The extracellular matrix of the human fetal membranes: Structure and function

Bryant‐Greenwood, Gillian D.

doi:10.1016/s0143-4004(98)90092-3

Cited by 223 publications

(148 citation statements)

References 78 publications

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“…Soon after the extraembryonic mesoderm becomes closely associated with the amniotic ectoderm, the human amnion matures; this is characterized by accumulation of ECM proteins (Bryant-Greenwood, 1998). Besides conferring protection to the embryo, and containing the amniotic fluid, the amnion also regulates the composition and volume of amniotic fluid.…”

Section: Amnion Development In Humansmentioning

confidence: 99%

On the origin of amniotic stem cells: of mice and men

Dobreva¹,

Pereira²,

Deprest³

et al. 2010

Int. J. Dev. Biol.

135

139

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A common characteristic of mammals is the development of extraembryonic supporting tissues and organs that are required for embryonic implantation, survival and development in utero. The amnion is the innermost extraembryonic membrane that eventually surrounds the fetus of amniotes, and contains the amniotic fluid. Next to its function in in utero development, the amnion has been shown to have an important potential for clinical applications. It is mainly used as a dressing to stimulate healing in skin and ocular wounds. Moreover, cells derived from the amniotic membrane and amniotic fluid have been reported to possess stem cell features, like pluripotent differentiation ability. Little is known about the early development of this membrane in humans. The mouse is a powerful genetic model organism that can be used to address the dynamics and the developmental origin of amnion and amnion-derived stem cells. Here, we discuss some fundamental differences in amnion development in the disc-shaped primate embryo and in the cup-shaped mouse embryo. We emphasize the consequences that this may have on the derivation of amniotic "stem" cells. After revision of the different isolation procedures of amniotic (fluid) derived "stem" cells from rodents, we reveal striking differences in the sources used to derive these cells across studies. The profound differences in the development of the extraembryonic membranes and cavities between primates and rodents may result in comparing cell types of different developmental origins, eventually leading to missinterpretations.

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Section: Amnion Development In Humansmentioning

confidence: 99%

On the origin of amniotic stem cells: of mice and men

Dobreva¹,

Pereira²,

Deprest³

et al. 2010

Int. J. Dev. Biol.

135

139

View full text Add to dashboard Cite

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“…[24][25][26][27][28][29][30][31] The MMP-9 attacks the collagen fibers in the fetal membranes, thereby dissociating the layers that make up the fetal membranes and thickening the spongy layer that separates the amnion from the chorion. 32 Altogether these structural changes lead to a significantly thinner and weaker region in the fetal membranes. There is also ample evidence demonstrating a role for infection or inflammation role in fetal membrane production of MMP-9.…”

Section: Discussionmentioning

confidence: 99%

Class I to III Histone Deacetylases Differentially Regulate Inflammation-Induced Matrix Metalloproteinase 9 Expression in Primary Amnion Cells

et al. 2014

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Matrix metalloproteinase (MMP) 9 plays an important role in the degradation of the extracellular matrix in fetal membranes, and pathological activation of MMP-9 can lead to preterm birth. In nongestational tissues, modulation of histone deacetylases (HDACs) regulates MMP-9 expression. The aim of this study was to determine whether class I to III HDACs regulate MMP-9 expression and activity in primary amnion cells. Class I and II HDAC regulation of MMP-9 was assessed using the general class I and II HDAC inhibitors (HDACi) trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA), the class I HDACi MS-275, and the class II HDACi MC1568. Class III HDAC regulation of MMP-9 was assessed using the SIRT1 activators resveratrol and SRT1720 as well as SIRT1 small interfering RNA (siRNA). Primary amnion epithelial cells were incubated with 1 ng/mL interleukin (IL) 1b in the absence or presence of 0.3 mmol/L TSA, 5 mmol/L SAHA, 2.5 mmol/L MS-275, 2.5 mmol/L MC1568, 50 mmol/L resveratrol, or 10 mmol/L SRT1720 for 20 hours. We found that the class I and II HDACi TSA and SAHA and the class II HDACi MC1568 significantly decreased IL-b-induced MMP-9 gene and pro-MMP-9 expression in primary amnion cells. There was, however, no effect of the class I HDACi MS-275 on IL-b-induced MMP-9 expression. On the other hand, inhibition of class III HDAC SIRT1 using siRNA significantly augmented IL-1b-induced MMP-9, and SIRT1 activation using resveratrol and SRT1720 inhibited IL-1b-induced MMP-9 expression. In summary, class I to III HDACs differentially regulate inflammation-induced MMP-9 expression in primary amnion cells.

