the AEPG was assessed by HPLC-DAD. In vivo antitumor activity was assessed in sarcoma 180 bearing mice. To evaluate the toxicological aspects related to the AEPG treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were performed. Gallic acid, punicalagin α, punicalagin β, and ellagic acid were identified as the major phytochemical compounds of the extract. AEPG and 5-fluorouracil (5-FU) induced significant inhibition of tumor growth when compared with saline (p < 0.05). The percentage of apoptotic cells was significantly increased in 5-FU (p < 0.01) and AEPG treated groups (p < 0.01). No significant difference was observed between 5-FU and the three doses of AEPG. 5-FU induced toxic effects, such as decrease of body weight, splenic atrophy, and leukopenia, but these effects were not found in AEPG treated groups. The results provide evidence that AEPG exhibits comparable antitumor effects as 5-FU in a murine model, likely the result of increased apoptotic rate, but with no remarkable side effects presented by 5-FU.

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The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells

Cited by 85 publications

References 31 publications

Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Evaluation and comparison of staining effect of Punica granatum flower extract on testis and ovary of Wistar rats: First results

In vivo antitumor effect of the aqueous extract of Punica granatum in the sarcoma 180 murine model

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