The (Extracellular) Matrix Reloaded: Imaging Matrix Metalloproteinase Activity

Lillis, Kyle P.

doi:10.1177/1535759720988547

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…While cellular changes during the latent period have been widely explored, limited attention has been given to the extracellular space. Extracellular matrix (ECM) forms the extracellular structural base, and the reorganization of ECM has been linked to the development of epilepsy (129). The spatial revolution of ECM guides neurogenesis, migration, and axon growth during brain development.…”

Section: Extracellular Matrixmentioning

confidence: 99%

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

et al. 2022

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Temporal lobe epilepsy (TLE) is one of the most common and severe types of epilepsy, characterized by intractable, recurrent, and pharmacoresistant seizures. Histopathology of TLE is mostly investigated through observing hippocampal sclerosis (HS) in adults, which provides a robust means to analyze the related histopathological lesions. However, most pathological processes underlying the formation of these lesions remain elusive, as they are difficult to detect and observe. In recent years, significant efforts have been put in elucidating the pathophysiological pathways contributing to TLE epileptogenesis. In this review, we aimed to address the new and unrecognized neuropathological discoveries within the last 5 years, focusing on gene expression (miRNA and DNA methylation), neuronal peptides (neuropeptide Y), cellular metabolism (mitochondria and ion transport), cellular structure (microtubule and extracellular matrix), and tissue-level abnormalities (enlarged amygdala). Herein, we describe a range of biochemical mechanisms and their implication for epileptogenesis. Furthermore, we discuss their potential role as a target for TLE prevention and treatment. This review article summarizes the latest neuropathological discoveries at the molecular, cellular, and tissue levels involving both animal and patient studies, aiming to explore epileptogenesis and highlight new potential targets in the diagnosis and treatment of TLE.

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Section: Extracellular Matrixmentioning

confidence: 99%

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

et al. 2022

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“…The ECM constitutes a three-dimensional, cell-free matrix surrounding neurons and glial cells in the CNS, which synthesize and secrete ECM molecules ( Dityatev, 2010 ; Lau et al, 2013 ; Lillis, 2021 ). The ECM is rich in proteoglycans and hydrophilic glycosaminoglycans and also contains collagen, elastin, fibronectin, laminin, and other glycoproteins and accounts for around 20% of cerebral volume ( Cragg, 1979 ; Lau et al, 2013 ; Theocharis et al, 2016 ).…”

Section: Extracellular Matrix and The Extracellular Matrix Molecule R...mentioning

confidence: 99%

Considering the Role of Extracellular Matrix Molecules, in Particular Reelin, in Granule Cell Dispersion Related to Temporal Lobe Epilepsy

Leifeld

Förster

Reiss

et al. 2022

Front. Cell Dev. Biol.

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The extracellular matrix (ECM) of the nervous system can be considered as a dynamically adaptable compartment between neuronal cells, in particular neurons and glial cells, that participates in physiological functions of the nervous system. It is mainly composed of carbohydrates and proteins that are secreted by the different kinds of cell types found in the nervous system, in particular neurons and glial cells, but also other cell types, such as pericytes of capillaries, ependymocytes and meningeal cells. ECM molecules participate in developmental processes, synaptic plasticity, neurodegeneration and regenerative processes. As an example, the ECM of the hippocampal formation is involved in degenerative and adaptive processes related to epilepsy. The role of various components of the ECM has been explored extensively. In particular, the ECM protein reelin, well known for orchestrating the formation of neuronal layer formation in the cerebral cortex, is also considered as a player involved in the occurrence of postnatal granule cell dispersion (GCD), a morphologically peculiar feature frequently observed in hippocampal tissue from epileptic patients. Possible causes and consequences of GCD have been studied in various in vivo and in vitro models. The present review discusses different interpretations of GCD and different views on the role of ECM protein reelin in the formation of this morphological peculiarity.

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“…11 Therefore, a sensitive and accurate detection of MMPs is necessary for clinical diagnosis, prognosis and MMP inhibitor screening. 12 Various methods have been reported for the detection of MMPs, including immunoblotting, 13 enzyme-linked immunosorbent assay (ELISA), 14 colorimetric assay, 15,16 fluorescence method, 17,18 zymography, 19 electroanalytical immunoassay, 20,21 surface-enhanced Raman scattering (SERS) 22,23 and surface plasma resonance (SPR) base methods. 24,25 Among them, fluorescence methods are promising due to their high sensitivity and simplicity of operation.…”

Section: Introductionmentioning

confidence: 99%

Polypeptide induced perylene probe excimer formation and its application in the noncovalent ratiometric detection of matrix metalloproteinase activity

et al. 2022

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The (Extracellular) Matrix Reloaded: Imaging Matrix Metalloproteinase Activity

Abstract: [Box: see text]

Cited by 3 publications

References 8 publications

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

Considering the Role of Extracellular Matrix Molecules, in Particular Reelin, in Granule Cell Dispersion Related to Temporal Lobe Epilepsy

Polypeptide induced perylene probe excimer formation and its application in the noncovalent ratiometric detection of matrix metalloproteinase activity

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