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“…3 The mem bra ne's ten si le strength de pends on the col la gen that ma kes up the ex tra cel lu lar mat rix (ECM). 4,5 The strength of the fe tal mem bra nes is tho ught to be inf lu en ced by both synthe sis and deg ra da ti on of the com po nents of the ex tra cel lu lar mat rix. 6,7 The fib ril lar col la gens (type1, 3, and 5) are pre su med to be the cri ti cal com po nents len ding ten si le strength to the am ni on.…”

mentioning

confidence: 99%

Amniotic Membrane’s Hydroxyproline Content and Preterm Premature Rupture of Membranes

Saglam¹,

Derwig²,

Kasap³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S TTR RA AC CT T O Ob b j je ec c t ti i v ve e: : To de ter mi ne whet her pre term pre ma tu re rup tu re of the mem bra nes (PPROM) is ca u sed by a ge ne ra li sed and/or lo ca li sed re duc ti on in the hydroxy pro li ne con tent of the am ni o tic mem bra ne. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : This study inc lu ded 105 par tu ri ent wo men who de li vered bet we en Sep tem ber 2005-March 2006 in Ze ka i Ta hir Bu rak Wo men's He alth Edu ca ti on and Rese arch Hos pi tal High Risk Preg nancy De part ment. The first gro up inc lu ded 40 par tu ri ent wo men with PPROM. The se cond gro up inc lu ded 65 par tu ri ent wo men with in tact mem bra nes ha ving an elec tive Ca e sa re an sec ti on with the di ag no sis of pre vi o us ca e sa re an sec ti on. In the PPROM gro up (n= 40), 25 wo men de li ve red va gi nally and 15 wo men had an emer gency Ca e sa re an sec ti on for fe tal dis tress at the be gin ning of la bo ur. The hydroxy pro li ne con tent of the amniotic membranes of 40 wo men with pre term pre ma tu re rup tu re of the mem bra nes was com pa red with these of 65 wo men who deli ve red by elec ti ve Ca e sa re an sec ti on. Thre e re gi ons of the am ni o tic mem bra ne we re exa mi ned: 1) the rup tu re si te 2) the mid zo ne are a, which was the half way bet we en the rup tu re site and pla cen tal ed ge; and 3) pe rip la cen tal are a, which was usu ally 10-12 cm away from the rup tu re si te. R Re e s su ul lt ts s: : In the rup tu re si te, no sig ni fi cant dif fe ren ce was de tec ted in the hydroxy pro li ne con tent bet we en the con trol gro up (0.17-0.63 mg/mg pro te in) and the PPROM gro up (0.26-0.51mg/mg pro te in) (p= 0.916). In the mid zo ne are a, the re was no sig ni fi cant dif fe ren ce bet we en the con trol gro up (0.16-1.45 mg/mg pro te in) and the PPROM gro up (0.24-0.84 mg/mg pro te in) (p= 0.462). In the pe rip la cen tal are a the re was no sig ni fi cant dif fe ren ce bet we en the con trol gro up (0.23-1.35 mg/mg pro te in) and the PPROM gro up (0.23-1.13 mg/mg pro te in) (p= 0.753). C Co on nc c l lu u s si i o on n: : Pre term pre ma tu re rup tu re of the mem branes do es not ap pe ar to be ac com pa ni ed by a ge ne ra li sed or lo ca li sed re duc ti on in the collagen of amni o tic mem bra ne. K Ke ey y W Wo or rd ds s: : Fe tal mem bra nes, pre ma tu re rup tu re; hydroxy pro li ne; am ni o tic mem bra ne Ö ÖZ ZE ET T A Am ma aç ç: : Pre term er ken mem bran rüp tü rü nün (PEMR) am ni on za rı nın hid rok sip ro lin içe ri ğin -de ki yay gın ve ya lo ka li ze azal ma sın dan kay nak la nıp kay nak lan ma dı ğı nı be lir le mek. G Ge e r re eç ç v ve e Y Yö ön n t te em m --l le er r: : Ça lış ma ya Ze ka i Ta hir Bu rak Ka dın Sağ lı ğı Eği tim ve Araş tır ma Has ta ne si Yük sek Risk li Ge be lik Bö lü mü'n de Ey lül 2005-Mart 2006 ara sın da do ğum ya pan 105 ka dın alın dı. İlk grup PEMR si olan 40 ka dı nı kap sı yor du. İkin ci grup ta da ha ön ce se zar yen ge çir me öy kü sü ol du ğu için elek tif se zar ye ne alı -...

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The extracellular matrix of the human fetal membranes: Structure and function

Cited by 223 publications

References 78 publications

On the origin of amniotic stem cells: of mice and men

On the origin of amniotic stem cells: of mice and men

Class I to III Histone Deacetylases Differentially Regulate Inflammation-Induced Matrix Metalloproteinase 9 Expression in Primary Amnion Cells

Amniotic Membrane’s Hydroxyproline Content and Preterm Premature Rupture of Membranes

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